Placenta

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  Subject Areas on Research

  • A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A gestational-age-independent model of birth weight based on placental size. 
  • A novel human endogenous retroviral protein inhibits cell-cell fusion. 
  • A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. I. Development. 
  • A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. II. Preliminary clinical application--the dehydroepiandrosterone loading test. 
  • A prospective blinded comparison of second trimester fetal measurements by expert and novice readers using low-cost novice-acquired 3D volumetric ultrasound. 
  • A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. 
  • A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Absence of Y chromosome in human placental site trophoblastic tumor. 
  • An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. 
  • Analysis of cleavage complexes using reactive inhibitor derivatives. 
  • Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation. 
  • Are epigenetic changes in the intrauterine environment related to newborn neurobehavior? 
  • Aspirin use during pregnancy and hypoxia-related placental pathology. 
  • Association of clinical signs of chorioamnionitis with histological chorioamnionitis and neonatal outcomes. 
  • Associations of intrauterine growth restriction with placental pathological factors, maternal factors and fetal factors; clinicopathological findings of 257 Japanese cases. 
  • Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization. 
  • Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. 
  • Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. 
  • Brominated flame retardants and legacy organochlorines in archived human placenta samples: Sex differences, temporal analysis and associations with infant birth weight. 
  • Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints. 
  • Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? 
  • Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Chromosomal localization of human glutamate receptor genes. 
  • Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. 
  • Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum. 
  • Clinical Correlates of Placenta Accreta Spectrum Disorder Depending on the Presence or Absence of Placenta Previa: A Systematic Review and Meta-analysis. 
  • Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. 
  • Comparative analysis of normal and growth-retarded placentas with phosphorus nuclear magnetic resonance spectroscopy. 
  • Comparison of Placental and Neonatal Admission Complete Blood Cell Count and Blood Cultures. 
  • Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. 
  • Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. 
  • Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes. 
  • Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues. 
  • Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? 
  • Covalent labelling of ligand binding sites of human placental S-adenosylhomocysteine hydrolase with 8-azido derivatives of adenosine and cyclic AMP. 
  • Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. 
  • Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Delivery risks and outcomes associated with grand multiparity. 
  • Diagnosis of placental malaria in poorly fixed and processed placental tissue. 
  • Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses. 
  • Differential effect of cyclic adenosine monophosphate on the secretion of human placental lactogen and human chorionic gonadotropin. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas. 
  • Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? 
  • Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo. 
  • Early onset preeclampsia in a model for human placental trophoblast. 
  • Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation. 
  • Editor's Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats. 
  • Effect of exogenous dehydroepiandrosterone upon the fetoplacental biosynthesis of estrogens and its effect upon uterine blood flow in the term pregnant ewe. 
  • Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain. 
  • Effects of maternal urban particulate matter SRM 1648a exposure on birth outcomes and offspring growth in mice. 
  • Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. 
  • Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. 
  • Emerging roles for lysophospholipid mediators in pregnancy. 
  • Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. 
  • Ethical aspects of banking placental blood for transplantation. 
  • Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model. 
  • Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX). 
  • Evaluation of the fiber-optic antibody-based fluoroimmunosensor for DNA adducts in human placenta samples. 
  • Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates. 
  • Evolution and antiviral activity of a human protein of retroviral origin. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance. 
  • Expression and trafficking of placental microRNAs at the feto-maternal interface. 
  • Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels. 
  • Expression of catalytically active human multifunctional glycogen-debranching enzyme and lysosomal acid alpha-glucosidase in insect cells. 
  • Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • Factors that influence the uptake and turnover of glucocerebrosidase and alpha-galactosidase in mammalian liver. 
  • Fetal exposure to the maternal microbiota in humans and mice. 
  • Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. 
  • Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats. 
  • First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. 
  • Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. 
  • Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. 
  • Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. 
  • GPER1 is required to protect fetal health from maternal inflammation. 
  • Gatekeepers of the fetus: Characterization of placental macrophages. 
  • Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. 
  • Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy. 
  • Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Hormone receptor complexes and their modulation of membrane function. 
  • How cytokines leave their mark: the role of the placenta in developmental programming of brain and behavior. 
  • Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines. 
  • Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. 
  • Human placental trophoblasts confer viral resistance to recipient cells. 
  • Hydrops fetalis associated with idiopathic arterial calcification. 
  • Hypertension in pregnancy and adverse outcomes among low-risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial. 
  • Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. 
  • Immune interactions at the maternal-fetal interface: a focus on antigen presentation. 
  • Immune responses at the maternal-fetal interface. 
  • Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases. 
  • Immunopathological and clinical studies in herpes gestationis. 
  • Infantile sialic acid storage disease: a rare cause of cytoplasmic vacuolation in pediatric patients. 
  • Infections at the maternal-fetal interface: an overview of pathogenesis and defence. 
  • Influence of maternal obesity and metabolic and vascular mediators in twin-twin transfusion syndrome. 
  • Innate immune defenses at the maternal-fetal interface. 
  • Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface. 
  • Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia. 
  • Intravillous eicosanoid compartmentalization and regulation of placental blood flow. 
  • Intravital imaging of mouse embryos. 
  • Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta. 
  • Is SARS-CoV-2 Infection a Risk Factor for Early Pregnancy Loss? ACE2 and TMPRSS2 Coexpression and Persistent Replicative Infection in Primitive Trophoblast. 
  • Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. 
  • Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. 
  • JCL Roundtable: Lipidology and Women's Health. 
  • Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • Liver-specific glucose-6-phosphatase is not present in human placenta. 
  • Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway. 
  • Malaria infection during pregnancy: intrauterine growth retardation and preterm delivery in Malawi. 
  • Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. 
  • Maternal diet disrupts the placenta-brain axis in a sex-specific manner. 
  • Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits. 
  • Maternal serum cytokines in preterm premature rupture of membranes. 
  • Mechanisms of Zika Virus Infection and Neuropathogenesis. 
  • Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. 
  • Metal ion levels in maternal and placental blood after metal-on-metal total hip arthroplasty. 
  • Microbial Vertical Transmission during Human Pregnancy. 
  • Microparasites and Placental Invasiveness in Eutherian Mammals. 
  • Modeling the Placenta with Stem Cells. 
  • Mortality conference: twin-to-twin transfusion. 
  • Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. 
  • New postcrania of Deccanolestes from the Late Cretaceous of India and their bearing on the evolutionary and biogeographic history of euarchontan mammals. 
  • No evidence for maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation. 
  • Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. 
  • Outcomes among 562 recipients of placental-blood transplants from unrelated donors. 
  • PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation. 
  • PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • Pathogenesis of hemangioma. 
  • Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast. 
  • Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes. 
  • Perspectives from Patients and Healthcare Providers on the Practice of Maternal Placentophagy. 
  • Phosphorus 31 magnetic resonance spectroscopy of human placenta and quantitation with perchloric acid extracts. 
  • Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex? 
  • Placental IDO and oxidative damage in pre-eclampsia: fresh chicken or fresh eggs? Preface. 
  • Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity. 
  • Placental autotaxin expression is diminished in women with pre-eclampsia. 
  • Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. 
  • Placental evaluation with magnetic resonance. 
  • Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia. 
  • Placental hormones and the control of fetal growth. 
  • Placental hormones and the control of maternal metabolism and fetal growth. 
  • Placental localisation with 99mTc-labelled red blood cells. 
  • Placental structural abnormalities in gestational diabetes and when they develop: A scoping review. 
  • Placental transfer and fetal distribution of 3H-retinoic acid in rats. 
  • Placental transport of free palmitic and linoleic acids in the guinea pig. 
  • Placental-blood transplantation. 
  • Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells. 
  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. 
  • Prediction of outcome in fetal autoimmune complete heart block. 
  • Preeclampsia: animal models for a human cure. 
  • Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid. 
  • Pregnancy outcomes after snakebite envenomations: A retrospective cohort in the Brazilian Amazonia. 
  • Prolactin receptor gene expression in the fetal rat. 
  • Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients. 
  • Proteolytic domains of the epidermal growth factor receptor of human placenta. 
  • Rapid Diagnostic Test Performance Assessed Using Latent Class Analysis for the Diagnosis of Plasmodium falciparum Placental Malaria. 
  • Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice. 
  • Review: human endogenous retroviruses and the placenta. 
  • Review: placenta-specific microRNAs in exosomes - good things come in nano-packages. 
  • Rift Valley fever virus induces fetal demise in Sprague-Dawley rats through direct placental infection. 
  • Risk factors for uteroplacental vascular compromise and inflammation. 
  • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. 
  • S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. 
  • SARS-CoV-2 Immunohistochemistry In Placenta. 
  • Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • Society for Maternal-Fetal Medicine Consult Series #60: Management of pregnancies resulting from in vitro fertilization. 
  • Sonographic Evaluation of the Placenta in Fontan Patients: A Case Series. 
  • State of the art in umbilical cord transplantation. 
  • Stem cell transplantation (cord blood transplants). 
  • Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase. 
  • Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy? 
  • TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. 
  • The Binding of Monoclonal and Polyclonal Anti-Z-DNA Antibodies to DNA of Various Species Origin. 
  • The Difference Between Unfixed and Postfixation Placental Weight. 
  • The Function of TrophomiRs and Other MicroRNAs in the Human Placenta. 
  • The Immunology of Syncytialized Trophoblast. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The Tree(s) of Life: The Human Placenta and My Journey to Learn More about It. 
  • The case for careful examination of the placenta. Helpful information from the delivery room. 
  • The fire of evolution: energy expenditure and ecology in primates and other endotherms. 
  • The functional diversity of tissue-resident natural killer cells against infection. 
  • The gestational membrane microbiome in the presence or absence of intraamniotic infection. 
  • The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations. 
  • The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • The placenta--an overlooked organ. 
  • The relationship between maternal anemia and umbilical cord oxygen content at delivery. 
  • The relationship of placental grade to fetal size and growth at term. 
  • The role of trophoblastic microRNAs in placental viral infection. 
  • The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior. 
  • The villous stromal constituents of complete hydatidiform mole differ histologically in very early pregnancy from the normally developing placenta. 
  • Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse. 
  • Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy. 
  • Trisomy 13-confined placental mosaicism: is there an increased risk of gestational hypertensive disorders? 
  • Twin-to-Twin Transfusion Syndrome: A Case Report. 
  • Type I interferons instigate fetal demise after Zika virus infection. 
  • Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. 
  • Type III Interferons in Antiviral Defenses at Barrier Surfaces. 
  • Unrelated placental blood in marrow transplantation. 
  • Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. 
  • Use of Placental/Umbilical Blood Sampling for Neonatal Admission Blood Cultures: Benefits, Challenges, and Strategies for Implementation. 
  • Use of multiple radioligands to characterize adenosine receptors in human placenta. 
  • Vasa previa: prenatal diagnosis by transperineal sonography with Doppler evaluation. 
  • Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters. 
  • Vulnerability of primitive human placental trophoblast to Zika virus. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • Zika virus - reigniting the TORCH. 
  • Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. 
  • cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bilbo, Staci D., Haley Family Professor of Psycology and Neuroscience, Psychology & Neuroscience
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gilner, Jennifer B, Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology