Progesterone

• 

  Subject Areas on Research

  • 6-Methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity. 
  • A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. 
  • A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. 
  • A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells. 
  • A transformation approach for incorporating monotone or unimodal constraints. 
  • Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats. 
  • Absence of teratogenic effects of progesterone on the developing genital tract of the human female fetus. 
  • Actions of steroids in mitochondria. 
  • Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 2. 
  • Acute effects of cocaine on ornithine decarboxylase activity in fetal and neonatal rat heart: evidence for cardiotoxicity. 
  • Adrenomedullin expression in rat uterus is correlated with plasma estradiol. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Alterations in luteal phase progesterone and estradiol production after leuprolide acetate therapy before ovarian stimulation for in vitro fertilization. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Assessing human fertility using several markers of ovulation. 
  • Assessment of sex steroid action in vitro. 
  • Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes. 
  • Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition. 
  • Bayesian adaptive regression splines for hierarchical data. 
  • Binding of progesterone to cell surfaces of human granulosa-lutein cells. 
  • Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease. 
  • Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium. 
  • Clinical characteristics of ovulation induction with human menopausal gonadotropins with and without leuprolide acetate in polycystic ovary syndrome. 
  • Coming of age: steroid hormones of wild immature baboons (Papio cynocephalus). 
  • Comparison of prostaglandin F2alpha and hypertonic saline for induction of midtrimester abortion. 
  • Compartmental ovarian steroidogenesis in polycystic ovary syndrome. 
  • Conditional estimation for generalized linear models when covariates are subject-specific parameters in a mixed model for longitudinal measurements. 
  • Continuous extraovular administration of prostaglandin F2alpha for midtrimester abortion. 
  • Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin. 
  • Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles. 
  • Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. 
  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. 
  • Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. 
  • Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study. 
  • Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the ACTG 5283 study. 
  • Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Dietary galactose inhibits GDF-9 mediated follicular development in the rat ovary. 
  • Does progesterone supplementation improve pregnancy rates in clomiphene citrate and intrauterine insemination treatment cycles? 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • EFFECTS OF 6 ALPHA-METHYL-17-ACETOXYPROGESTERONE, 17 ALPHA-ETHYNYL-19-NORTESTOSTERONE, PROGESTERONE, AND TESTOSTERONE PROPIONATE ON THE ADRENALS, GONADS, AND BURSA OF FABRICIUS OF THE CHICKEN. 
  • Early follicular rise of serum progesterone concentration in response to a flare-up effect of gonadotrophin-releasing hormone agonist impairs follicular recruitment for in-vitro fertilization. 
  • Early pregnancy interruption with two 15-ME-PGF2a suppositories. 
  • Effect of an intrauterine contraceptive device on uterine motility in the rat. 
  • Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine. 
  • Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro. 
  • Effects of bovine luteinizing hormone and human chorionic gonadotrophin on the bovine corpus luteum in vivo. 
  • Effects of fat supplementation and immature alfalfa to concentrate ratio on plasma progesterone, energy balance and reproductive traits of dairy cattle. 
  • Effects of intranasal administration of norethisterone on folliculogenesis, cervical mucus, vaginal cytology, endometrial morphology and reproductive-endocrine profile in women. 
  • Effects of menstrual cycle and urinary tract instrumentation on uroflowmetry. 
  • Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C). 
  • Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. 
  • Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. 
  • Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system. 
  • Endometrial hyperplasia risk in relation to recent use of oral contraceptives and hormone therapy. 
  • Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates. 
  • Estrogen and progesterone production by developing porcine follicles in vitro: evidence for estrogen formation by theca. 
  • Estrogen and progesterone production by granulosa cell monolayers derived from in vitro fertilization procedures: lack of evidence for modulation by androgen. 
  • Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. 
  • Evaluation of danazol as an oral contraceptive. 
  • Female steroid hormones and lipoprotein synthesis in the cockerel: effects of progesterone and nafoxidine on the estrogenic stimulation of very low density lipoproteins (VLDL) synthesis. 
  • Female steroid hormones and target cell nuclei. 
  • Follicle-stimulating hormone-mediated induction of functional luteinizing hormone/human chorionic gonadotropin receptors during monolayer culture of porcine granulosa cells. 
  • Follicular atresia associated with concurrent initiation of gonadotropin-releasing hormone agonist and follicle-stimulating hormone for oocyte recruitment. 
  • Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase. 
  • Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity. 
  • Hepatic focal nodular hyperplasia in infant antenatally exposed to steroids. 
  • Hepatic prolactin binding in female Sprague-Dawley rats fed a diet high in corn oil. 
  • Hereditary angioedema. 
  • Hereditary angioedema: the clinical syndrome and its management. 
  • Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor. 
  • High level expression of a truncated chicken progesterone receptor in Escherichia coli. 
  • Hormonal characteristics of free-ranging female lions (Panthera leo) of the Serengeti Plains and Ngorongoro Crater. 
  • Hormonal consequences of "missing the pill". 
  • Hormonal modulation of the cutaneous initiation of lordosis in infant and adult rats. 
  • Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase. 
  • Hormone therapy: physiological complexity belies therapeutic simplicity. 
  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. 
  • How can we better predict the risk of spontaneous miscarriage among women experiencing threatened miscarriage? 
  • Human placental lactogen infusions into the medial preoptic area stimulate maternal behavior in steroid-primed, nulliparous female rats. 
  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. 
  • Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells. 
  • Hyperprogesteronemia in response to Vitex fischeri consumption in wild chimpanzees (Pan troglodytes schweinfurthii). 
  • Identification of metabolities of progesterone-4-14C in domestic sow urine. 
  • Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults. 
  • Implantation and pregnancy rates in relation to oestradiol and progesterone profiles in cycles with and without the use of gonadotrophin-releasing hormone agonist suppression. 
  • In vitro fertilization and embryo transfer (IVF/ET): an established and successful therapy for endometriosis. 
  • Inability of gestational hormones to account for the inhibitory effects of pregnancy plasmas on lymphocyte responses in vitro. 
  • Incidence and biomarkers of pregnancy, spontaneous abortion, and neonatal loss during an environmental stressor: Implications for female reproductive suppression in the cooperatively breeding meerkat. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Induction of specific translatable messenger RNA's by oestrogen and progesterone. 
  • Influence of number of pre-embryos transferred, progesterone level and oestradiol/progesterone ratio at thaw on pregnancy results during replacement of cryopreserved pre-embryos in natural cycles. 
  • Influence of vitamin A injection before mating on oocyte development, follicular hormones, and ovulation in gilts fed high-energy diets. 
  • Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. 
  • Interactions between hormones and growth factors in the regulation of granulosa cell differentiation in vitro. 
  • Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age. 
  • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. 
  • Luteal phase serum estradiol and progesterone in in vitro fertilization. 
  • Luteal supplementation in in vitro fertilization: more questions than answers. 
  • Luteal support with both estradiol and progesterone after clomiphene citrate stimulation for in vitro fertilization. 
  • Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy. 
  • Management of Short Cervix during Pregnancy: A Review. 
  • Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. 
  • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. 
  • Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs). 
  • Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. 
  • Memory retention is modulated by acute estradiol and progesterone replacement. 
  • Menstrual cycle effects on caffeine elimination in the human female. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Metabolites of progesterone in urine compared with progesterone in ovarian venous plasma of the cycling domestic sow. 
  • Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes. 
  • Midtrimester abortion induced with a single intra-amniotic instillation of prostaglandin F2 alpha. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. 
  • Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. 
  • Monolayer growth and differentiated function of porcine and rat granulosa cells following cryopreservation. 
  • Neuromuscular and biomechanical characteristics do not vary across the menstrual cycle. 
  • Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents. 
  • Olanzapine increases allopregnanolone in the rat cerebral cortex. 
  • Oocyte donation. The Norfolk Program. 
  • Ovarian effects of a high lactose diet in the female rat. 
  • PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma. 
  • Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures. 
  • Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program. 
  • Predictive value of progesterone and estradiol levels for pregnancy. 
  • Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone. 
  • Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. 
  • Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage. 
  • Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model. 
  • Progesterone inhibits glucocorticoid-induced murine thymocyte apoptosis. 
  • Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. 
  • Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome. 
  • Progesterone levels on the day of human chorionic gonadotropin do not predict pregnancy outcome from the transfer of fresh or cryopreserved embryos from the same cohort. 
  • Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death. 
  • Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells. 
  • Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone. 
  • Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology. 
  • RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. 
  • Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. 
  • Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. 
  • Refinement of a protocol for the induction of lactation in nonpregnant nonhuman primates by using exogenous hormone treatment. 
  • Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. 
  • Regulation of the prostaglandin enzymatic system by estradiol and progesterone in nonpregnant sheep cervix. 
  • Relation of results of exercise stress tests in young women to phases of the menstrual cycle. 
  • Responses to olfactory stimuli in spotted hyenas (Crocuta crocuta): II. Discrimination of conspecific scent. 
  • Results of in vitro fertilization attempts in patients with one or two ovaries. 
  • Risk factors for cancer of the testis. 
  • Screening of potential reproductive toxicants by use of porcine granulosa cell cultures. 
  • Serum progesterone for the exclusion of early pregnancy in women at risk for recurrent gestational trophoblastic neoplasia. 
  • Serum progesterone levels following vaginal administration of progesterone during the luteal phase. 
  • Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. 
  • Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum. 
  • Simultaneous quantitation of multiple contraceptive hormones in human serum by LC-MS/MS. 
  • Some social and hormonal determinants of nest-building behaviour in the ring dove (Streptopelia risoria). 
  • Spatial memory retention is enhanced by acute and continuous estradiol replacement. 
  • Spontaneous pregnancy reaches viability after low first trimester serum progesterone: a case report. 
  • Statistical scuds. 
  • Steroid hormone induction of a specific translatable messenger RNA. 
  • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. 
  • Steroid hormone regulation of specific gene expression. 
  • Steroid hormone regulation of specific messenger RNA and protein synthesis in eucaryotic cells. 
  • Steroid hormones drive cancer development. 
  • Steroidal modulation of progesterone secretion by granulosa cells from large porcine follicles: a role for androgens and estrogens in controlling steroidogenesis. 
  • Steroidal modulation of steroid secretion in vitro: an experimental approach to intra-follicular regulatory mechanisms. 
  • Steroidogenesis in porcine atretic follicles: loss of aromatase activity in isolated granulosa and theca. 
  • Stress affects uterine receptivity through an ovarian-independent pathway. 
  • Sufficient progesterone-priming prior to estradiol stimulation is required for optimal induction of the cervical prostaglandin system in pregnant sheep at 0.7 gestations. 
  • Synergistic effect of insulin and follicle-stimulating hormone on biochemical and morphological differentiation of porcine granulosa cells in vitro. 
  • Synthetic estrogens suppress granulosa cell progesterone production in vitro. 
  • TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro. 
  • The Effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women. 
  • The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection. 
  • The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action. 
  • The anti-androgen combination, flutamide plus finasteride, paradoxically suppressed LH and androgen concentrations in pregnant spotted hyenas, but not in males. 
  • The antibiotic azatyrosine suppresses progesterone or [Val12]p21 Ha-ras/insulin-like growth factor I-induced germinal vesicle breakdown and tyrosine phosphorylation of Xenopus mitogen-activated protein kinase in oocytes. 
  • The combination of follicle-stimulating hormone and human menopausal gonadotropin for the induction of multiple follicular maturation for in vitro fertilization. 
  • The effect of leuprolide acetate on ovulation induction with human menopausal gonadotropins in polycystic ovary syndrome. 
  • The effect of plating density on granulosa cell growth and differentiation in vitro. 
  • The effect of transforming growth factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. 
  • The effects of local progesterone on stilbestrol-associated vaginal adenosis. 
  • The luteal phase in polycystic ovary syndrome during ovulation induction with human menopausal gonadotropin with and without leuprolide acetate. 
  • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. 
  • The mechanism of steroid-hormone regulation of transcription of specific eukaryotic genes. 
  • The molecular pharmacology of ovarian steroid receptors. 
  • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. 
  • The prediction and/or detection of ovulation by means of urinary steroid assays. 
  • The prognostic value of serum concentrations of progesterone, estradiol, and luteinizing hormone during superovulation with and without adjunctive leuprolide therapy. 
  • The psychobiology of premenstrual dysphoria: review of theories and treatments. 
  • The psychobiology of premenstrual dysphoria: the role of prolactin. 
  • The randomised controlled trial of micronised progesterone and dydrogesterone (TRoMaD) for threatened miscarriage. 
  • The relationship of ovarian steroids, headache activity and menstrual distress: a pilot study with female migraineurs. 
  • The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback. 
  • The timing of the "fertile window" in the menstrual cycle: day specific estimates from a prospective study. 
  • The use of a urinary estrone conjugates assay for detection of optimal mating time in the cynomolgus macaque (Macaca fascicularis). 
  • The utility of menstrual cycle length as an indicator of cumulative hormonal exposure. 
  • The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. 
  • Transdermal progesterone cream as an alternative progestin in hormone therapy. 
  • Transfer of cryopreserved-thawed pre-embryos in a cycle using exogenous steroids without prior gonadotrophin-releasing hormone agonist suppression yields favourable pregnancy results. 
  • Tyrosine hydroxylase mRNA in the neurons of the tuberoinfundibular region and zona incerta examined after gonadal steroid hormone treatment. 
  • Urinary 6-hydroxymelatonin in menstruating women. 
  • Use of hMG and/or FSH for multiple follicle development. 
  • Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage. 
  • Vasomotor symptoms, serum estrogens, and gonadotropin levels in surgical menopause. 
  • Women recovering from social rejection: The effect of the person and the situation on a hormonal mechanism of affiliation. 
  • hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology