Pregnanolone
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Subject Areas on Research
- A randomized controlled trial of ganaxolone in posttraumatic stress disorder.
- A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.
- Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.
- Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture.
- Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
- Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.
- Brexanolone as adjunctive therapy in super-refractory status epilepticus.
- DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
- Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.
- Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
- Neuroactive steroids and PTSD treatment.
- Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
- Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.
- Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.
- Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.
- Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
- Olanzapine increases allopregnanolone in the rat cerebral cortex.
- PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.
- Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
- The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
- The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.
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Keywords of People
- Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
- Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology