Polysaccharides

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  Subject Areas on Research

  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus. 
  • A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. 
  • A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes. 
  • A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality. 
  • A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans. 
  • A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans. 
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. 
  • A rare cutaneous manifestation of hemorrhagic bullae to low-molecular-weight heparin and fondaparinux: report of two cases. 
  • AIDS/HIV. Host controls of HIV neutralizing antibodies. 
  • Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family. 
  • Acute testicular torsion: comparison of unenhanced and contrast-enhanced power Doppler US, color Doppler US, and radionuclide imaging. 
  • Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials. 
  • AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica. 
  • Affinity chromatography of beta-hydroxybutyrate dehydrogenase on Nad and hydrophobic chain derivatives of sepharose. 
  • AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein. 
  • An N-linked tetrasaccharide from Halobacterium salinarum presents a novel modification, sulfation of iduronic acid at the O-3 position. 
  • An important role of l-fucose biosynthesis and protein fucosylation genes in Arabidopsis immunity. 
  • Anti-polyribosylribitol phosphate antibody levels 5 years after a primary series of Haemophilus influenzae type B conjugate vaccine. 
  • Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. 
  • Antibody responses to the HIV-1 envelope high mannose patch. 
  • Anticoagulant therapy during primary percutaneous coronary intervention for acute myocardial infarction: a meta-analysis of randomized trials in the era of stents and P2Y12 inhibitors. 
  • Anticoagulant therapy for percutaneous coronary intervention. 
  • Antiplatelet and anticoagulation agents in acute coronary syndromes: what is the current status and what does the future hold? 
  • Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 
  • Antithrombotic therapy with fondaparinux in relation to interventional management strategy in patients with ST- and non-ST-segment elevation acute coronary syndromes: an individual patient-level combined analysis of the Fifth and Sixth Organization to Assess Strategies in Ischemic Syndromes (OASIS 5 and 6) randomized trials. 
  • Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate. 
  • Atomic levers control pyranose ring conformations. 
  • Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants. 
  • Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. 
  • Biological activity of agarose-immobilized catecholamines. 
  • Bleeding in acute coronary syndromes. 
  • CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. 
  • CD4 receptor diversity in chimpanzees protects against SIV infection. 
  • Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. 
  • Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. 
  • Carbohydrate cytochemistry by transmission and scanning electron microscopy. 
  • Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection. 
  • Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM. 
  • Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes. 
  • Characterization of mediators of insulin action. 
  • Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes. 
  • Comparison of fondaparinux and enoxaparin in acute coronary syndromes. 
  • Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth. 
  • Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism. 
  • Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans. 
  • Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death. 
  • Cryptococcus neoformans: virulence and host defences. 
  • Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies. 
  • Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA. 
  • Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E. 
  • Direct detection of inter-residue hydrogen bonds in polysaccharides by single-molecule force spectroscopy. 
  • Dismantling the Cryptococcus coat. 
  • Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein. 
  • Distribution and significance of hyaluronidase-sensitive materials in the trabecular wall of Schlemm's canal. 
  • Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid. 
  • Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis. 
  • Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes. 
  • Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis. 
  • Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment. 
  • Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. 
  • Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial. 
  • Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. 
  • Elevated factor VIII enhances thrombin generation in the presence of factor VIII-deficiency, factor XI-deficiency or fondaparinux. 
  • Engineering AAV receptor footprints for gene therapy. 
  • Equilibrium sampling for biomolecules under mechanical tension. 
  • Evidence for Differential Glycosylation of Trophoblast Cell Types. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Expert consensus on treatment strategies in non- ST-segment elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention--an evidence-based review of clinical trial results and treatment guidelines from an emergency medicine perspective: report on a roundtable discussion. 
  • Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells. 
  • Extension of O-Linked Mannosylation in the Golgi Apparatus Is Critical for Cell Wall Integrity Signaling and Interaction with Host Cells in Cryptococcus neoformans Pathogenesis. 
  • Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. 
  • Feasibility study: real-time 3-D ultrasound imaging of the brain. 
  • Fingerprinting polysaccharides with single-molecule atomic force microscopy. 
  • Fondaparinux compared to enoxaparin in patients with acute coronary syndromes without ST-segment elevation: outcomes and treatment effect across different levels of risk. 
  • Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II. 
  • Fondaparinux with UnfracTionated heparin dUring Revascularization in Acute coronary syndromes (FUTURA/OASIS 8): a randomized trial of intravenous unfractionated heparin during percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes initially treated with fondaparinux. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Glycan binding avidity determines the systemic fate of adeno-associated virus type 9. 
  • Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. 
  • Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. 
  • HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies. 
  • Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer. 
  • Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation. 
  • High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection. 
  • Human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function. 
  • Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • Immunization against Haemophilus influenzae. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Improving clinical outcomes by reducing bleeding in patients with non-ST-elevation acute coronary syndromes. 
  • In vitro biological activities of echinonectin. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. 
  • Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. 
  • Inhibition of Factor Xa : a potential target for the development of new anticoagulants. 
  • Intracellular mediators of insulin action. 
  • Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields. 
  • Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses. 
  • Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial. 
  • KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. 
  • Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. 
  • LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus. 
  • Landscape of stimulation-responsive chromatin across diverse human immune cells. 
  • Letter: Insulin activity: the solid matrix. 
  • Life is sweet: the cell biology of glycoconjugates. 
  • Localization of cell wall polysaccharides in nonarticulated laticifers of Asclepias speciosa Torr. 
  • Metabolic glycan labeling and chemoselective functionalization of native biomaterials. 
  • Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. 
  • Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. 
  • Molecular dynamics simulations of forced conformational transitions in 1,6-linked polysaccharides. 
  • Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. 
  • N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus. 
  • Nanomechanical control of glucopyranose rotamers. 
  • Novel constructs for thrombin inhibition. 
  • Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression. 
  • Oral Iron Therapy for Heart Failure With Reduced Ejection Fraction: Design and Rationale for Oral Iron Repletion Effects on Oxygen Uptake in Heart Failure. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization. 
  • P- and L-selectin mediate distinct but overlapping functions in endotoxin-induced leukocyte-endothelial interactions in the rat mesenteric microcirculation. 
  • Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries. 
  • Pathogenesis of Cryptococcus neoformans is associated with quantitative differences in multiple virulence factors. 
  • Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia. 
  • Pharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery: a randomized pilot feasibility trial. 
  • Phosphatidylinositol-glycan linked proteins of the erythrocyte membrane. 
  • Polymer hydrogels: Chaperoning vaccines. 
  • Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring. 
  • Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. 
  • Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. 
  • Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation. 
  • Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation. 
  • Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial. 
  • Receptor Switching in Newly Evolved Adeno-associated Viruses. 
  • Relationship between baseline haemoglobin and major bleeding complications in acute coronary syndromes. 
  • Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Self-organization of apical membrane protein sorting in epithelial cells. 
  • Simulating force-induced conformational transitions in polysaccharides with the SMD replica exchange method. 
  • Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts. 
  • Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Strain variation in composition and molecular size of the capsular polysaccharide of Cryptococcus neoformans serotype A. 
  • Stretching single molecules into novel conformations using the atomic force microscope. 
  • Stretching single polysaccharides and proteins using atomic force microscopy. 
  • Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. 
  • Structure and immune recognition of trimeric pre-fusion HIV-1 Env. 
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 
  • Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans. 
  • Sweet modification and regulation of death receptor signalling pathway. 
  • Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition. 
  • Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses. 
  • Technical problems with agarose-hormone linkage. 
  • The Cryptococcus neoformans capsule: a sword and a shield. 
  • The Editor's Roundtable: arterial thrombosis and acute coronary syndromes. 
  • The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization. 
  • The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. 
  • The micro-mechanics of single molecules studied with atomic force microscopy. 
  • The release of acid phosphatase and polysaccharide- and protein-containing components from the surface of the dimorphic forms of Candida albicans by treatment with dithiothreitol. 
  • Thromboprophylaxis with fondaparinux in high-risk postoperative patients with renal insufficiency. 
  • Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens. 
  • Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates. 
  • Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. 
  • Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site. 
  • Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. 
  • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. 
  • [In vitro studies on antioxidant and antimicrobial activities of polysaccharide from Lycoris aurea]. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology