Pregnenolone
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Subject Areas on Research
- A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.
- Adrenal physiology and pharmacology.
- Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
- Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury
- Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.
- Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
- DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
- Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.
- Metabolites of progesterone in urine compared with progesterone in ovarian venous plasma of the cycling domestic sow.
- Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
- Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
- Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
- Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.
- Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.
- Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?
- Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia.
- Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
- Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum.
- The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
- The steroid profile of a virilizing ovarian tumor.
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Keywords of People
- Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
- Schwartz-Bloom, Rochelle D., Professor in Pharmacology & Cancer Biology, Duke Science & Society