Platelet Activating Factor
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Subject Areas on Research
- A facile synthesis of 1-O-alkyl-2-(R)-hydroxypropane-3-phosphonocholine (lyso-phosphono-platelet activating factor).
- Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils.
- Altered inflammatory responses in leukotriene-deficient mice.
- Altered mitochondrial redox responses in gram negative septic shock in primates.
- An endogenous source of the superoxide anion in the central nervous system.
- Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat.
- BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models.
- Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban.
- Chemoattractant-induced activation of c-fos gene expression in human monocytes.
- Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor.
- Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils.
- Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.
- Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
- Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat.
- Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.
- Diarrhea, demography and cell signaling: lessons from microbial toxins.
- Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver.
- Evidence for platelet-activating factor secretion during immune activation in dogs.
- Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo.
- Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase.
- Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
- Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
- Molecular mechanisms of leukocyte activation by chemoattractants.
- PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo.
- Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
- Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.
- Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis.
- Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung.
- RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
- Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases.
- Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
- Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs.
- Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo.
- Role of neutrophils in breakdown of the blood-retinal barrier following intravitreal injection of platelet-activating factor.
- Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor.
- Role of platelet activating factor in kidney transplant rejection in the rat.
- Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A.
- Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin.
- Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin.
- Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung.
- Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
- The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs.
- Translation and Clinical Development of Antithrombotic Aptamers.
- Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts.