Promoter Regions, Genetic
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Subject Areas on Research
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14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1.
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172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
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27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
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A 13-kilodalton maize mitochondrial protein in E. coli confers sensitivity to Bipolaris maydis toxin.
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A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.
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A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter.
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A Bayesian network approach to operon prediction.
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A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
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A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.
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A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
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A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression.
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A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1.
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A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.
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A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
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A cis-acting sequence homologous to the yeast filamentation and invasion response element regulates expression of a pectinase gene from the bean pathogen Colletotrichum lindemuthianum.
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A cis-regulatory map of the Drosophila genome.
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A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection.
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A combinatorial mechanism for determining the specificity of E2F activation and repression.
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A compendium of promoter-centered long-range chromatin interactions in the human genome.
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A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
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A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity.
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A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2).
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A conserved domain of the viviparous-1 gene product enhances the DNA binding activity of the bZIP protein EmBP-1 and other transcription factors.
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A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
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A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
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A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.
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A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.
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A functional antigenomic promoter for the paramyxovirus simian virus 5 requires proper spacing between an essential internal segment and the 3' terminus.
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A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.
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A functional prodynorphin promoter polymorphism and opioid dependence.
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A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis.
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A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.
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A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
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A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.
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A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
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A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function.
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A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation.
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A lentiviral vector bearing a reverse intron demonstrates superior expression of both proteins and microRNAs.
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A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
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A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.
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A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity.
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A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.
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A novel 2-oxoacid-dependent dioxygenase involved in the formation of the goiterogenic 2-hydroxybut-3-enyl glucosinolate and generalist insect resistance in Arabidopsis,.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
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A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer.
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A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer.
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A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.
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A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.
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A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.
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A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.
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A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.
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A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
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A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
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A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.
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A paired-end sequencing strategy to map the complex landscape of transcription initiation.
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A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas.
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A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.
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A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint.
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A potential role for Elf-1 in CD4 promoter function.
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A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast.
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A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking.
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A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.
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A promoter sequence variant of ZNF750 is linked with familial psoriasis.
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A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells.
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A rapid and simple quantitative method for specific detection of smaller coterminal RNA by PCR (DeSCo-PCR): application to the detection of viral subgenomic RNAs.
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A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability.
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A small regulatory element from chromosome 19 enhances liver-specific gene expression.
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A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.
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A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.
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A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
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A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.
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A transcription factor affinity-based code for mammalian transcription initiation.
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A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.
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A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.
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A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters.
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A20 modulates lipid metabolism and energy production to promote liver regeneration.
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ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors.
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ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.
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APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.
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ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
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Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
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Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.
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Activation and repression of mammalian gene expression by the c-myc protein.
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Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
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Activation of the heat shock transcription factor by hypoxia in mammalian cells.
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Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1.
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Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements.
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Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes.
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Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.
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Airway-specific inducible transgene expression using aerosolized doxycycline.
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Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.
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Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution.
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Alteration of Caenorhabditis elegans gene expression by targeted transformation.
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Alternative Splicing of Rice WRKY62 and WRKY76 Transcription Factor Genes in Pathogen Defense.
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Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect.
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An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients.
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An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects.
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An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
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An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents.
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An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants.
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An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
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An integrated encyclopedia of DNA elements in the human genome.
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An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
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An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau.
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Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract.
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Analysis of CpG methylation in the killifish CYP1A promoter.
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Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots.
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Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors.
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Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.
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Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.
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Ancient and recent positive selection transformed opioid cis-regulation in humans.
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Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.
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Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway.
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AnkyrinG is required to maintain axo-dendritic polarity in vivo.
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Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.
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Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.
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Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.
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Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield.
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Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells.
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Architecture and inherent robustness of a bacterial cell-cycle control system.
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Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Assessing transcription factor motif drift from noisy decoy sequences.
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Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.
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Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients.
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Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta-analysis.
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Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
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Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.
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Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
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Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.
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Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.
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Association of heat shock proteins with all-cause mortality.
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Association of increased spontaneous mutation rates with high levels of transcription in yeast.
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Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking.
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Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma.
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Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.
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Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
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BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.
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Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors.
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Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction.
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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
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Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
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Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.
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Binding site graphs: a new graph theoretical framework for prediction of transcription factor binding sites.
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Bioelectronic measurement and feedback control of molecules in living cells.
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Biological functions of activity-dependent transcription revealed.
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Bleomycin induces the hsp 70 heat shock promoter in cultured cells.
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Broad host range vectors for stable genomic library construction.
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CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.
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CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis.
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CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
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CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables.
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CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.
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CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.
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Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs.
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Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms.
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Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.
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Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
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Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
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Carbonyl-metabolizing enzymes and their relatives recruited as structural proteins in the eye lens.
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Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.
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Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
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Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity.
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Cell identity mediates the response of Arabidopsis roots to abiotic stress.
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Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
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Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.
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Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.
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Central nervous system serotonin function and cardiovascular responses to stress.
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Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase.
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Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1.
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Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin.
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Characterization of a putative periplasmic transport system for octopine accumulation encoded by Agrobacterium tumefaciens Ti plasmid pTiA6.
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Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.
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Characterization of cis-regulatory regions responsible for developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.
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Characterization of murine carcinoembryonic antigen gene family members.
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Characterization of the PC4 binding domain and its interactions with HNF4alpha.
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Characterization of the cell death promoter, Bad, in the developing rat retina and forebrain.
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Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
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Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.
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Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.
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Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia.
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Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity.
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Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein.
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Chicken calmodulin promoter activity in proliferating and differentiated cells.
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Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.
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Chromatin architecture reorganization during stem cell differentiation.
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Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.
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Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease.
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CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.
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Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis.
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Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice.
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Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
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Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X.
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
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Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region.
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Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1.
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Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis.
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Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
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Coactivator AIB1 links estrogen receptor transcriptional activity and stability.
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Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene.
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Combined p53-related genetic variants together with HPV infection increase oral cancer risk.
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Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST.
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Common promoter elements in odorant and vomeronasal receptor genes.
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Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee.
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Comparative analysis of metazoan chromatin organization.
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Comparative genomics and regulatory evolution: conservation and function of the Chs and Apetala3 promoters.
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Comparison of human and Xenopus GATA-2 promoters.
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Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.
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Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements.
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Complex relationship between Parkin mutations and Parkinson disease.
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Complex structure and regulation of the ABP/SHBG gene.
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Compromised HOXA5 function can limit p53 expression in human breast tumours.
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Computational analysis of core promoters in the Drosophila genome.
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Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.
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Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation.
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Consistent production of transgenic chickens using replication-deficient retroviral vectors and high-throughput screening procedures.
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Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.
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Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity.
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Control of CD4 gene expression: connecting signals to outcomes in T cell development.
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Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
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Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit.
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Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.
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Conversion of compatible plant-pathogen interactions into incompatible interactions by expression of the Pseudomonas syringae pv. syringae 61 hrmA gene in transgenic tobacco plants.
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Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
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Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
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Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.
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Coordinated genome-wide modifications within proximal promoter cis-regulatory elements during vertebrate evolution.
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Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter.
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Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy.
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Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment.
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Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
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Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
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Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.
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Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.
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Cryptococcus neoformans virulence gene discovery through insertional mutagenesis.
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Crystal structure of MtaN, a global multidrug transporter gene activator.
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Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
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Crystal structure of the transcription activator BmrR bound to DNA and a drug.
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Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
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Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
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Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes.
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Cytokine polymorphism and its possible impact on cancer.
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Cytokine transcriptional events during helper T cell subset differentiation.
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Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.
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Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.
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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.
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DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.
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DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes.
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DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.
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DNA repair proteins are directly involved in regulation of gene expression during plant immune response.
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DNA replication and transcription programs respond to the same chromatin cues.
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DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis.
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DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
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DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells.
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Daughter-specific transcription factors regulate cell size control in budding yeast.
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Decoding the role of regulatory element polymorphisms in complex disease.
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Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
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Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
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Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions.
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Deletion analysis of bacteriophage T4 tertiary origins. A promoter sequence is required for a rifampicin-resistant replication origin.
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Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.
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Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
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Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1.
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Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors.
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Detection of broadly expressed neuronal genes in C. elegans.
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Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio).
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Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine.
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Developmental regulation of DNA replication: replication fork barriers and programmed gene amplification in Tetrahymena thermophila.
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Developmental regulation of mouse SPARC (osteonectin) gene expression.
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Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.
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Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast.
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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.
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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
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Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
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Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
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Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal.
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Differential regulation of genes by retrotransposons in rice promoters.
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Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
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Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
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Discovering sequences with potential regulatory characteristics.
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Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
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Dissecting the regulatory architecture of gene expression QTLs.
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Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs.
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Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver.
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Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter.
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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
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Distinct functional programming of human fetal and adult monocytes.
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Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.
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Distinct properties of cell-type-specific and shared transcription factor binding sites.
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Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.
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Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination.
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Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis.
-
Does HIV-1 Tat induce a change in viral initiation rights?
-
Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells.
-
Dominant selection system for use in Cryptococcus neoformans.
-
Downregulation of RNA polymerase III transcription of the hY3 gene in vitro.
-
Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.
-
Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.
-
Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters.
-
Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family.
-
Dynamic DNA methylation across diverse human cell lines and tissues.
-
Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
-
E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx.
-
E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
-
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
-
ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months tamoxifen chemoprevention.
-
Early nurture epigenetically tunes the oxytocin receptor.
-
Ecdysone-inducible gene expression in mammalian cells and transgenic mice.
-
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.
-
Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.
-
Effects of 5HTTLPR on cardiovascular response to an emotional stressor.
-
Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.
-
Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression.
-
Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors.
-
Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes.
-
Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction.
-
Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.
-
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
-
Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.
-
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.
-
Endogenous protein S-Nitrosylation in E. coli: regulation by OxyR.
-
Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells.
-
Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.
-
Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages.
-
Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice.
-
Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
-
Engineering key components in a synthetic eukaryotic signal transduction pathway.
-
Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection.
-
Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.
-
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
-
Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution.
-
Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.
-
Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
-
Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.
-
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
-
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
-
Epigenetic and epitranscriptomic regulation of viral replication.
-
Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders.
-
Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers.
-
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
-
Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.
-
Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma.
-
Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation.
-
Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.
-
Erythroid AP-1/NF-E2 elements vary in their response to NF-E2.
-
Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors.
-
Estrogen and thyroid hormone interaction on regulation of gene expression.
-
Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.
-
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.
-
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.
-
Evaluating and enhancing ribozyme reaction efficiency in mammalian cells.
-
Evaluation of a recombinant yeast cell estrogen screening assay.
-
Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.
-
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.
-
Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene.
-
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
-
Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites.
-
Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay.
-
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
-
Explicit equilibrium modeling of transcription-factor binding and gene regulation.
-
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.
-
Exploring motif composition of eukaryotic promoter regions.
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
-
Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.
-
Expression and function of the uvsW gene of bacteriophage T4.
-
Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis.
-
Expression of CRISPR/Cas single guide RNAs using small tRNA promoters.
-
Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR.
-
Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).
-
Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.
-
Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.
-
Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.
-
Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta.
-
Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells.
-
Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma.
-
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
-
Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
-
Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.
-
Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.
-
Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target.
-
Finding regulatory DNA motifs using alignment-free evolutionary conservation information.
-
First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum.
-
Fluorescence-based isolation of bacterial genes expressed within host cells.
-
Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.
-
Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.
-
Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results.
-
Formation of a rate-limiting intermediate in 5S RNA gene transcription.
-
FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
-
Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition.
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
-
From man to fish: What can Zebrafish tell us about ApoL1 nephropathy?
-
Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice.
-
Functional analysis of the transcription control region located within the avian retroviral long terminal repeat.
-
Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.
-
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
-
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.
-
Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro.
-
Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.
-
Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.
-
Functional human renin promoter in transfected cells: evidence for cell-specific expression.
-
Functional organization of the Bel-1 trans activator of human foamy virus.
-
Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients.
-
Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans.
-
Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.
-
Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.
-
Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.
-
Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.
-
GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription.
-
GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration.
-
GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.
-
GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila.
-
GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis.
-
Gamma-globin gene promoter elements required for interaction with globin enhancers.
-
Gateway-compatible tissue-specific vectors for plant transformation.
-
Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.
-
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
-
Gene segment selection in V(D)J recombination: accessibility and beyond.
-
Gene therapy for prostate cancer: where are we now?
-
Gene transfer and expression in rat cardiac transplants.
-
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.
-
Genetic manipulation of centromere function.
-
Genetic regulation of beta-adrenergic receptors.
-
Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14.
-
Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.
-
Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis.
-
Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.
-
Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged
-
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.
-
Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck.
-
Genome accessibility is widely preserved and locally modulated during mitosis.
-
Genome annotation assessment in Drosophila melanogaster.
-
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
-
Genome-wide identification of regulatory elements in Sertoli cells.
-
Genome-wide methylation analyses in glioblastoma multiforme.
-
Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS.
-
Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).
-
Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio).
-
Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.
-
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
-
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
-
Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans.
-
Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity.
-
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.
-
Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression.
-
Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart.
-
Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.
-
H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity.
-
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
-
HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.
-
HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
-
Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.
-
Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.
-
Heat-induced gene expression as a novel targeted cancer gene therapy strategy.
-
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
-
Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.
-
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
-
High intensity focused ultrasound-induced gene activation in solid tumors.
-
High throughput functional analysis of HIV-1 env genes without cloning.
-
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.
-
High-resolution mapping and characterization of open chromatin across the genome.
-
HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
-
Histone H1 enhances the DNA binding activity of the transcription factor EmBP-1.
-
Histone modifications at human enhancers reflect global cell-type-specific gene expression.
-
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.
-
How petals change their spots: cis-regulatory re-wiring in Clarkia (Onagraceae).
-
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.
-
Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
-
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
-
Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
-
Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region.
-
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
-
Human promoters are intrinsically directional.
-
Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein.
-
Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.
-
Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease.
-
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.
-
Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
-
Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk.
-
Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.
-
Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung.
-
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.
-
Hypoxia and Lou Gehrig.
-
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.
-
Hypoxia reprograms calcium signaling and regulates myoglobin expression.
-
Identification and analysis of eukaryotic promoters: recent computational approaches.
-
Identification and cell type specificity of the tyrosine hydroxylase gene promoter.
-
Identification and characterization of the human parkin gene promoter.
-
Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter.
-
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
-
Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors.
-
Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide.
-
Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling.
-
Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting.
-
Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.
-
Identification of a negative regulatory function for steroid receptors.
-
Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers.
-
Identification of a novel gene linked to parkin via a bi-directional promoter.
-
Identification of a novel repressive element that contributes to neuron-specific gene expression.
-
Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function.
-
Identification of core promoter modules in Drosophila and their application in accurate transcription start site prediction.
-
Identification of functional elements and regulatory circuits by Drosophila modENCODE.
-
Identification of host-induced pathogen genes by differential fluorescence induction reporter systems.
-
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
-
Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.
-
Identification of negative and positive regulatory elements in the human renin gene.
-
Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome.
-
Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
-
Identification of the promoter region of the human betaIGH3 gene.
-
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.
-
Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies.
-
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
-
Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation.
-
Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.
-
Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.
-
In vitro selection of an RNA epitope immunologically cross-reactive with a peptide.
-
In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription.
-
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.
-
In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.
-
In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter.
-
In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer.
-
In vivo regulation of hTERT expression and telomerase activity by androgen.
-
Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.
-
Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers.
-
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
-
Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells.
-
Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes.
-
Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine.
-
Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population.
-
Induction of IL-6 expression by mechanical stress in the trabecular meshwork.
-
Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress.
-
Induction of protein secretory pathway is required for systemic acquired resistance.
-
Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.
-
Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression.
-
Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity.
-
Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach.
-
Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury.
-
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
-
Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression.
-
Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.
-
Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.
-
Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
-
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
-
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
-
Inositol phosphate multikinase dependent transcriptional control.
-
Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose.
-
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.
-
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
-
Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.
-
Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.
-
Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis.
-
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
-
Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma.
-
Interleukin-1 stimulates the beta-amyloid precursor protein promoter.
-
Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.
-
Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.
-
Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
-
Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.
-
Interleukin-6 induces hepcidin expression through STAT3.
-
Interpolated markov chains for eukaryotic promoter recognition.
-
Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4.
-
Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.
-
Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.
-
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.
-
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
-
Is epigenetic inheritance a counterexample to the central dogma?
-
Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.
-
Isolation and characterization of the CYP71D16 trichome-specific promoter from Nicotiana tabacum L.
-
Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide.
-
Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells.
-
Isolation and initial characterization of the 5' flanking region of the human and murine cyclic guanosine monophosphate-phosphodiesterase beta-subunit genes.
-
Isolation and initial characterization of the BRCA2 promoter.
-
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
-
JMJD5 couples with CDK9 to release the paused RNA polymerase II.
-
Joint modeling of DNA sequence and physical properties to improve eukaryotic promoter recognition.
-
Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
-
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
-
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
-
LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
-
Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
-
Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor.
-
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.
-
LexA protein of Escherichia coli represses expression of the Tn5 transposase gene.
-
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.
-
Ligand-specific dynamics of the androgen receptor at its response element in living cells.
-
Light-inducible gene regulation with engineered zinc finger proteins.
-
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.
-
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
-
Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR).
-
Liver X receptors alpha and beta regulate renin expression in vivo.
-
Localization of DIR1 at the tissue, cellular and subcellular levels during Systemic Acquired Resistance in Arabidopsis using DIR1:GUS and DIR1:EGFP reporters.
-
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.
-
Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
-
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
-
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
-
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.
-
Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.
-
Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma.
-
Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.
-
Lung development and repair: contribution of the ciliated lineage.
-
MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis.
-
MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
-
MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb.
-
MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.
-
MGMT immunoexpression in silent subtype 3 pituitary adenomas: possible therapeutic implications.
-
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
-
Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo.
-
Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression.
-
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.
-
Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
-
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.
-
Mapping of the human renin transcription start site: evidence for a single functional promoter.
-
Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation.
-
Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer.
-
Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships.
-
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
-
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
-
Mechanisms of specificity in neuronal activity-regulated gene transcription.
-
Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.
-
Menstrual cyclic change of metastin/GPR54 in endometrium.
-
Metabolic Signaling Drives IFN-γ.
-
Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing.
-
Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients.
-
Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms.
-
Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape.
-
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
-
Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1.
-
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.
-
Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.
-
Modeling folate, one-carbon metabolism, and DNA methylation.
-
Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.
-
Modulation of tissue repair by regeneration enhancer elements.
-
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
-
Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors.
-
Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.
-
Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells.
-
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
-
Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma.
-
Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse.
-
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
-
Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome.
-
Mucin is produced by clara cells in the proximal airways of antigen-challenged mice.
-
Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer.
-
Multimodal regulation of E2F1 gene expression by progestins.
-
Multiple elements may be used for regulation of the GAP-43 gene in different cell-types.
-
Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor.
-
Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
-
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
-
Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription.
-
Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes.
-
Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.
-
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.
-
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
-
Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.
-
Myogenic transcription factors regulate pro-metastatic miR-182.
-
N-myc regulates parkin expression.
-
NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
-
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.
-
NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells.
-
NOS2 regulation of NF-kappaB by S-nitrosylation of p65.
-
NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.
-
NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
-
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements.
-
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.
-
Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10.
-
Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.
-
Network calisthenics: control of E2F dynamics in cell cycle entry.
-
Neurotrophins: transcription and translation.
-
Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults.
-
Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.
-
Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.
-
Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells.
-
No association between the APOE gene and autism.
-
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination.
-
Normal cardiac function in mice with supraphysiological cardiac creatine levels.
-
Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages.
-
Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans.
-
Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.
-
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
-
Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.
-
Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
-
Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.
-
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
-
O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
-
Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
-
Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells.
-
Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic.
-
Optimized regimen for expression of heat-inducible Cre in mice.
-
Optimizing gene transfer to conventional outflow cells in living mouse eyes.
-
Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.
-
Organization of the human aromatase p450 (CYP19) gene.
-
Organization of the human zeta-crystallin/quinone reductase gene (CRYZ).
-
Oscillating gene expression determines competence for periodic Arabidopsis root branching.
-
Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages.
-
Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.
-
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.
-
Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity.
-
OxyR: a molecular code for redox-related signaling.
-
PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
-
PGC-1 coactivators regulate MITF and the tanning response.
-
PIL5, a phytochrome-interacting bHLH protein, regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds.
-
PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer.
-
POWRS: position-sensitive motif discovery.
-
Paired-end analysis of transcription start sites in Arabidopsis reveals plant-specific promoter signatures.
-
Pan-cancer analysis of whole genomes.
-
Parkin is not regulated by the unfolded protein response in human neuroblastoma cells.
-
Partial shotgun sequencing of the Boechera stricta genome reveals extensive microsynteny and promoter conservation with Arabidopsis.
-
Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice.
-
Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment.
-
Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter.
-
Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter.
-
Perspectives on Unidirectional versus Divergent Transcription.
-
Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools.
-
Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.
-
Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
-
Pol II docking and pausing at growth and stress genes in C. elegans.
-
Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.
-
Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.
-
Polymorphisms and evolutionary history of retrotransposon insertions in rice promoters.
-
Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population.
-
Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.
-
Polymorphisms in the PON gene cluster are associated with Alzheimer disease.
-
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
-
Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.
-
Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes.
-
Positive and negative elements regulate human interleukin 3 expression.
-
Possible association between genetic variants in the H2AFX promoter region and risk of adult glioma in a Chinese Han population.
-
Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb.
-
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
-
Precise arrangement of factor-binding sites is required for murine CD4 promoter function.
-
Predicting cell-type-specific gene expression from regions of open chromatin.
-
Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.
-
Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene.
-
Prevalence of transcription promoters within archaeal operons and coding sequences.
-
Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.
-
PrimerZ: streamlined primer design for promoters, exons and human SNPs.
-
Problems for risk assessment of endocrine-active estrogenic compounds.
-
Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.
-
Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers.
-
Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5.
-
Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.
-
Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers.
-
Promoter hypermethylation profile of kidney cancer.
-
Promoter logic.
-
Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
-
Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years.
-
Promoter prediction on a genomic scale--the Adh experience.
-
Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit.
-
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution.
-
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.
-
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
-
Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.
-
Promoting developmental transcription.
-
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.
-
Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer.
-
Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation.
-
Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.
-
Protein-DNA binding dynamics predict transcriptional response to nutrients in archaea.
-
Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro.
-
Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.
-
Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.
-
Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa.
-
RB regulates transcription of the p21/WAF1/CIP1 gene.
-
RNA Pol II accumulates at promoters of growth genes during developmental arrest.
-
RNA replication for the paramyxovirus simian virus 5 requires an internal repeated (CGNNNN) sequence motif.
-
RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions.
-
RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.
-
RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle.
-
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.
-
Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein.
-
Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.
-
Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.
-
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.
-
Redox regulation of the rat hepatocyte iNOS promoter.
-
Regeneration Genetics.
-
Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter.
-
Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.
-
Regulated expression of p18, a major phosphoprotein of leukemic cells.
-
Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.
-
Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1.
-
Regulation of HIV-1 gene expression.
-
Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
-
Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters.
-
Regulation of T cell receptor-alpha gene recombination by transcription.
-
Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.
-
Regulation of alpha-synuclein expression: implications for Parkinson's disease.
-
Regulation of chromatin accessibility for V(D)J recombination.
-
Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells.
-
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
-
Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma.
-
Regulation of systemic acquired resistance by NPR1 and its partners.
-
Regulation of the human interleukin-3 gene.
-
Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
-
Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb.
-
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
-
Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes.
-
Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter.
-
Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
-
Regulatory elements governing transcription in specialized myofiber subtypes.
-
Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
-
Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers.
-
Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.
-
Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.
-
Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.
-
Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.
-
Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA.
-
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes.
-
Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
-
Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus).
-
Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence.
-
Retinoic acid-mediated gene expression in transgenic reporter zebrafish.
-
Retinoid regulation of the zebrafish cyp26a1 promoter.
-
Retroviral vector gene expression in F9 embryonal carcinoma cells.
-
Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia.
-
Reward-related ventral striatum reactivity mediates gender-specific effects of a galanin remote enhancer haplotype on problem drinking.
-
Robust Transgene Expression from Bicistronic mRNA in the Green Alga Chlamydomonas reinhardtii.
-
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
-
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
-
Role of genotype in the cycle of violence in maltreated children.
-
S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.
-
SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo.
-
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
-
STAT6-independent production of IL-4 by mast cells.
-
Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture.
-
Secreted placental alkaline phosphatase as a eukaryotic reporter gene.
-
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
-
Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions.
-
Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.
-
Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium.
-
Sequence specificity incompletely defines the genome-wide occupancy of Myc.
-
Sequences that direct rat tyrosine hydroxylase gene expression.
-
Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities.
-
Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
-
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.
-
Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.
-
Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder.
-
Serotonin transporter genetic variation and the response of the human amygdala.
-
Sex-specific fitness effects of unpredictable early life conditions are associated with DNA methylation in the avian glucocorticoid receptor.
-
Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure.
-
Signal integration and gene induction by a functionally distinct STAT3 phosphoform.
-
Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.
-
Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.
-
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
-
Site-specific RNA cleavage generates the 3' end of a poxvirus late mRNA.
-
Site-specific methylases induce the SOS DNA repair response in Escherichia coli.
-
Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants.
-
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.
-
Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.
-
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.
-
Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.
-
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta.
-
SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila
.
-
Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID.
-
Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.
-
Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat.
-
Spatial Patterning from an Integrated Wnt/β-catenin and Notch/Delta Gene Circuit.
-
Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid.
-
Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.
-
Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.
-
Spontaneous delta- to beta-globin switching in K562 human leukemia cells.
-
Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.
-
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.
-
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
-
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
-
Stimulation of mitotic recombination events by high levels of RNA polymerase II transcription in yeast.
-
Stochastic segment models of eukaryotic promoter regions.
-
Strategies for analysis of gene expression: pulmonary surfactant proteins.
-
Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation.
-
Structural Basis for Virulence Activation of Francisella tularensis.
-
Structural basis of core promoter recognition in a primitive eukaryote.
-
Structural biology of bacterial multidrug resistance gene regulators.
-
Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene.
-
Structure and regulation of the murine Clara cell secretory protein gene.
-
Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
-
Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
-
Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II.
-
Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).
-
Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.
-
Structure of the genes encoding transcription factor IIB and TATA box-binding protein from Drosophila melanogaster.
-
Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
-
Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations.
-
Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene.
-
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
-
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
-
Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
-
Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
-
Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice.
-
Synergistic and tunable human gene activation by combinations of synthetic transcription factors.
-
Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.
-
Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase.
-
Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.
-
T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.
-
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
-
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
-
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
-
TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas.
-
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
-
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.
-
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.
-
TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology.
-
TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.
-
TRPC3 channels confer cellular memory of recent neuromuscular activity.
-
Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.
-
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting.
-
Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.
-
Taste perception: how sweet it is (to be transcribed by you).
-
Template for reporting results of biomarker testing of specimens from patients with carcinoma of the colon and rectum.
-
Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.
-
Tertiary initiation of replication in bacteriophage T4. Deletion of the overlapping uvsY promoter/replication origin from the phage genome.
-
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
-
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
-
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
-
The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
-
The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
-
The DPE, a conserved downstream core promoter element that is functionally analogous to the TATA box.
-
The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes.
-
The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.
-
The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling.
-
The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.
-
The Erwinia amylovora avrRpt2EA gene contributes to virulence on pear and AvrRpt2EA is recognized by Arabidopsis RPS2 when expressed in pseudomonas syringae.
-
The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
-
The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.
-
The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters.
-
The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4.
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The MTE, a new core promoter element for transcription by RNA polymerase II.
-
The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish.
-
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
-
The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins.
-
The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter.
-
The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
-
The SV40 core sequence functions as a repressor element in yeast.
-
The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
-
The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence.
-
The accessible chromatin landscape of the human genome.
-
The activity of a highly promiscuous AP-1 element can be confined to neurons by a tissue-selective repressive element.
-
The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice.
-
The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
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The antisense transcriptomes of human cells.
-
The aromatase enzyme: from cloning to cancer.
-
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
-
The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro.
-
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
-
The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.
-
The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice.
-
The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.
-
The effects of selection against spurious transcription factor binding sites.
-
The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.
-
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.
-
The evolution of transcriptional regulation in eukaryotes.
-
The fallacy of single-agent chemotherapy for cancer.
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The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila.
-
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.
-
The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer.
-
The gamma2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins.
-
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.
-
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
-
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
-
The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2.
-
The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.
-
The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.
-
The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters.
-
The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice.
-
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
-
The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution.
-
The human plasminogen activator inhibitor type I gene promoter targets to kidney.
-
The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes.
-
The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.
-
The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.
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The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus.
-
The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition.
-
The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
-
The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes.
-
The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.
-
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
-
The robustness of the transcriptional response to alterations in morphogenetic gradients.
-
The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective.
-
The serotonin transporter gene-linked polymorphism and negative emotionality: placing single gene effects in the context of genetic background and environment.
-
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
-
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
-
The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus.
-
The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
-
The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
-
The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia.
-
The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
-
The white gene of the tephritid fruit fly Bactrocera tryoni is characterized by a long untranslated 5' leader and a 12kb first intron.
-
The winged-helix DNA-binding motif: another helix-turn-helix takeoff.
-
Threonine biosynthetic genes are essential in Cryptococcus neoformans.
-
Thyroid hormone action at the cellular, genomic and target gene levels.
-
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
-
Tissue specificity of renin promoter activity and regulation in mice.
-
Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice.
-
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression.
-
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.
-
Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo.
-
Transactivation of BKV and SV40 early promoters by BKV and SV40 T-antigens.
-
Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes.
-
Transcription inhibits the replication of autonomously replicating plasmids in human cells.
-
Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level.
-
Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference.
-
Transcription of orthopoxvirus telomeres at late times during infection.
-
Transcription of the RelB gene is regulated by NF-kappaB.
-
Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.
-
Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.
-
Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
-
Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity.
-
Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner.
-
Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs.
-
Transcriptional pausing in a region important for plasmid NR1 replication control.
-
Transcriptional profile of the Arabidopsis root quiescent center.
-
Transcriptional regulation and the evolution of development.
-
Transcriptional regulation of N-acetylglutamate synthase.
-
Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
-
Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.
-
Transcriptional regulation of the mouse presenilin-1 gene.
-
Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation.
-
Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.
-
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
-
Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
-
Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.
-
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.
-
Transgenic indicator mice for studying activated retinoic acid receptors during development.
-
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
-
Transient expression of a winged-helix protein, MNF-beta, during myogenesis.
-
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
-
Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations.
-
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.
-
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.
-
Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia.
-
Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon.
-
Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.
-
Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.
-
Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.
-
Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.
-
Use of RNA polymerase II to transcribe artificial microRNAs.
-
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
-
Vaccinia virus directs the synthesis of early mRNAs containing 5' poly(A) sequences.
-
Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia.
-
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
-
Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells.
-
Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.
-
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
-
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
-
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.
-
Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.
-
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
-
X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.
-
X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.
-
X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells.
-
Yin yang 1 modulates taxane response in epithelial ovarian cancer.
-
[Synthesis of human proinsulin in Escherichia coli cells].
-
[Using Hsp70 promoter to regulate target gene expression in tumor].
-
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
-
beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.
-
beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.
-
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.
-
c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection.
-
c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
-
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
-
cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.
-
dictyBase--a Dictyostelium bioinformatics resource update.
-
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
-
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
-
miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.
-
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
-
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.
-
p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.
-
p53 regulates the expression of the tumor suppressor gene maspin.
-
p53-dependent control of transactivation of the Pen2 promoter by presenilins.
-
rAAV-compatible MiniPromoters for restricted expression in the brain and eye.
-
uORF-mediated translation allows engineered plant disease resistance without fitness costs.
-
Keywords of People
-
Alberts, Susan C.,
Robert F. Durden Distinguished Professor of Biology,
Duke Science & Society
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
-
Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Cell Biology
-
Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
-
Gordan, Raluca Mihaela,
Associate Professor in Biostatistics & Bioinformatics,
Computer Science
-
Grambow, Steven C.,
Assistant Professor of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
-
Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
-
Hirschey, Matthew,
Associate Professor of Medicine,
Pharmacology & Cancer Biology
-
Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
-
Juvvadi, Praveen Rao,
Associate Professor in Pediatrics,
Pediatrics, Infectious Diseases
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
-
Lee, Walter T,
Professor of Head and Neck Surgery and Communication Sciences,
Radiation Oncology
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Pharmacology & Cancer Biology
-
Liton, Paloma Borrajo,
Associate Professor in Ophthalmology,
Pathology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
-
Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute
-
Reddy, Timothy E,
Associate Professor of Biostatistics & Bioinformatics,
Molecular Genetics and Microbiology
-
Schanberg, Laura Eve,
Professor of Pediatrics,
Pediatrics, Rheumatology
-
Schmid, Amy K.,
Associate Professor of Biology,
Duke Science & Society
-
Steinbach, William J.,
Samuel L. Katz Distinguished Professor of Pediatrics,
Duke Innovation & Entrepreneurship
-
Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology
-
Wray, Gregory Allan,
Professor of Biology,
Duke Innovation & Entrepreneurship
-
Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology
-
Zhong, Xiaoping,
Professor of Pediatrics,
Immunology