Prostaglandin-Endoperoxide Synthases
-
Subject Areas on Research
-
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
-
A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.
-
A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation.
-
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
-
A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates.
-
ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells.
-
Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
-
Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism.
-
Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors.
-
Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.
-
Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
-
Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.
-
Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.
-
Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds.
-
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
-
COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil.
-
COX-2-derived prostacyclin modulates vascular remodeling.
-
Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers.
-
Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
-
Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.
-
Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
-
Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
-
Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
-
Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition.
-
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
-
Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
-
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
-
Effect of cyclooxygenase inhibition on retinal and choroidal blood flow during hypercarbia in newborn piglets.
-
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
-
Effect of inhibitors of arachidonic acid metabolism on corneal reepithelialization in the rat.
-
Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats.
-
Eicosanoids: lipid mediators of inflammation in transplantation.
-
Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells.
-
Fish oil feeding modulates leukotriene production in murine lupus nephritis.
-
Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
-
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
-
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
-
Immunohistochemical localization of prostaglandin endoperoxide synthase in human fetal membranes and decidua.
-
Impaired systemic production of prostaglandin E2 in children with cerebral malaria.
-
In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
-
Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.
-
Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
-
Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
-
Induction of uterine prostaglandin H synthase 2 by estradiol following fetal adrenalectomy.
-
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
-
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
-
Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
-
Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria.
-
Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism.
-
Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.
-
Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.
-
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.
-
Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.
-
Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
-
Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation.
-
Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair.
-
Nonsteroidal antiinflammatory drug use among patients with GI bleeding.
-
Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
-
Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
-
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.
-
Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
-
Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
-
Prostaglandin mediates premature delivery in pregnant sheep induced by estradiol at 121 days of gestational age.
-
Prostanoids and blood pressure: which way is up?
-
Pulmonary vascular and airway responses to endothelin-1 are mediated by different mechanisms in the cat.
-
Pyridazinones as selective cyclooxygenase-2 inhibitors.
-
Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.
-
Regulation of the prostaglandin enzymatic system by estradiol and progesterone in nonpregnant sheep cervix.
-
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
-
Role for thromboxane receptors in angiotensin-II-induced hypertension.
-
Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo.
-
Role of microsomal prostaglandin E synthase 1 in the kidney.
-
Role of prostacyclin in the cardiovascular response to thromboxane A2.
-
Sufficient progesterone-priming prior to estradiol stimulation is required for optimal induction of the cervical prostaglandin system in pregnant sheep at 0.7 gestations.
-
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
-
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
-
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
-
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
-
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
-
The effects of physician specialty and patient comorbidities on the use and discontinuation of coxibs.
-
The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
-
Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.
-
Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells.