Platinum

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  Subject Areas on Research

  • A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer. 
  • A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904. 
  • A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer. 
  • Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors. 
  • Activity of various endogenous compounds and pharmacologic agents at a glucose-oxidizing platinum electrode. 
  • Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer. 
  • Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment. 
  • Complexes of serum albumin and cis-dichlorodiammineplatinum (II). The role of cysteine 34 as a nucleophilic entering group and evidence for reaction between bound platinum and a second macromolecule. 
  • Coordination-induced formation of submicrometer-scale, monodisperse, spherical colloids of organic-inorganic hybrid materials at room temperature. 
  • Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin. 
  • Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer. 
  • Cost-effectiveness of combination versus sequential docetaxel and carboplatin for the treatment of platinum-sensitive, recurrent ovarian cancer. 
  • Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. 
  • Detection of hydrazine, methylhydrazine and isoniazid by capillary electrophoresis with a 4-pyridyl hydroquinone self-assembled microdisk platinum electrode. 
  • Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs. 
  • Electrochemical activation of electrodes for amperometric detection of nitric oxide. 
  • Electrochemical detection of nitric oxide in biological fluids. 
  • Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays. 
  • Endovascular platinum coil embolization of incompletely surgically clipped cerebral aneurysms. 
  • Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA-mutated prostate cancers. 
  • Fluorouracil and leucovorin in advanced breast cancer. 
  • Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy. 
  • Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy. 
  • Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model. 
  • Interaction of K7Fe3+P2W17O62H2 with supported bilayer lipid membranes on platinum electrode. 
  • New technique for capillary electrophoresis directly coupled with end-column electrochemiluminescence detection. 
  • Olaparib With or Without Cediranib Versus Platinum-Based Chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer (NRG-GY004): A Randomized, Open-Label, Phase III Trial. 
  • Palladium(II)- and platinum(II)-catalyzed addition of stabilized carbon nucleophiles to ethylene and propylene. 
  • Pazopanib maintenance after first-line etoposide and platinum chemotherapy in patients with extensive disease small-cell lung cancer: a multicentre, randomised, placebo-controlled Phase II study (KCSG-LU12-07). 
  • Pharmacokinetics of cis-diamminedichloroplatinum(II) after administration in hypertonic saline. 
  • Platinum sensitivity in metastatic prostate cancer: does histology matter? 
  • Platinum(II)-catalyzed intermolecular hydroamination of monosubstituted allenes with secondary alkylamines. 
  • Platinum(II)-catalyzed intermolecular hydroarylation of unactivated alkenes with indoles. 
  • Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles. 
  • Platinum-catalyzed intramolecular alkylation of indoles with unactivated olefins. 
  • Platinum-catalyzed intramolecular hydroalkoxylation of gamma- and delta-hydroxy olefins to form cyclic ethers. 
  • Platinum/taxane-based chemotherapy with or without radiation therapy favorably impacts survival outcomes in stage I uterine papillary serous carcinoma. 
  • Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients. 
  • Predictors of Physical and Functional Loss in Advanced-Stage Lung Cancer Patients Receiving Platinum Chemotherapy. 
  • Prospective Single-Arm Phase 1 and 2 Study: Ipilimumab and Nivolumab With Thoracic Radiation Therapy After Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer. 
  • Purified lac permease and cytochrome o oxidase are functional as monomers. 
  • Real-world treatment patterns of maintenance therapy in platinum-sensitive recurrent ovarian cancer. 
  • Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer. 
  • Rigid and flexible thin-film multielectrode arrays for transmural cardiac recording. 
  • Small-molecule dynamics and mechanisms underlying the macroscopic mechanical properties of coordinatively cross-linked polymer networks. 
  • Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies. 
  • Structure and thermomechanical behavior of NiTiPt shape memory alloy wires. 
  • Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • Transcatheter electrocoagulation: experimental evaluation of the anode. 
  • Veliparib and nivolumab in combination with platinum doublet chemotherapy in patients with metastatic or advanced non-small cell lung cancer: A phase 1 dose escalation study. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology