Porphyrins

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  Subject Areas on Research

  • A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics. 
  • A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin. 
  • Adverse reaction characterized by chest pain, shortness of breath, and syncope associated with verteporfin (visudyne). 
  • Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity. 
  • An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways. 
  • An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin. 
  • Anemia due to inadequate iron sources or poor iron utilization. 
  • Antibody-targeted photodynamic therapy. 
  • Black stool. Some light on a dark subject. 
  • Boronic acid porphyrin receptor for ginsenoside sensing. 
  • Broad spectral domain fluorescence wavelength modulation of visible and near-infrared emissive polymersomes. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues. 
  • Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with ⁵⁷ Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors. 
  • Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. 
  • De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. 
  • De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. 
  • De novo design of a single-chain diphenylporphyrin metalloprotein. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. 
  • Detection of organophosphate flame retardants in furniture foam and U.S. house dust. 
  • Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Direct evaluation of electronic coupling mediated by hydrogen bonds: implications for biological electron transfer. 
  • Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab. 
  • Effects of Manganese Porphyrins on Cellular Sulfur Metabolism. 
  • Efficacy and Safety of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial. 
  • Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation. 
  • Ethyne-bridged (porphinato)zinc(II)-(porphinato)iron(III) complexes: phenomenological dependence of excited-state dynamics upon (porphinato)iron electronic structure. 
  • Exceptional near-infrared fluorescence quantum yields and excited-state absorptivity of highly conjugated porphyrin arrays. 
  • Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy 
  • From ionic liquids to supramolecular polymers. 
  • Functional changes after photodynamic therapy with verteporfin. 
  • Generalized Mulliken-Hush analysis of electronic coupling interactions in compressed pi-stacked porphyrin-bridge-quinone systems. 
  • H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. 
  • High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. 
  • Highly conjugated, acetylenyl bridged porphyrins: new models for light-harvesting antenna systems. 
  • Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure. 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization. 
  • Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Manganese superoxide dismutase, MnSOD and its mimics. 
  • Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury. 
  • Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo. 
  • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 
  • Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. 
  • Neuropsychiatric manifestations of porphyria. 
  • New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. 
  • Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore. 
  • Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents. 
  • Optical coherence tomography following photodynamic therapy with verteporfin for subfoveal predominantly classic choroidal neovascularization. 
  • Orientational Dependence of Cofacial Porphyrin-Quinone Electronic Interactions within the Strong Coupling Regime 
  • Photodynamic modulation of wound healing with BPD-MA and CASP. 
  • Photodynamic therapy for predominantly hemorrhagic lesions in neovascular age-related macular degeneration. 
  • Photodynamic treatment in a rabbit model of glaucoma surgery. 
  • Photoinitiated destruction of composite porphyrin-protein polymersomes. 
  • Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. 
  • Quasi-ohmic single molecule charge transport through highly conjugated meso-to-meso ethyne-bridged porphyrin wires. 
  • RADIANCE: a randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia. 
  • Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results. 
  • Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. 
  • Real-Time Visualization of the Precipitation and Phase Behavior of Octaethylporphyrin in Lipid Microparticles. 
  • Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme. 
  • Regression of extrafoveal choroidal osteoma following photodynamic therapy. 
  • Resolution of advanced cystoid macular edema following photodynamic therapy for choroidal hemangioma. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes. 
  • Retrospective review of eyes with neovascular age-related macular degeneration treated with photodynamic therapy with verteporfin and intravitreal triamcinolone. 
  • Rotational isomers of N-alkylpyridylporphyrins and their metal complexes. HPLC separation, (1)H NMR and X-ray structural characterization, electrochemistry, and catalysis of O(2)(.-) disproportionation. 
  • Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore. 
  • Sensing membrane stress with near IR-emissive porphyrins. 
  • Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. 
  • Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Sirohydrochlorin. Prosthetic group of a sulfite reductase enzyme and its role in the biosynthesis of vitamin B12. 
  • Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. 
  • Superoxidized states of Escherichia coli sulfite reductase heme protein subunit. 
  • THREE-YEAR RESULTS OF POLYPOIDAL CHOROIDAL VASCULOPATHY TREATED WITH PHOTODYNAMIC THERAPY: Retrospective Study and Systematic Review. 
  • Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy. 
  • The measurement of free erythrocyte porphyrin (FEP) as a simple means of distinguishing iron deficiency from beta-thalassemia trait in subjects with microcytosis. 
  • The nature of aqueous tunneling pathways between electron-transfer proteins. 
  • Thiol regulation by Mn porphyrins, commonly known as SOD mimics. 
  • Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential. 
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  Keywords of People

  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology