Precancerous Conditions

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  Subject Areas on Research

  • (18)F-Flourodeoxy-Glucose PET/Computed Tomography in Brain Tumors: Value to Patient Management and Survival Outcomes. 
  • 5-Fluorouracil for Actinic Keratosis Treatment and Chemoprevention: A Randomized Controlled Trial. 
  • A Polyp Worth Removing: A Paradigm for Measuring Colonoscopy Quality and Performance of Novel Technologies for Polyp Detection. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A primer of endometrial cytology with histological correlation. 
  • A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patient. 
  • Abnormal Fhit expression in malignant and premalignant lesions of the cervix. 
  • Accuracy of visual inspection with acetic acid to detect cervical cancer precursors among HIV-infected women in Kenya. 
  • Addressing overdiagnosis and overtreatment in cancer: a prescription for change. 
  • Adenosis and clear-cell carcinoma of the vagina. An invitational sympotium. Introduction. 
  • Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent. 
  • Altered expression of transforming growth factor-alpha: an early event in renal cell carcinoma development. 
  • Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro. 
  • Angle-resolved low coherence interferometry for detection of dysplasia in Barrett's esophagus. 
  • Association of Helicobacter pylori and Autoimmune Gastritis With Stomach Cancer in a Cohort of Young Finnish Women. 
  • Atypical ductal hyperplasia: improved accuracy with the 11-gauge vacuum-assisted versus the 14-gauge core biopsy needle. 
  • Basal cell carcinoma originating from a nevus sebaceus on the scalp of a 7-year-old boy. 
  • Basic population and cancer genetics and their use in the assessment of cancer risk. 
  • Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. 
  • Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma. 
  • Cancer Progress and Priorities: Gastric Cancer. 
  • Cholangiocarcinoma arising from intraductal papillary mucinous neoplasm of the bile duct. 
  • Circulating Leptin and Branched Chain Amino Acids-Correlation with Intraductal Papillary Mucinous Neoplasm Dysplastic Grade. 
  • Circumferential ablation of Barrett's esophagus that contains high-grade dysplasia: a U.S. Multicenter Registry. 
  • Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. 
  • Colorectal cancer surveillance in inflammatory bowel disease: Practice guidelines and recent developments. 
  • Consensus report from the 7th International Forum for Liver Magnetic Resonance Imaging. 
  • Controlling Gastric Cancer in a World of Heterogeneous Risk. 
  • Cytological evaluation correlates poorly with histological diagnosis of vulvar neoplasias. 
  • Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations. 
  • Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy. 
  • Development of Algorithms for Automated Detection of Cervical Pre-Cancers With a Low-Cost, Point-of-Care, Pocket Colposcope. 
  • Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis. 
  • Differential immunoreactivity of transforming growth factor alpha in benign, dysplastic and malignant prostatic tissues. 
  • Differentiation of pancreatic ductal adenocarcinoma from chronic pancreatitis by PAM4 immunohistochemistry. 
  • Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Imaging and Clinical Features of a Frequently Delayed Diagnosis. 
  • Dose dependence of mass and microcalcification detection in digital mammography: free response human observer studies. 
  • Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. 
  • Early onset of spontaneous renal preneoplastic and neoplastic lesions in young conventional rats in toxicity studies. 
  • Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. 
  • Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus. 
  • Estimating the costs of HIV clinic integrated versus non-integrated treatment of pre-cancerous cervical lesions and costs of cervical cancer treatment in Kenya. 
  • Estrogen treatment enhances hereditary renal tumor development in Eker rats. 
  • Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression. 
  • Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett's esophagus. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • External ocular pigmentation. 
  • FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. 
  • Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. 
  • Genetic alterations in prostate adenocarcinoma. 
  • Genetic testing and tumor surveillance for children with cancer predisposition syndromes. 
  • Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. 
  • Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? 
  • High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. 
  • Hit or a miss: Concordance between histopathologic-endoscopic findings in gastric mucosal biopsies. 
  • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. 
  • Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. 
  • Immunohistochemical expression of p16 and Ki-67 correlates with degree of anal intraepithelial neoplasia. 
  • Immunostimulatory membrane proteins potentiate H. pylori-induced carcinogenesis by enabling CagA translocation. 
  • Incidence and clinical significance of morphologically benign-appearing endometrial cells in patients age 40 years or older: the impact of the 2001 Bethesda System. 
  • Incidental minimal atypical lobular hyperplasia on core needle biopsy: correlation with findings on follow-up excision. 
  • Increased ubiquitin immunoreactivity in hepatocellular carcinomas and precancerous lesions of the liver. 
  • Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E. 
  • Influence of smoking history on imaging characteristics among patients with human papillomavirus-positive oropharyngeal cancer: a blinded matched-pair analysis. 
  • Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers. 
  • Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection. 
  • Is Excisional Biopsy Needed for Pure FEA Diagnosed on a Core Biopsy? 
  • Is colorectal cancer surveillance cost-effective in patients with ulcerative colitis? 
  • Keratinocyte growth regulation TRP-ed up over downregulated TRPV4? 
  • Laser-induced fluorescence spectroscopy: somewhere over the rainbow. 
  • Liberal resection for (presumed) Sendai negative branch-duct intraductal papillary mucinous neoplasms--also not harmless. 
  • Lichen sclerosus: review of the literature and current recommendations for management. 
  • Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice. 
  • Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. 
  • Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein. 
  • Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. 
  • Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. 
  • Molecular genetics of premalignant oral lesions. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. 
  • Nuclear morphology measurements with angle-resolved low coherence interferometry for application to cell biology and early cancer detection. 
  • Optical imaging of cervical pre-cancers with structured illumination: an integrated approach. 
  • Optimal visual perception and detection of oral cavity neoplasia. 
  • Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus. 
  • Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. 
  • Overutilization of endoscopic surveillance in nondysplastic Barrett's esophagus: a multicenter study. 
  • PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts. 
  • Pathology of vaginal and cervical abnormalities associated with prenatal exposure to diethylstilbestrol (des). 
  • Precancerous lesions of the digestive tract. The 18th Annual Symposium of the European Cancer Prevention Organization. Maastricht, The Netherlands. 12-14 October 2000. Abstracts. 
  • Pregnancy after treatment for cervical cancer precursor lesions in a retrospective matched cohort. 
  • Premalignant and malignant cells in sputum from lung cancer patients. 
  • Premalignant cystic neoplasms of the pancreas. 
  • Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 
  • Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. 
  • Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. 
  • Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma. 
  • Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats. 
  • Quantifying the Dynamics of Field Cancerization in Tobacco-Related Head and Neck Cancer: A Multiscale Modeling Approach. 
  • Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues. 
  • Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy. 
  • Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. 
  • Reflectance spectroscopy. 
  • Reliable methods to evaluate the burden of actinic keratoses. 
  • Renal epithelial dysplasia. 
  • Reproducibility and variability of the rectal mucosal proliferation index using proliferating cell nuclear antigen immunohistochemistry. 
  • Risk factors for cervical precancer detection among previously unscreened HIV-infected women in Western Kenya. 
  • Screening, prevalence, and risk factors for cervical lesions among HIV positive and HIV negative women in Swaziland. 
  • Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung. 
  • Should Patients With Cystic Lesions of the Pancreas Undergo Long-term Radiographic Surveillance?: Results of 3024 Patients Evaluated at a Single Institution. 
  • Small-bowel malabsorption and gastrointestinal malignancy. 
  • Spatial Measures of Genetic Heterogeneity During Carcinogenesis. 
  • Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. 
  • Systemic markers of oxidative status and colorectal adenomatous polyps. 
  • TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions. 
  • The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions. 
  • The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions. 
  • The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. 
  • The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. 
  • The effects of local progesterone on stilbestrol-associated vaginal adenosis. 
  • The significance of adenosis and clear-cell adenocarcinoma of the genital tract in young females. 
  • The significance of the diagnosis of atypia in breast fine-needle aspiration. 
  • Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. 
  • Towards a more accurate assessment of the malignant potential in conjunctival melanosis. 
  • Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study. 
  • Workshop on imaging science development for cancer prevention and preemption. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering