Pigment Epithelium of Eye
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Subject Areas on Research
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Activin expression by cultured human retinal pigment epithelial cells.
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Adenocarcinoma of the retinal pigment epithelium: a diagnostic and therapeutic challenge.
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Adenoma of the retinal pigment epithelium simulating a juxtapapillary choroidal neovascular membrane.
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Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cells.
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Age-related alterations in vitamin A metabolism in the rat retina.
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Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells.
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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.
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Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.
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Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.
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Autofluorescence of choroidal melanoma in 51 cases.
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Barriers to productive transfection of trabecular meshwork cells.
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Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.
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Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.
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Ca++-switch induction of RPE differentiation.
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Can chorio-retinal biopsy be justified?
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Caspase-8-mediated apoptosis in human RPE cells.
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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
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Characterization of a novel family of ciliary body glycoproteins.
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Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD.
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Clinical and functional findings in choroideremia due to complete deletion of the CHM gene.
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Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration.
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Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16.
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Combined hamartoma of the retina and retinal pigment epithelium: optical coherence tomography.
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Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report No. 15.
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Congenital ectropion uvea and mechanisms of glaucoma in neurofibromatosis type 1: new insights.
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Congenital fibrovascular pupillary membranes: clinical and histopathologic findings.
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Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE.
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Dietary vitamins A and E influence retinyl ester composition and content of the retinal pigment epithelium.
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Distinctive gene transduction efficiencies of commonly used viral vectors in the retina.
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Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.
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Drusen of the optic disc. A retrospective study in cadaver eyes.
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Dynamic Imaging of a Pigmented Free-Floating Vitreous Cyst.
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Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat.
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Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.
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Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.
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Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.
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Effects of indocyanine green on the retina and retinal pigment epithelium in a porcine model of retinal hole.
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Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane.
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Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.
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Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat.
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Experimental suprachoroidal plombage with a urethane based hydrophilic polymer.
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Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells.
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Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells.
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Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells.
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Extensive subretinal pigment epithelial deposit in two brothers suffering from dominant retinitis pigmentosa. A histopathological study.
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Extracellular matrix in aged human ciliary body: an immunoelectron microscope study.
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Exudative retinal detachment after photodynamic injury.
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Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice.
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Geographic atrophy in age-related macular degeneration and TLR3.
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Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7.
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Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy.
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Human RPE expression of cell survival factors.
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Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1.
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Hyalocytes synthesize and secrete inhibitors of retinal pigment epithelial cell proliferation in vitro.
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Hydrogen peroxide induces microvilli on human retinal pigment epithelial cells in culture.
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Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium.
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Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil.
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Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.
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L-DOPA is an endogenous ligand for OA1.
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Lactose supports Muller cell protein expression patterns in the absence of the retinal pigment epithelium.
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Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells.
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MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.
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MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover.
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Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.
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Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma.
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Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
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Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.
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Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity.
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Modulation of macrophage colony stimulating factor in cultured human retinal pigment epithelial cells.
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Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor.
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Monensin enhances the cytotoxic effect of antitransferrin receptor immunotoxin on cultured RPE cells.
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Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells.
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Multifocal posterior uveitis: clinical and pathological findings.
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Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial.
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Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity.
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Ocular reticulum cell sarcoma.
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Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients.
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Optical coherence tomography following photodynamic therapy with verteporfin for subfoveal predominantly classic choroidal neovascularization.
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Optical coherence tomography of congenital simple hamartoma of the retinal pigment epithelium.
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Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments.
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Ouabain-sensitive Na+-K+ ATPase pumps in cultured human retinal pigment epithelium.
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Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor.
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Oxidant-mediated Akt activation in human RPE cells.
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Oxidative damage-induced inflammation initiates age-related macular degeneration.
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PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.
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Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells.
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Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia.
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Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss.
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Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration.
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Permissive glycan support of photoreceptor outer segment assembly occurs via a non-metabolic mechanism.
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Photochemical initiation of thrombosis. Fluorescein angiographic, histologic, and ultrastructural alterations in the choroid, retinal pigment epithelium, and retina.
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Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography.
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Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.
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Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium.
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Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal.
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Pigmented paravenous retinochoroidal atrophy. Discordant expression in monozygotic twins.
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Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium.
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Primary adenocarcinoma of pigmented ciliary epithelium in a phthisical eye.
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Pseudomelanomas after conservative management of uveal melanoma.
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Quantitative assessment of growth stimulating activity of the vitreous during PVR.
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Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization.
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Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole.
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Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.
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Regulated heat shock protein 27 expression in human retinal pigment epithelium.
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Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.
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Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium.
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Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo.
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Retinal pathology in the Kearns-Sayre syndrome.
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Retinal pigment epithelial cells of the posterior pole have fewer Na/K adenosine triphosphatase pumps than peripheral cells.
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Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature.
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Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2.
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Retinitis pigmentosa: clinical management based on current concepts.
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Retinomotor movements in isolated teleost retinal cone inner-outer segment preparations (CIS-COS): effects of light, dark and dopamine.
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Spontaneous giant retinal pigment epithelial tear associated with panuveitis.
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Sub-retinal drusenoid deposits in human retina: organization and composition.
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Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells.
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Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor.
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Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis.
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Terminology of sub-RPE deposits: do we all speak the same language?
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The antiproliferative effect of a transferrin-toxin on human retinal pigment epithelial cells and rabbit fibroblasts.
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The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium.
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The effectiveness of latanoprost for the treatment of pediatric glaucoma.
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The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.
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The importance of Bcl-xL in the survival of human RPE cells.
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The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation.
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The surface oxidation potential of melanosomes measured by free electron laser-photoelectron emission microscopy.
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Topography of geographic atrophy in age-related macular degeneration.
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Transplantation of full-thickness retina in the rhodopsin transgenic pig.
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Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula.
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Understanding RPE Lipofuscin.
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[Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells].
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Keywords of People
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Bowes Rickman, Catherine,
Professor of Ophthalmology,
Cell Biology
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Cianciolo, George James,
Associate Professor in Pathology,
Pathology
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Fekrat, Sharon,
Professor of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
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Mruthyunjaya, Prithvi,
Adjunct Associate Professor in the Department of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
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Stinnett, Sandra Sue,
Associate Professor of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
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Toth, Cynthia Ann,
Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology,
Biomedical Engineering