Proline

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  Subject Areas on Research

  • A Pragmatic, Randomized Controlled Trial of Oral Antivirals for the Treatment of Chronic Hepatitis C: The PRIORITIZE Study. 
  • A cooperative multicenter study of captopril in congestive heart failure: hemodynamic effects and long-term response. 
  • A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. 
  • A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter. 
  • A novel rhodopsin point mutation, proline-170-histidine, associated with sectoral retinitis pigmentosa. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules. 
  • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. 
  • Amino acid preferences for specific locations at the ends of alpha helices. 
  • Amino acid uptake by isolated renal brush border membrane vesicles in various buffers. 
  • Antisense oligonucleotide therapy for proline-23-histidine autosomal dominant retinitis pigmentosa. 
  • Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. 
  • Autoradiographic localization of proline uptake in excitatory hippocampal pathways. 
  • Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. 
  • Boceprevir for HCV in patients with HIV: where next? 
  • Boceprevir for chronic HCV genotype 1 infection in patients with prior treatment failure to peginterferon/ribavirin, including prior null response. 
  • Boceprevir for untreated chronic HCV genotype 1 infection. 
  • Capillary electrophoresis with solid-state electrochemiluminescence detector. 
  • Captopril and renal insufficiency. 
  • Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. 
  • Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. 
  • Characterization of prolidase activity using capillary electrophoresis with tris(2,2'-bipyridyl)ruthenium(II) electrochemiluminescence detection and application to evaluate collagen degradation in diabetes mellitus. 
  • Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. 
  • Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. 
  • Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity. 
  • Economic evaluation of direct-acting antiviral therapy in chronic hepatitis C. 
  • Effect of cystine loading and cystine dimethylester on renal brushborder membrane transport. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep. 
  • Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis). 
  • Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial. 
  • Eight Weeks of Treatment With Glecaprevir/Pibrentasvir Is Safe and Efficacious in an Integrated Analysis of Treatment-Naïve Patients With Hepatitis C Virus Infection. 
  • Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • IL28B in the era of direct-acting antivirals for hepatitis C. 
  • Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. 
  • Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome. 
  • Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • Intrinsically disordered proteins access a range of hysteretic phase separation behaviors. 
  • Is the HCV pipeline heading in the right direction? 
  • Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. 
  • Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. 
  • Methodological remarks concerning the recent meta-analysis on p53 codon 72 polymorphism and colorectal cancer risk. 
  • Microchip capillary electrophoresis with solid-state electrochemiluminescence detector. 
  • Microfluidic chip with electrochemiluminescence detection using 2-(2-aminoethyl)-1-methylpyrrolidine labeling. 
  • Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein. 
  • NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells. 
  • New Treatment Options for Hepatitis C Virus Infection in End-Stage Kidney Disease: To Treat or Not to Treat. 
  • Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. 
  • P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population. 
  • Patient-reported symptoms during and after direct-acting antiviral therapies for chronic hepatitis C: The PROP UP study. 
  • Physiological responses of Norway spruce (Picea abies) seedlings to drought stress. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Prediction of treatment week eight response & sustained virologic response in patients treated with boceprevir plus peginterferon alfa and ribavirin. 
  • Preorganized secondary structure as an important determinant of fast protein folding. 
  • Preservation of brush border transport systems for proline and alpha-methyl-D glucoside from rat, dog, and human kidney. 
  • Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. 
  • Proline-induced inhibition of glutamate release in hippocampal area CA1. 
  • Proline-induced potentiation of glutamate transmission. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. 
  • Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. 
  • SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation. 
  • Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET. 
  • Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial. 
  • Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. 
  • Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development. 
  • Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells. 
  • Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. 
  • Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain. 
  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation. 
  • Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure. 
  • Telaprevir for the treatment of chronic hepatitis C infection. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • The Ca, Pi, F, and proline content of developing bovine enamel under GBHA-stained and unstained bands. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The crystal structure of the collagen-like polypeptide (glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyprolyl)9 at 1.55 A resolution shows up-puckering of the proline ring in the Xaa position. 
  • The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The use of proline as a nitrogen source causes hypersensitivity to, and allows more economical use of 5FOA in Saccharomyces cerevisiae. 
  • Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Toxicity of L-proline toward rat hippocampal neurons. 
  • Treatment patterns, health care resource utilization, and costs in U.S. patients diagnosed with chronic hepatitis C infection who received telaprevir or boceprevir. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Uptake of proline by brushborder vesicles isolated from human kidney cortex. 
  • Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology