Pregnenolone

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  Subject Areas on Research

  • A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. 
  • Adrenal physiology and pharmacology. 
  • Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits. 
  • Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats. 
  • Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage. 
  • Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy? 
  • DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. 
  • Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial. 
  • Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder. 
  • Metabolites of progesterone in urine compared with progesterone in ovarian venous plasma of the cycling domestic sow. 
  • Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. 
  • Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. 
  • Neurosteroid transport by the organic solute transporter OSTα-OSTβ. 
  • Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. 
  • Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. 
  • Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice. 
  • Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? 
  • Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia. 
  • Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. 
  • Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum. 
  • The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease. 
  • The steroid profile of a virilizing ovarian tumor. 
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  Keywords of People

  • Bradford, Daniel William, Professor of Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society