Pigment Epithelium of Eye

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  Subject Areas on Research

  • Activin expression by cultured human retinal pigment epithelial cells. 
  • Adenocarcinoma of the retinal pigment epithelium: a diagnostic and therapeutic challenge. 
  • Adenoma of the retinal pigment epithelium simulating a juxtapapillary choroidal neovascular membrane. 
  • Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cells. 
  • Age-related alterations in vitamin A metabolism in the rat retina. 
  • Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells. 
  • Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. 
  • Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Autofluorescence of choroidal melanoma in 51 cases. 
  • Barriers to productive transfection of trabecular meshwork cells. 
  • Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. 
  • Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE. 
  • Ca++-switch induction of RPE differentiation. 
  • Can chorio-retinal biopsy be justified? 
  • Caspase-8-mediated apoptosis in human RPE cells. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Characterization of a novel family of ciliary body glycoproteins. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Clinical and functional findings in choroideremia due to complete deletion of the CHM gene. 
  • Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration. 
  • Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16. 
  • Combined hamartoma of the retina and retinal pigment epithelium: optical coherence tomography. 
  • Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report No. 15. 
  • Congenital ectropion uvea and mechanisms of glaucoma in neurofibromatosis type 1: new insights. 
  • Congenital fibrovascular pupillary membranes: clinical and histopathologic findings. 
  • Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. 
  • Dietary vitamins A and E influence retinyl ester composition and content of the retinal pigment epithelium. 
  • Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. 
  • Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration. 
  • Drusen of the optic disc. A retrospective study in cadaver eyes. 
  • Dynamic Imaging of a Pigmented Free-Floating Vitreous Cyst. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. 
  • Effects of indocyanine green on the retina and retinal pigment epithelium in a porcine model of retinal hole. 
  • Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. 
  • Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. 
  • Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat. 
  • Experimental suprachoroidal plombage with a urethane based hydrophilic polymer. 
  • Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells. 
  • Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Extensive subretinal pigment epithelial deposit in two brothers suffering from dominant retinitis pigmentosa. A histopathological study. 
  • Extracellular matrix in aged human ciliary body: an immunoelectron microscope study. 
  • Exudative retinal detachment after photodynamic injury. 
  • Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. 
  • Geographic atrophy in age-related macular degeneration and TLR3. 
  • Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7. 
  • Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy. 
  • Human RPE expression of cell survival factors. 
  • Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1. 
  • Hyalocytes synthesize and secrete inhibitors of retinal pigment epithelial cell proliferation in vitro. 
  • Hydrogen peroxide induces microvilli on human retinal pigment epithelial cells in culture. 
  • Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium. 
  • Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil. 
  • Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. 
  • L-DOPA is an endogenous ligand for OA1. 
  • Lactose supports Muller cell protein expression patterns in the absence of the retinal pigment epithelium. 
  • Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. 
  • Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. 
  • Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. 
  • Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity. 
  • Modulation of macrophage colony stimulating factor in cultured human retinal pigment epithelial cells. 
  • Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor. 
  • Monensin enhances the cytotoxic effect of antitransferrin receptor immunotoxin on cultured RPE cells. 
  • Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells. 
  • Multifocal posterior uveitis: clinical and pathological findings. 
  • Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. 
  • Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. 
  • Ocular reticulum cell sarcoma. 
  • Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients. 
  • Optical coherence tomography following photodynamic therapy with verteporfin for subfoveal predominantly classic choroidal neovascularization. 
  • Optical coherence tomography of congenital simple hamartoma of the retinal pigment epithelium. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Ouabain-sensitive Na+-K+ ATPase pumps in cultured human retinal pigment epithelium. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. 
  • Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. 
  • Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia. 
  • Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. 
  • Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration. 
  • Permissive glycan support of photoreceptor outer segment assembly occurs via a non-metabolic mechanism. 
  • Photochemical initiation of thrombosis. Fluorescein angiographic, histologic, and ultrastructural alterations in the choroid, retinal pigment epithelium, and retina. 
  • Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography. 
  • Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. 
  • Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. 
  • Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. 
  • Pigmented paravenous retinochoroidal atrophy. Discordant expression in monozygotic twins. 
  • Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium. 
  • Primary adenocarcinoma of pigmented ciliary epithelium in a phthisical eye. 
  • Pseudomelanomas after conservative management of uveal melanoma. 
  • Quantitative assessment of growth stimulating activity of the vitreous during PVR. 
  • Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization. 
  • Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole. 
  • Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. 
  • Retinal pathology in the Kearns-Sayre syndrome. 
  • Retinal pigment epithelial cells of the posterior pole have fewer Na/K adenosine triphosphatase pumps than peripheral cells. 
  • Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature. 
  • Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. 
  • Retinitis pigmentosa: clinical management based on current concepts. 
  • Retinomotor movements in isolated teleost retinal cone inner-outer segment preparations (CIS-COS): effects of light, dark and dopamine. 
  • Spontaneous giant retinal pigment epithelial tear associated with panuveitis. 
  • Sub-retinal drusenoid deposits in human retina: organization and composition. 
  • Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells. 
  • Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Terminology of sub-RPE deposits: do we all speak the same language? 
  • The antiproliferative effect of a transferrin-toxin on human retinal pigment epithelial cells and rabbit fibroblasts. 
  • The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium. 
  • The effectiveness of latanoprost for the treatment of pediatric glaucoma. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • The importance of Bcl-xL in the survival of human RPE cells. 
  • The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation. 
  • The surface oxidation potential of melanosomes measured by free electron laser-photoelectron emission microscopy. 
  • Topography of geographic atrophy in age-related macular degeneration. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula. 
  • Understanding RPE Lipofuscin. 
  • [Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells]. 
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  Keywords of People

  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Pharmacology & Cancer Biology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering