Poly Adenosine Diphosphate Ribose

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  Subject Areas on Research

  • Assay for protein modification by poly-ADP-ribose in vitro. 
  • DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. 
  • Endogenous polymers of ADP-ribose are associated with the nuclear matrix. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. 
  • Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.