Plasmodium

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  Subject Areas on Research

  • A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity. 
  • A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. 
  • A quality control program within a clinical trial Consortium for PCR protocols to detect Plasmodium species. 
  • Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts. 
  • Chemical interrogation of the malaria kinome. 
  • Clinical evaluation of the BioFire Global Fever Panel for the identification of malaria, leptospirosis, chikungunya, and dengue from whole blood: a prospective, multicentre, cross-sectional diagnostic accuracy study. 
  • Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity. 
  • Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women. 
  • Current therapies and future possibilities for drug development against liver-stage malaria. 
  • Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage. 
  • Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. 
  • Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection. 
  • Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. 
  • Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya. 
  • Evaluation of the interaction between insecticide resistance-associated genes and malaria transmission in Anopheles gambiae sensu lato in central Côte d'Ivoire. 
  • High-throughput pooling and real-time PCR-based strategy for malaria detection. 
  • Host resistance to malaria: using mouse models to explore the host response. 
  • Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/Pf PK6 with Activity against Blood Stage Parasites In Vitro. 
  • Malaria parasites and red cell variants: when a house is not a home. 
  • Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria. 
  • Multiplex 5' nuclease quantitative real-time PCR for clinical diagnosis of malaria and species-level identification and epidemiologic evaluation of malaria-causing parasites, including Plasmodium knowlesi. 
  • Out of the net: An agent-based model to study human movements influence on local-scale malaria transmission. 
  • Pilot assessment of the sensitivity of the malaria thin film. 
  • Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. 
  • Plasmodium's fight for survival: escaping elimination while acquiring nutrients. 
  • Primate malarias as a model for cross-species parasite transmission. 
  • Production and validation of durable, high quality standardized malaria microscopy slides for teaching, testing and quality assurance during an era of declining diagnostic proficiency. 
  • Protein kinases of malaria parasites: an update. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Reader technique as a source of variability in determining malaria parasite density by microscopy. 
  • Strain theory of malaria: the first 50 years. 
  • The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs. 
  • The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. 
  • Thermal biology of mosquito-borne disease. 
  • malERA: An updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication.