Plasma

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  Subject Areas on Research

  • A comparison of adverse reaction rates for PAS C versus plasma platelet units. 
  • A massive transfusion protocol incorporating a higher FFP/RBC ratio is associated with decreased use of recombinant activated factor VII in trauma patients. 
  • A placebo-controlled trial of ranitidine in patients with early human immunodeficiency virus infection. 
  • A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. 
  • A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice. 
  • Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency. 
  • Acylcarnitines: analysis in plasma and whole blood using tandem mass spectrometry. 
  • Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. 
  • Alterations in viscosity and filterability of whole blood and blood cell subpopulations in diabetic cats. 
  • Alternate analysis strategies for retrospective assessment of outcomes with a male donor-only plasma policy. 
  • Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. 
  • Analytic bias of thyroid function tests: analysis of a College of American Pathologists fresh frozen serum pool by 3900 clinical laboratories. 
  • Anaphylactic reactions to plasma infusions in patients with hypogammaglobulinemia and anti-IgA antibodies. 
  • Anti-Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease. 
  • Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin. 
  • Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial. 
  • Apheresis for collection of Ebola convalescent plasma in Liberia. 
  • Aprotinin use during cardiac surgery: recent alterations and effects on blood product utilization. 
  • Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. 
  • Association of exome sequences with plasma C-reactive protein levels in >9000 participants. 
  • Biology of Factor XIII and clinical manifestations of Factor XIII deficiency. 
  • COVID-19 convalescent plasma: Interim recommendations from the AABB. 
  • COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. 
  • Catch those antibodies before they fall. 
  • Changes in plasma unit distributions to hospitals over a 10-year period. 
  • Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys. 
  • Characterization of human immunodeficiency virus type 1 in saliva and blood plasma by V3-specific heteroduplex tracking assay and genotype analyses. 
  • Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. 
  • Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction. 
  • Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. 
  • Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. 
  • Comparison of fresh frozen serum to proficiency testing material in College of American Pathologists surveys: alpha-fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin, and prostate-specific antigen. 
  • Comparison of fresh frozen serum to traditional proficiency testing material in a College of American Pathologists survey for ferritin, folate, and vitamin B12. 
  • Comparison of pooled fresh frozen serum to proficiency testing material in College of American Pathologists surveys: cortisol and immunoglobulin E. 
  • Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation. 
  • Creatinine measurement: state of the art in accuracy and interlaboratory harmonization. 
  • Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. 
  • Defining Usage and Clinical Outcomes Following Perioperative Fresh Frozen Plasma and Platelet Administration in Spine Surgery Patients. 
  • Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model. 
  • Earlier the better: convalescent plasma. 
  • Effects of a plasma-derived C1 esterase inhibitor on hemostatic activation, clot formation, and thrombin generation. 
  • Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. 
  • Effects of cold exposure and dehydration on renal function in black-tailed prairie dogs. 
  • Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. 
  • Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease. 
  • Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. 
  • Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. 
  • Enzymatically Degassed Surface-Initiated Atom Transfer Radical Polymerization with Real-Time Monitoring. 
  • Enzyme-Linked Immunoassay-Based Quantitative Measurement of Apolipoprotein B (ApoB) in Dried Blood Spots, a Biomarker of Cardiovascular Disease Risk. 
  • Establishing lymphoblastoid cell lines from frozen blood of extremely old individuals. 
  • Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. 
  • Evaluation of effect of scheduled fresh frozen plasma on ECMO circuit life: A randomized pilot trial. 
  • Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific. 
  • Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature Review. 
  • Factor concentrates for perioperative bleeding: old drugs with new approaches. 
  • Factors associated with red blood cell, platelet, and plasma transfusions among inpatient hospitalizations: a nationally representative study in the United States. 
  • Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. 
  • Fibrinogen content of low-volume cryoprecipitate. 
  • Fluconazole loading dose pharmacokinetics and safety in infants. 
  • Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young. 
  • HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS. 
  • HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. 
  • HPLC enrichment/isolation of proteins for post-translational modification studies from complex mixtures. 
  • Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage. 
  • High specific infectivity of plasma virus from the pre-ramp-up and ramp-up stages of acute simian immunodeficiency virus infection. 
  • How did we rapidly implement a convalescent plasma program? 
  • Immunoreconstitution. 
  • Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. 
  • In vitro comparative study of hemostatic components in warfarin-treated and fibrinogen-deficient plasma. 
  • Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpura. 
  • Increased anticoagulant activity of thrombin-binding DNA aptamers by nanoscale organization on DNA nanostructures. 
  • Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. 
  • Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. 
  • Infectious complications after cardiac surgery: lack of association with fresh frozen plasma or platelet transfusions. 
  • Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia. 
  • International normalized ratio. 
  • Is there a precursive, relatively procoagulant-inactive form of normal antihemophilic factor (factor VIII)? 
  • Lactate measured in diluted and undiluted whole blood and plasma: comparison of methods and effect of hematocrit. 
  • Largazole pharmacokinetics in rats by LC-MS/MS. 
  • Large scale purification of factor X by hydrophobic chromatography. 
  • Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients. 
  • Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230. 
  • Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature. 
  • Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial. 
  • Many, but not all, outcome studies support exclusion of female plasma from the blood supply. 
  • NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation. 
  • No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery. 
  • Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. 
  • PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. 
  • Perception of low-titer group A plasma and potential barriers to using this product: A blood center's experience serving community and academic hospitals. 
  • Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. 
  • Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants. 
  • Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. 
  • Plasma therapy in immunodeficiency diseases. 
  • Plasma therapy in immunodeficiency diseases. 
  • Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects. 
  • Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. 
  • Posttransfusion thrombocytopenia: a cautionary tale of female group AB plasma. 
  • Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease. 
  • Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature. 
  • Purification and subunit structure of human plasma and platelet fibrin-stabilizing factor. 
  • Rapid disappearance of nitroglycerin following incubation with human blood. 
  • Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Recycle: Do It for the Kids. 
  • Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. 
  • Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. 
  • Responding to the immunoglobulin shortage: a case study. 
  • Reversal of warfarin associated coagulopathy with 4-factor prothrombin complex concentrate in traumatic brain injury and intracranial hemorrhage. 
  • Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. 
  • Sex-related difference in the metabolism of isosorbide dinitrate following incubation in human blood. 
  • Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes. 
  • Solvent-detergent-treated fresh frozen plasma: a superior alternative to standard fresh frozen plasma? 
  • Systematic review of the performance of HIV viral load technologies on plasma samples. 
  • The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients. 
  • The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation. 
  • The effect of surface contact activation and temperature on plasma coagulation with an RNA aptamer directed against factor IXa. 
  • The reactivity of paired plasma and serum samples are comparable in the anticardiolipin and anti-beta2-glycoprotein-1 ELISAs. 
  • The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis. 
  • Therapeutic Plasma Transfusion in Bleeding Patients: A Systematic Review. 
  • Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children. 
  • Total long-term within-laboratory precision of cortisol, ferritin, thyroxine, free thyroxine, and thyroid-stimulating hormone assays based on a College of American Pathologists fresh frozen serum study: do available methods meet medical needs for precision? 
  • Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. 
  • Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. 
  • Traumatic brain injury and hemorrhagic shock: evaluation of different resuscitation strategies in a large animal model of combined insults. 
  • Treatment Strategies for Deficiency of Adenosine Deaminase 2. 
  • Two forms of HLA class I molecules in human plasma. 
  • Using Plasma and Prothrombin Complex Concentrates. 
  • Variability in the fibrinogen and von Willebrand factor content of cryoprecipitate. Implications for reducing donor exposure. 
  • Variation in use of blood transfusion in coronary artery bypass graft surgery. 
  • Viscoelastic response of a model endothelial glycocalyx. 
  • Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial. 
  • Warfarin reversal with prothrombin complex concentrate confers better antifibrinolytic activity compared with recombinant activated factor VII. 
  • What Is the PROPPR Transfusion Strategy in Trauma Resuscitation? 
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  Keywords of People

  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic