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Subject Areas on Research
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125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.
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A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial.
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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
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ACP Journal Club. Review: in patients with heart failure, β-blockers reduce mortality but do not differ from each other.
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Acquired dynamic left ventricular outflow tract obstruction complicating acute anterior myocardial infarction: serial echocardiographic and clinical evaluation.
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Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands.
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Anomalous equilibrium binding properties of high-affinity racemic radioligands.
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Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease.
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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.
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Betaxolol and timolol. A comparison of efficacy and side effects.
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Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial.
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Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure.
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Bucindolol: new hopes from reviewing past data.
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Cardiac function and heart failure.
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Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).
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Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.
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Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure.
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Clinical trials in Japan and the United States.
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Combinations of beta-blockers and calcium channel blockers: a cause of malignant perioperative conduction disturbances?
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Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label.
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Crystallizing thinking about the beta2-adrenergic receptor.
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Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use.
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Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.
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Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.
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Dosing of beta-blocker therapy before, during, and after hospitalization for heart failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure).
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Effect of antidepressant drugs in mice lacking the norepinephrine transporter.
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Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation.
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Effect of timolol on aqueous humor protein concentration in humans.
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Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy (from the Multicenter Automatic Defibrillator Implantation Trial-II).
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Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway.
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Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon.
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Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
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Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system.
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Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion.
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Failure of adjuvant heparin to reduce myocardial ischemia in the early treatment of patients with unstable angina.
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Food and Drug Administration: Cardiovascular and Renal Drugs Advisory Committee, 98th meeting, January 6th-7th, 2003.
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Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate.
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Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.
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Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons.
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High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
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Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.
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Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor.
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Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling.
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Impact of nonfatal myocardial infarction on outcomes in patients with advanced heart failure and the effect of bucindolol therapy.
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Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.
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In Response.
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
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Inhibition of premature labor: a multicenter comparison of ritodrine and ethanol.
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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
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Iodine-123 MIBG imaging before treatment of heart failure with carvedilol to predict improvement of left ventricular function and exercise capacity.
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Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
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Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
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MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.
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Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.
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Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.
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Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.
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Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.
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Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors.
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Molecular biology of adrenergic receptors in the rat and frog central nervous system.
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Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.
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New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.
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Nicardipine is superior to esmolol for the management of postcraniotomy emergence hypertension: a randomized open-label study.
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Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors.
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Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure.
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Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase.
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Photoaffinity labeling of beta-adrenergic receptors in mammalian tissues.
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Photoaffinity labeling of the beta-adrenergic receptor.
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Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: degradation of the Mr = 49,000 protein explains apparent heterogeneity.
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Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity.
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Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.
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Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure.
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Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial.
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Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism.
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Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction.
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Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure.
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Rationale and design of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy for Heart Failure (IMPACT-HF) study.
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Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
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Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor.
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Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
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Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe.
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The Initiation Management Predischarge Process for Assessment of Carvedilol Therapy for Heart Failure (IMPACT-HF) Study: design and implications.
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The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.
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When the heart runs out of heartbeats: treatment options for refractory end-stage heart failure.
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Which beta-blocker for heart failure?
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β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.
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β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.
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β1-Blockade increases maximal apnea duration in elite breath-hold divers.
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