Prostaglandin-Endoperoxide Synthases
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Subject Areas on Research
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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
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A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.
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A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation.
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A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
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A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates.
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ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells.
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Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
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Activation of lipid metabolism contributes to interleukin-8 production during Chlamydia trachomatis infection of cervical epithelial cells.
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Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism.
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Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors.
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Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.
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Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
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Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.
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Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.
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Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds.
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Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet.
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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
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COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil.
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COX-2-derived prostacyclin modulates vascular remodeling.
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
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Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.
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Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.
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Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
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Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas.
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Cyclooxygenase-2 (COX-2) expression in human meningioma as a function of tumor grade.
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Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
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Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
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Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition.
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Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
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Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
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E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
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Effect of cyclooxygenase inhibition on retinal and choroidal blood flow during hypercarbia in newborn piglets.
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Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
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Effect of inhibitors of arachidonic acid metabolism on corneal reepithelialization in the rat.
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Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats.
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Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor.
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Eicosanoids: lipid mediators of inflammation in transplantation.
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Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells.
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Fish oil feeding modulates leukotriene production in murine lupus nephritis.
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Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
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Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
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IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
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Immunohistochemical localization of prostaglandin endoperoxide synthase in human fetal membranes and decidua.
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Impaired systemic production of prostaglandin E2 in children with cerebral malaria.
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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
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Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.
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Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
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Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
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Induction of uterine prostaglandin H synthase 2 by estradiol following fetal adrenalectomy.
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Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
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Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells.
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Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
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Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
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Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria.
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Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism.
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Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.
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Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.
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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.
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Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.
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Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
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Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation.
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Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair.
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Nonsteroidal antiinflammatory drug use among patients with GI bleeding.
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Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
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Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
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Parecoxib sodium, an injectable COX-2-specific inhibitor, does not affect unfractionated heparin-regulated blood coagulation parameters.
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Perioperative COX-2 inhibitors: knowledge and challenges.
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Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.
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Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
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Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
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Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters.
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Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.
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Prostaglandin mediates premature delivery in pregnant sheep induced by estradiol at 121 days of gestational age.
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Prostanoids and blood pressure: which way is up?
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Pulmonary vascular and airway responses to endothelin-1 are mediated by different mechanisms in the cat.
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Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.
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Pyridazinones as selective cyclooxygenase-2 inhibitors.
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Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.
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Regulation of the prostaglandin enzymatic system by estradiol and progesterone in nonpregnant sheep cervix.
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Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
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Role for thromboxane receptors in angiotensin-II-induced hypertension.
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Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo.
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Role of microsomal prostaglandin E synthase 1 in the kidney.
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Role of prostacyclin in the cardiovascular response to thromboxane A2.
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Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3.
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Sufficient progesterone-priming prior to estradiol stimulation is required for optimal induction of the cervical prostaglandin system in pregnant sheep at 0.7 gestations.
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Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
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The effects of physician specialty and patient comorbidities on the use and discontinuation of coxibs.
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The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
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Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.
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Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells.