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Subject Areas on Research
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2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.
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Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines.
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Antifungals in Clinical Use and the Pipeline.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Copper-Catalyzed Three-Component Aminofluorination of Alkenes and 1,3-Dienes: Direct Entry to Diverse β-Fluoroalkylamines.
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Current options in antifungal pharmacotherapy.
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Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.
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Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo.
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Exploring chemical space with discrete, gradient, and hybrid optimization methods.
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Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
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Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.
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Letter: Polyene antibiotics. VI. The structures of dermostatins A and B.
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Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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New facets of antifungal therapy.
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Pharmacokinetics of antifungal agents in children.
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Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.
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Rapamycin suppression of host-versus-graft and graft-versus-host disease in MHC-mismatched rats.
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Regulatory mechanisms of a chemoattractant receptor on human polymorphonuclear leukocytes.
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Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss.
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TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
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The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
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The structures of dermostatins A and B 1,2.
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Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.