Pregnanolone

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  Subject Areas on Research

  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder. 
  • A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. 
  • Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits. 
  • Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects. 
  • Brexanolone as adjunctive therapy in super-refractory status epilepticus. 
  • DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. 
  • Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Neuroactive steroids and PTSD treatment. 
  • Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. 
  • Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. 
  • Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001. 
  • Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents. 
  • Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. 
  • Olanzapine increases allopregnanolone in the rat cerebral cortex. 
  • PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma. 
  • Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. 
  • The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease. 
  • The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity. 
  • The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback. 
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  Keywords of People

  • Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology