Poly I-C

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  Subject Areas on Research

  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex. 
  • Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C). 
  • Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. 
  • Inhibition of HIV-1 proviral DNA synthesis and RNA accumulation by mismatched dsRNA. 
  • Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant. 
  • Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture. 
  • Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus. 
  • Mismatched dsRNA (ampligen) induces protection against genomic variants of the human immunodeficiency virus type 1 (HIV-1) in a multiplicity of target cells. 
  • Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. 
  • Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter. 
  • Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages. 
  • Postinfection therapy of arbovirus infections in mice. 
  • Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung. 
  • Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. 
  • Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles. 
  • The RNA binding protein Quaking represses host interferon response by downregulating MAVS. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. 
  • Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer. 
  • Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis.