Polyamines

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  Subject Areas on Research

  • A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. 
  • A link between urease and polyamine metabolism in Cryptococcus neoformans. 
  • A simplified method for isocratic HPLC analysis of polyamines. 
  • Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels. 
  • An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules 
  • Biochemical determinants of growth sparing during neonatal nutritional deprivation or enhancement: ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart. 
  • Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics. 
  • Coordination of cell development by the ornithine decarboxylase (ODC)/polyamine pathway as an underlying mechanism in developmental neurotoxic events. 
  • Development of polyamine and biogenic amine systems in brains and hearts of neonatal rats given dexamethasone: role of biochemical alterations in cellular maturation for producing deficits in ontogeny of neurotransmitter levels, uptake, storage and turnover. 
  • Differential effects of parenteral nutrition on tumor growth and erythrocyte polyamine levels in the rat. 
  • Direct tris(2,2'-bipyridyl)ruthenium (II) electrochemiluminescence detection of polyamines separated by capillary electrophoresis. 
  • Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. 
  • Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition. 
  • Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma. 
  • Effects of glutathione or polyamine depletion on in vivo thermosensitization. 
  • Effects of phosphate binders in moderate CKD. 
  • Erythrocyte polyamine levels during intravenous feeding of patients with colorectal carcinoma. 
  • Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. 
  • Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine. 
  • Influence of total parenteral nutrition on tumor growth and polyamine biosynthesis of fibrosarcoma-bearing rats after induced cachexia. 
  • Inhibition of the beta-adrenergic receptor kinase by polyanions. 
  • Methionine metabolism in health and cancer: a nexus of diet and precision medicine. 
  • Methylthioadenosine Suppresses Salmonella Virulence. 
  • Modulation of inositol phospholipid metabolism by polyamines. 
  • Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. 
  • Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. 
  • Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. 
  • Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. 
  • Nutritional parameters affecting erythrocyte polyamine levels in cancer patients. 
  • Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling. 
  • Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Ornithine decarboxylase as a tool in developmental neurobiology. 
  • Polyamine metabolism in carcinoma of the oral cavity compared with adjacent and normal oral mucosa. 
  • Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate. 
  • Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts. 
  • Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block. 
  • Polyamines as intermediates in developmental neurotoxic events. 
  • Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase. 
  • Polycationic Nanofibers for Nucleic Acid Scavenging. 
  • Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. 
  • Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion. 
  • Reduced cell death in skin flaps in rats treated with difluoromethylornithine. 
  • Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats. 
  • Repair of oxygen-induced lung injury in adult rats. The role of ornithine decarboxylase and polyamines. 
  • Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. 
  • Role of ornithine decarboxylase and the polyamines in nervous system development: a review. 
  • Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. 
  • Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations. 
  • Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. 
  • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. 
  • Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration. 
  • The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial. 
  • The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects. 
  • The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction. 
  • Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. 
  • Transgenic manipulation of the metabolism of polyamines in poplar cells. 
  • Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis. 
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  Keywords of People

  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma