Platelet-Derived Growth Factor
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Subject Areas on Research
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A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells.
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A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration.
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A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
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A phase I dose-escalation study of imatinib mesylate (Gleevec/STI571) plus capecitabine (Xeloda) in advanced solid tumors.
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A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: a trial of the Princess Margaret Hospital phase II consortium.
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A platelet-derived growth factor homolog secreted by alveolar macrophages is complexed to an alpha-macroglobulin.
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ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis.
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Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
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Activation of pp60c-src is necessary for human vascular smooth muscle cell migration.
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Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms.
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Aggressive fibromatosis.
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Alpha-macroglobulin secreted by alveolar macrophages serves as a binding protein for a macrophage-derived homologue of platelet-derived growth factor.
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Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation.
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Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies.
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Cell adhesion: separation of p120's powers?
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Cell death and control of cell survival in the oligodendrocyte lineage.
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Cell death in the oligodendrocyte lineage.
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Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma.
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Cisplatin, irinotecan, and bevacizumab for untreated extensive-stage small-cell lung cancer: CALGB 30306, a phase II study.
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Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins.
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Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma.
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Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels.
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Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
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Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells.
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Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.
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Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling.
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Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration: A Phase IIb, Multicenter, Randomized Controlled Trial.
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EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
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Effects of partially and more highly purified platelet-derived growth factor preparations on luteinizing hormone receptor induction in granulosa cell cultures.
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Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression.
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Endothelial progenitor cells induce a phenotype shift in differentiated endothelial cells towards PDGF/PDGFRβ axis-mediated angiogenesis.
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Expression of TGFalpha in meningiomas.
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Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture.
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Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.
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Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.
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Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
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Human platelet-derived growth factor preparations contain a separate activity which potentiates follicle-stimulating hormone-mediated induction of luteinizing hormone receptor in cultured rat granulosa cells: evidence for transforming growth factor-beta.
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IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.
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Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
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Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.
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Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension.
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Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism.
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Insulin-like growth factor-I is expressed by avian flexor tendon cells.
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Ligation of the alpha2M signalling receptor elevates the levels of p21Ras-GTP in macrophages.
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Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms.
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Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.
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Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia.
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Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.
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Nicotine increases size and severity of experimental choroidal neovascularization.
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Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
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Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.
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P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.
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PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment.
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PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro.
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PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized alpha 2-macroglobulin.
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Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.
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Phase 2 studies of sunitinib and AG013736 in patients with cytokine-refractory renal cell carcinoma.
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Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
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Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum.
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Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures.
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
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Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.
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Platelet-derived growth factor receptors: a therapeutic target in solid tumors.
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Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons.
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Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.
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Potential treatment for clubfeet based on growth factor blockade.
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Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.
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Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization.
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Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
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Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle.
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Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain.
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Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle.
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Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
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Role of vascular mitogens in subarachnoid hemorrhage-associated cerebral vasculopathy.
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Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing.
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Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase.
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Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.
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Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis.
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Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
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Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
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TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity.
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Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.
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The expression of platelet-derived growth-factor gene in Dupuytren contracture.
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The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.
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The role of Smad3 in mediating mouse hepatic stellate cell activation.
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The role of integrins in saphenous vein vascular smooth muscle cell migration.
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The role of peptide growth factors in epithelial ovarian cancer.
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Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.
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Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.
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Vatalanib in malignant mesothelioma: a phase II trial by the Cancer and Leukemia Group B (CALGB 30107).
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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.
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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
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p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts.
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p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics