Picornaviridae

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  Subject Areas on Research

  • Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region. 
  • Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors. 
  • Determinants of poliovirus neurovirulence. 
  • Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. 
  • Picornavirus entry. 
  • Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. 
  • The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation. 
  • Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.