Photoreceptor Cells

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  Subject Areas on Research

  • A halo visual illusion. 
  • A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge. 
  • A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs. 
  • A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. 
  • Actin-dependent myoid elongation in teleost rod inner/outer segments occurs in the absence of net actin polymerization. 
  • Adapting bump model for ventral photoreceptors of Limulus. 
  • Adapting-bump model for eccentric cells of Limulus. 
  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. 
  • An effector site that stimulates G-protein GTPase in photoreceptors. 
  • Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina. 
  • Apoptosis in human retinal degenerations. 
  • Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. 
  • CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. 
  • Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. 
  • Calmodulin in bovine rod outer segments. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. 
  • Dispersion of latencies in photoreceptors of Limulus and the adapting-bump model. 
  • Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat. 
  • Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. 
  • Freeze-fracture study of vesicle disruption and inversion in isolated bovine rod outer segment disks. 
  • G proteins. Visual differences. 
  • Generalized sampling using a compound-eye imaging system for multi-dimensional object acquisition. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • Immunolocalization of PKC zeta in rat photoreceptor inner segments. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Increase in intracellular free calcium concentration of Limulus photoreceptors caused by a metabolic inhibitor. 
  • Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium. 
  • Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Isolation, rapid freezing, and freeze-fracture methods for frog retinal photoreceptors. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • Lability of the prolonged depolarizing afterpotential in Balanus photoreceptors. 
  • Lamellar structure of bleached and unbleached rod photoreceptor membranes. 
  • Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. 
  • Microtubule nucleation and organization in teleost photoreceptors: microtubule recovery after elimination by cold. 
  • Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species. 
  • Modulation of disk margin structure during renewal of cone outer segments in the vertebrate retina. 
  • Morphological components associated with frog cone outer segment disc margins. 
  • N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits. 
  • Nature of light-induced conductance changes in ventral photoreceptors of Limulus. 
  • Neuroscience: Visual restoration with optogenetics. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • On the asymmetry of frog retinal rod outer segment disk membranes. 
  • On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. 
  • Panretinal photocoagulation and retinal oxygenation in normal and diabetic cats. 
  • Paracrystalline inclusions associated with the disk membranes of frog retinal rod outer segments. 
  • Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia. 
  • Patterns of interdisk connections within the lamellar domains of retinal rod outer segment disks: observations relevant to the axial propagation of incisures. 
  • Persistence of prolonged light-induced conductance change in arthropod photoreceptors on recovery from anoxia. 
  • Photoreceptor Discs: Built Like Ectosomes. 
  • Photoreceptor apoptosis in animal models. Implications for retinitis pigmentosa research. 
  • Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release. 
  • Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Photosensing fungi: phytochrome in the spotlight. 
  • Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. 
  • Phytochrome regulation and differential expression of gibberellin 3b-hydroxylase genes in germinating Arabidopsis seeds 
  • Polarized distribution of Mr 210,000 and 190,000 analogs of erythrocyte ankyrin along the plasma membrane of transporting epithelia, neurons and photoreceptors. 
  • Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium. 
  • Posttranslational modifications of tubulin in teleost photoreceptor cytoskeletons. 
  • Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. 
  • Protective effects of resveratrol in experimental retinal detachment. 
  • Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. 
  • RGS9 knockout causes a short delay in light responses of ON-bipolar cells. 
  • RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. 
  • Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose. 
  • Retinal pathology in the Kearns-Sayre syndrome. 
  • Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia. 
  • Retinitis pigmentosa: clinical management based on current concepts. 
  • Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. 
  • Shortening of the calycal process actin cytoskeleton is correlated with myoid elongation in teleost rods. 
  • Site-directed mutagenesis of the inhibitory subunit of retinal rod cyclic GMP phosphodiesterase. 
  • Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. 
  • Structural features of the terminal loop region of frog retinal rod outer segment disk membranes: I. Organization of lipid components. 
  • Structural features of the terminal loop region of frog retinal rod outer segment disk membranes: III. Implications of the terminal loop complex for disk morphogenesis, membrane fusion, and cell surface interactions. 
  • Structural interpretation of the birefringence gradient in retinal rod outer segments. 
  • Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity. 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses. 
  • The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium. 
  • The carbohydrates in frog retinal rod outer segments. 
  • The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The role of calcium ions in the suppression of the photoresponse during anoxia and application of metabolic inhibitors. 
  • Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments. 
  • Two-dimensional rhodopsin crystals from disk membranes of frog retinal rod outer segments. 
  • Urethan-induced retinopathy in pigmented rats. 
  • cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology