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Subject Areas on Research
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6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.
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A double-blind study comparing benoxaprofen, aspirin, and benoxaprofen plus aspirin in patients with rheumatoid arthritis.
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Acylcarnitines in amniotic fluid: application to the prenatal diagnosis of propionic acidaemia.
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Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry.
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Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism.
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Application of continuous-flow liquid chromatography/fast-atom bombardment mass spectrometry to the analysis of diagnostic acylcarnitines in human urine.
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Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease.
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Clinical pharmacology of benoxaprofen.
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Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
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Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease.
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Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid.
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Does dopamine contribute to striatal damage caused by impaired mitochondrial function?
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Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease.
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Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat.
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Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.
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Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.
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Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.
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First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation.
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First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial.
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Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.
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Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB.
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Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia.
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Inherited methylmalonyl CoA mutase apoenzyme deficiency in human fibroblasts: evidence for allelic heterogeneity, genetic compounds, and codominant expression.
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Inhibition of Factor Xa : a potential target for the development of new anticoagulants.
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Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot.
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Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.
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Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver.
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Interrelationship of Na, HCO3, and volatile fatty acid transport by equine large intestine.
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Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.
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L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia.
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Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation.
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Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
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MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.
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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
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Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
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Novel constructs for thrombin inhibition.
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Opposite modulation of capsaicin-evoked substance P release by glutamate receptors.
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Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics.
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Parenteral nutrition in propionic and methylmalonic acidemia.
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Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.
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Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
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Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.
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Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat.
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Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.
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Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
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Purine-specific reapir of beta-propiolacton-induced DNA damage in mouse skin cells.
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Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution.
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Rapid prenatal and postnatal detection of inborn errors of propionate, methylmalonate, and cobalamin metabolism: a sensitive assay using cultured cells.
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Role of prostacyclin in the cardiovascular response to thromboxane A2.
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Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.
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Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.
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The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures.
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The efficacy, tolerability, and safety of 1200 mg/d of oxaprozin and 1500 mg/d of nabumetone in the treatment of patients with osteoarthritis of the knee.
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Thyroid hormones and 3,5-diiodothyropropionic acid: new keys for new locks.
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Tissue distribution studies of [18F]haloperidol, [18F]-beta-(4-fluorobenzoyl)propionic acid, and [82Br]bromperidol by external scintigraphy.
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Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor.
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Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.