Protein Conformation

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  Subject Areas on Research

  • "Active" conformation of an inactive semi-synthetic ribonuclease-S. 
  • 16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. 
  • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. 
  • A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data. 
  • A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. 
  • A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. 
  • A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. 
  • A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation. 
  • A Unified Model for Treadmilling and Nucleation of Single-Stranded FtsZ Protofilaments. 
  • A carbon monoxide irreducible form of cytochrome c oxidase and other unusual properties of the "monomeric" shark enzyme. 
  • A carcinoembryonic antigen (CEA) binding protein from ascites influences CEA uptake by macrophages. 
  • A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography. 
  • A colloidal Au monolayer modulates the conformation and orientation of a protein at the electrode/solution interface. 
  • A comparative study of crosslinked and noncrosslinked fibrin from the major classes of vertebrates. 
  • A comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma. 
  • A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. 
  • A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. 
  • A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy. 
  • A crystal clear view of the beta2-adrenergic receptor. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A family of receptors coupled to guanine nucleotide regulatory proteins. 
  • A golden era for understanding enzyme mechanisms. 
  • A gradient-directed Monte Carlo approach for protein design. 
  • A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase. 
  • A kinetic study of the subunit dissociation and reassembly of rabbit muscle phosphofructokinase. 
  • A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases. 
  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. 
  • A new generation of crystallographic validation tools for the protein data bank. 
  • A new structural state of myosin. 
  • A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. 
  • A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. 
  • A peptide model of a protein folding intermediate. 
  • A refocused and optimized HNCA: increased sensitivity and resolution in large macromolecules. 
  • A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion. 
  • A self-assembling peptide acting as an immune adjuvant. 
  • A statistical thermodynamic model of the protein ensemble. 
  • A structural basis for lithium and substrate binding of an inositide phosphatase. 
  • A structural pathway for activation of the kinesin motor ATPase. 
  • A structural pathway for signaling in the E46Q mutant of photoactive yellow protein. 
  • A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin. 
  • A topological data analytic approach for discovering biophysical signatures in protein dynamics. 
  • Ab initio based calculations of electron-transfer rates in metalloproteins. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Accelerating self-consistent field convergence with the augmented Roothaan-Hall energy function. 
  • Activated conformers of Escherichia coli sulfite reductase heme protein subunit. 
  • Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Adhesin presentation in bacteria requires molecular chaperones and ushers. 
  • Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop. 
  • Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. 
  • Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers. 
  • Affinity-purified antibody as a probe of RNA polymerase II subunit structure. 
  • Agonist-induced increase in apparent beta-adrenergic receptor size. 
  • Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding. 
  • Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). 
  • Allosteric intermediates indicate R2 is the liganded hemoglobin end state. 
  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme. 
  • Allosteric transition intermediates modelled by crosslinked haemoglobins. 
  • Alpha-carbon coordinates for bovine Cu,Zn superoxide dismutase. 
  • Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. 
  • Alternate states of proteins revealed by detailed energy landscape mapping. 
  • Amino acid preferences for specific locations at the ends of alpha helices. 
  • An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation. 
  • An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An algorithm for smoothly tessellating beta-sheet structures in proteins. 
  • An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. 
  • An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants. 
  • An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. 
  • An equilibrium binding study of the interaction of fructose 6-phosphate and fructose 1,6-bisphosphate with rabbit muscle phosphofructokinase. 
  • An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins. 
  • An interview with Jane Richardson. 
  • An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor. 
  • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. 
  • Analysis of experimental time-resolved crystallographic data by singular value decomposition. 
  • Analysis of protein folding and function using backbone modified proteins. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Analysis of thiolester bond cleavage-dependent conformational changes in binary alpha 2-macroglobulin-proteinase complexes. 
  • Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data. 
  • Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. 
  • Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. 
  • AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. 
  • Anti-DNA antibodies in systemic lupus erythematosus: a case of mistaken identity? 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Antiadhesive properties of a quaternary structure-specific hybridoma antibody against type 1 fimbriae of Escherichia coli. 
  • Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antidote control of aptamer therapeutics: the road to a safer class of drug agents. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • Apolipoprotein C-III/sphingomyelin recombinants: formation, isolation, and characterization. 
  • Application of random peptide phage display to the study of nuclear hormone receptors. 
  • Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data. 
  • Asparagine and glutamine rotamers: B-factor cutoff and correction of amide flips yield distinct clustering. 
  • Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation. 
  • Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin. 
  • Assessment of detailed conformations suggests strategies for improving cryoEM models: Helix at lower resolution, ensembles, pre-refinement fixups, and validation at multi-residue length scale. 
  • Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Atomic Resolution Cryo-EM Structure of β-Galactosidase. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Atomic force microscopy captures folded ribosome bound nascent chains. 
  • Autofix for backward-fit sidechains: using MolProbity and real-space refinement to put misfits in their place. 
  • Autoimmune epitopes in messenger RNA. 
  • Automated image acquisition and processing using a new generation of 4K x 4K CCD cameras for cryo electron microscopic studies of macromolecular assemblies. 
  • BBK* (Branch and Bound Over K*): A Provable and Efficient Ensemble-Based Protein Design Algorithm to Optimize Stability and Binding Affinity Over Large Sequence Spaces. 
  • Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions. 
  • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. 
  • Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. 
  • Beta-arrestins and cell signaling. 
  • Binding of native and reduced and carbamidomethylated hGH to rabbit liver plasma membranes. 
  • Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin. 
  • Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • Binding stoichiometry and structural mapping of the epsilon polypeptide of chloroplast coupling factor 1. 
  • Biochemical and structural studies of tenascin/hexabrachion proteins. 
  • Biochemistry. Exciting structures. 
  • Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. 
  • Biological and clinical aspects of hyperthermia in cancer therapy. 
  • Biophysical highlights from 54 years of macromolecular crystallography. 
  • Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. 
  • Bovine serum albumin conformation on methyl and amine functionalized surfaces compared by scanning force microscopy. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin. 
  • Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. 
  • Bridged peptide macrocycles as ligands for PDZ domain proteins. 
  • Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding. 
  • Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions. 
  • C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. 
  • C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation. 
  • CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. 
  • CD4 mimetics sensitize HIV-1-infected cells to ADCC. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. 
  • Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. 
  • Calmodulin activation of target enzymes. Consequences of deletions in the central helix. 
  • Calmodulin binds to caldesmon in an antiparallel manner. 
  • Calmodulin structure refined at 1.7 A resolution. 
  • Calmodulin: a prototypical calcium sensor. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Catalytic mechanism of 4-oxalocrotonate tautomerase: significances of protein-protein interactions on proton transfer pathways. 
  • Cathepsin B1. A lysosomal enzyme that degrades native collagen. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. 
  • Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. 
  • Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase. 
  • Characterization and crystal structure of Escherichia coli KDPGal aldolase. 
  • Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. 
  • Characterization of a major hepatic calmodulin acceptor protein (CAP-60). 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Characterization of fragment E from fibrinogen and cross-linked fibrin. 
  • Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. 
  • Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. 
  • Characterization of the SarA virulence gene regulator of Staphylococcus aureus. 
  • Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase. 
  • Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. 
  • Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Characterizing aqueous solution conformations of a peptide backbone with theoretical analysis of the Raman optical activity spectra 
  • Chasing acyl carrier protein through a catalytic cycle of lipid A production. 
  • Chemical cross-linking studies of chloroplast coupling factor 1. 
  • Chemical modification and fluorescence studies of chloroplast coupling factor. 
  • Chemistry and biology of the ramoplanin family of peptide antibiotics. 
  • Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. 
  • Chloride and pH dependence of cooperative interactions in Limulus polyphemus hemocyanin. 
  • Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. 
  • Chloroplast coupling factor 1: dependence of rotational correlation time on polypeptide composition. 
  • Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. 
  • Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations. 
  • Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. 
  • Chutes and Ladders: the search for protein kinases that act on AMPK. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. 
  • Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 
  • Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling. 
  • Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. 
  • Co-operativity in protein-protein association. The structure and stability of the actin filament. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Cocrystal structure of an editing complex of Klenow fragment with DNA. 
  • Codon usage regulates human KRAS expression at both transcriptional and translational levels. 
  • Collagen, collagenase and clinicians. 
  • Colloid osmotic pressure of steer alpha- and beta-crystallins: possible functional roles for lens crystallin distribution and structural diversity. 
  • Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. 
  • Comparative analyses of mechanistic differences among antiestrogens. 
  • Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. 
  • Competition between monomeric and dimeric crystals in schematic models for globular proteins. 
  • Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence. 
  • Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. 
  • Computational crystallization. 
  • Computational design of a biologically active enzyme. 
  • Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Computing van der Waals energies in the context of the rotamer approximation. 
  • Concentration of protein in fibrin fibers and fibrinogen polymers determined by refractive index matching. 
  • Concentration-dependent effects of anions on the anaerobic oxidation of hemoglobin and myoglobin. 
  • Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes. 
  • Conformation change of horseradish peroxidase in lipid membrane. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564. 
  • Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. 
  • Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3. 
  • Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. 
  • Conformational changes at the carboxyl terminus of Galpha occur during G protein activation. 
  • Conformational changes in the photocycle of Anabaena sensory rhodopsin: absence of the Schiff base counterion protonation signal. 
  • Conformational changes of FtsZ reported by tryptophan mutants. 
  • Conformational changes of beta-lactoglobulin induced by anionic phospholipid. 
  • Conformational changes of purine repressor DNA-binding domain upon complexation with DNA. 
  • Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. 
  • Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --> Arg. 
  • Conformational kinetics reveals affinities of protein conformational states. 
  • Conformational plasticity in the selectivity filter of the TRPV2 ion channel. 
  • Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF. 
  • Conformational selection or induced fit: a flux description of reaction mechanism. 
  • Conformationally averaged score functions for electronic propagation in proteins. 
  • Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant. 
  • Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Constructing atomic structural models into cryo-EM densities using molecular dynamics - Pros and cons. 
  • Construction of a fluorescent biosensor family. 
  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. 
  • Continuous Interdomain Orientation Distributions Reveal Components of Binding Thermodynamics. 
  • Control of protein-ligand recognition using a stimuli-responsive polymer. 
  • Controlling the SARS-CoV-2 spike glycoprotein conformation. 
  • Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins. 
  • Conversion of a maltose receptor into a zinc biosensor by computational design. 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design. 
  • Copper-chelatin: isolation from various eucaryotic sources. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Coupling coherence distinguishes structure sensitivity in protein electron transfer. 
  • Cross-linked fibrinogen dimers demonstrate a feature of the molecular packing in fibrin fibers. 
  • Crucial role for the VWF A1 domain in binding to type IV collagen. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. 
  • Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge. 
  • Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. 
  • Cryo-EM structure of a mitochondrial calcium uniporter. 
  • Cryo-electron microscopy structure of the TRPV2 ion channel. 
  • Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. 
  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
  • Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis. 
  • Crystal structure of MtaN, a global multidrug transporter gene activator. 
  • Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. 
  • Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction. 
  • Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. 
  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. 
  • Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Crystal structure of the transcription activator BmrR bound to DNA and a drug. 
  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. 
  • Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus. 
  • Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. 
  • Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. 
  • Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis. 
  • Crystallization and preliminary X-ray investigation of calmodulin. 
  • Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor. 
  • Crystallization and preliminary diffraction analysis of a hyperthermostable DNA polymerase from a Thermococcus archaeon. 
  • Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis. 
  • Crystallization of the bifunctional biotin operon repressor. 
  • Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae. 
  • Crystallizing thinking about the beta2-adrenergic receptor. 
  • Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. 
  • Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. 
  • Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. 
  • Crystallographic studies of calmodulin. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction. 
  • DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. 
  • De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence. 
  • DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. 
  • Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. 
  • Defining G protein beta gamma specificity for effector recognition. 
  • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics. 
  • Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. 
  • Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States. 
  • Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells. 
  • Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium. 
  • Describing patterns of protein tertiary structure. 
  • Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies. 
  • Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. 
  • Determinants of Tenascin-C and HIV-1 envelope binding and neutralization. 
  • Determinants of backbone dynamics in native BPTI: cooperative influence of the 14-38 disulfide and the Tyr35 side-chain. 
  • Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. 
  • Development of a Grp94 inhibitor. 
  • Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction. 
  • Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation. 
  • Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. 
  • Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. 
  • Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). 
  • Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. 
  • Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states. 
  • Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. 
  • Discovering the landscape of protein modifications. 
  • Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer. 
  • Dissection of the molecular circuitry controlling virulence in Francisella tularensis. 
  • Distinct Regions of the Haloferax volcanii Dolichol Phosphate-Mannose Synthase AglD Mediate the Assembly and Subsequent Processing of the Lipid-Linked Mannose. 
  • Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. 
  • Domain interactions in oxidized and reduced forms of rat liver sulfite oxidase. 
  • Domain structure of phytochrome from Avena sativa visualized by electron microscopy. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways. 
  • Dominant kinetic paths on biomolecular binding-folding energy landscape. 
  • Drug design from the cryptic inhibitor envelope. 
  • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 
  • Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5). 
  • Dynamic interaction between a Drosophila transcription factor and RNA polymerase II. 
  • Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide. 
  • Effect of colloidal gold size on the conformational changes of adsorbed cytochrome c: probing by circular dichroism, UV-visible, and infrared spectroscopy. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effect of electrode surface microstructure on electron transfer induced conformation changes in cytochrome c monitored by in situ UV and CD spectroelectrochemistry. 
  • Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex. 
  • Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers. 
  • Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor. 
  • Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis. 
  • Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. 
  • Effect of oxygen and allosteric effects on structural stability of oligomeric hemocyanins of the arthropod, Limulus polyphemus, and the mollusc, Helix pomatia. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Elastic response, buckling, and instability of microtubules under radial indentation. 
  • Elastin-like polypeptides as models of intrinsically disordered proteins. 
  • Elastin-like polypeptides: biomedical applications of tunable biopolymers. 
  • Electron microscope study of native and crosslinked rabbit muscle phosphofructokinase. 
  • Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts. 
  • Electron microscopy of human factor VIII/Von Willebrand glycoprotein: effect of reducing reagents on structure and function. 
  • Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. 
  • Electron paramagnetic resonance of the tungsten derivative of rat liver sulfite oxidase. 
  • Electron-tunneling pathways in proteins. 
  • Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. 
  • Elucidating solvent contributions to solution reactions with ab initio QM/MM methods. 
  • Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain. 
  • Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. 
  • Energy Transduction in Nitrogenase. 
  • Enhanced protein flexibility caused by a destabilizing amino acid replacement in BPTI. 
  • Erythrocyte membrane tropomyosin. Purification and properties. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling. 
  • Estimating the probability of polyreactive antibodies 4E10 and 2F5 disabling a gp41 trimer after T cell-HIV adhesion. 
  • Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. 
  • Estrogen receptor interconversion, factors regulating conformation and functions. 
  • Evaluating the quality of NMR structures by local density of protons. 
  • Evaluation of ligand-dependent changes in AR structure using peptide probes. 
  • Evolution of a σ-(c-di-GMP)-anti-σ switch. 
  • Evolving the use of peptides as components of biomaterials 
  • Exploring steric constraints on protein mutations using MAGE/PROBE. 
  • Expression analysis of endoglin missense and truncation mutations: insights into protein structure and disease mechanisms. 
  • Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. 
  • Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase. 
  • Fibrillar peptide gels in biotechnology and biomedicine. 
  • Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis. 
  • Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand. 
  • Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Fluorescence energy transfer measurements in rabbit muscle phosphofructokinase. 
  • Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements. 
  • Fluorescent probes as a measure of conformational alterations induced by nucleophilic modification and proteolysis of bovine alpha 2-macroglobulin. 
  • Fluorescent probes as indicators of conformation changes in transducin on activation. 
  • Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates. 
  • Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity. 
  • From promiscuity to precision: protein phosphatases get a makeover. 
  • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 
  • Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Functional properties of carboxypeptidase-digested hemoglobins. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. 
  • Functional significance of the central helix in calmodulin. 
  • Functions of cytochrome c in regulation of electron transfer and protein folding. 
  • Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. 
  • G Protein-coupled Receptor Biased Agonism. 
  • G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G-protein-coupled receptors. Turned on to ill effect. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. 
  • Genetic approaches to molecular motors. 
  • Genetic control of the immune response to staphylococcal nuclease in mice. 
  • Genetic heterogeneity of diffuse large B-cell lymphoma. 
  • Genomic structure and amino acid sequence domains of the human La autoantigen. 
  • Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Glycerol-induced unraveling of the tight helical conformation of Escherichia coli type 1 fimbriae. 
  • Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. 
  • Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. 
  • HIV-1 Envelope Conformation, Allostery, and Dynamics. 
  • HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • Handedness of crossover connections in beta sheets. 
  • Harnessing Environmental Ca2+ for Extracellular Protein Thermostabilization. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • Heat-dependent opening of TRPV1 in the presence of capsaicin. 
  • Helix lap-joints as ion-binding sites: DNA-binding motifs and Ca-binding "EF hands" are related by charge and sequence reversal. 
  • Hemoglobin Deer Lodge (beta 2 His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82. 
  • Hemoglobins from trout: structural and functional properties. 
  • Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide. 
  • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. 
  • Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. 
  • Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor. 
  • Heterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis. 
  • Hexabrachion proteins in embryonic chicken tissues and human tumors. 
  • Hierarchy of RNA functional dynamics. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • High resolution AFM topographs of the Escherichia coli water channel aquaporin Z. 
  • High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Hormones, receptors, and cyclic AMP: their role in target cell refractoriness. 
  • How Gsalpha activates adenylyl cyclase. 
  • How do enzymes really work? 
  • How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides. 
  • How does protein architecture facilitate the transduction of ATP chemical-bond energy into mechanical work? The cases of nitrogenase and ATP binding-cassette proteins. 
  • How the EcoRI endonuclease recognizes and cleaves DNA. 
  • Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. 
  • Hydralazine differentially increases mRNAs for the alpha and beta subunits of prolyl 4-hydroxylase whereas it decreases pro alpha 1(I) collagen mRNAs in human skin fibroblasts. 
  • Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides. 
  • Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of a residue critical for maintaining the functional conformation of BPTI. 
  • Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4. 
  • Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides. 
  • Identification of amino acid sequences in fibrinogen gamma -chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3. 
  • Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase. 
  • Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Identification of the iron-sulfur center of spinach ferredoxin-nitrite reductase as a tetranuclear center, and preliminary EPR studies of mechanism. 
  • Image reconstruction in electron microscopy: enhancement of periodic structure by optical filtering. 
  • Immunodominant sites of human T cell lymphotropic virus type 1 envelope protein for murine helper T cells. 
  • Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes. 
  • Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. 
  • Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits. 
  • Impact of vibrational entropy on the stability of unsolvated peptide helices with increasing length 
  • Improved AlphaFold modeling with implicit experimental information. 
  • Improved chemistry restraints for crystallographic refinement by integrating the Amber force field into Phenix. 
  • In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function. 
  • In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. 
  • Incorporation of non-proteolytic proteins by murine alpha2-macroglobulin. 
  • Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase. 
  • Independent analysis of bait region cleavage dependent and thiolester bond cleavage dependent conformational changes by cross-linking of alpha 2-macroglobulin with cis-dichlorodiammineplatinum(II) and dithiobis(succinimidyl propionate). 
  • Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor. 
  • Influence of allosteric ligands on the activity and aggregation of rabbit muscle phosphofructokinase. 
  • Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. 
  • Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. 
  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. 
  • Insect sodium channels and insecticide resistance. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Insights into the nature of DNA binding of AbrB-like transcription factors. 
  • Integrating statistical pair potentials into protein complex prediction. 
  • Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. 
  • Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2. 
  • Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
  • Interpretation of electron density maps. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Intrinsic disorder drives N-terminal ubiquitination by Ube2w. 
  • Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis. 
  • Investigation of the conserved reentrant membrane helix in the monotopic phosphoglycosyl transferase superfamily supports key molecular interactions with polyprenol phosphate substrates. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Ion channels: an open and shut case. 
  • Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. 
  • Isolation and characterization of the major apolipoprotein from chicken high density lipoproteins. 
  • Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses. 
  • Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. 
  • K channel subconductance levels result from heteromeric pore conformations. 
  • KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. 
  • Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. 
  • Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease. 
  • Kinesin motors as molecular machines. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch. 
  • Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. 
  • Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. 
  • Kinetics of allosteric enzymes. 
  • Kinetics of protein-protein association explained by Brownian dynamics computer simulation. 
  • Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors (FeII, CoII, and ZnII) and their isokinetic relationship. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis. 
  • Lateral packing of protofibrils in fibrin fibers and fibrinogen polymers. 
  • Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. 
  • Ligand concentration regulates the pathways of coupled protein folding and binding. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Ligation-state hydrogen exchange: coupled binding and folding equilibria in ribonuclease P protein. 
  • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Lipid molecules induce p38α activation via a novel molecular switch. 
  • Lipoprotein(a) and its role in atherothrombotic disease. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Localization of the activation gate for small conductance Ca2+-activated K+ channels. 
  • Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor. 
  • Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins. 
  • Long range dynamic effects of point-mutations trap a response regulator in an active conformation. 
  • Long-range electron transfer in myoglobin. 
  • Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992. 
  • Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). 
  • MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes. 
  • Making the invisible enemy visible. 
  • Manganese superoxide dismutases from Escherichia coli and from yeast mitochondria: preliminary x-ray crystallographic studies. 
  • Manipulation of ligand binding affinity by exploitation of conformational coupling. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Mapping the domain structure of human erythrocyte adducin. 
  • Measuring similarity between dynamic ensembles of biomolecules. 
  • Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc. 
  • Mechanical unfolding of an ankyrin repeat protein. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. 
  • Mechanism of corepressor-mediated specific DNA binding by the purine repressor. 
  • Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. 
  • Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. 
  • Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. 
  • Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system. 
  • Membrane protein structure determination using cryo-electron tomography and 3D image averaging. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Metalloprotein design. 
  • Microcantilever sensing and actuation with end-grafted stimulus-responsive elastin-like polypeptides. 
  • Microtubule surface lattice and subunit structure and observations on reassembly. 
  • Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. 
  • Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability. 
  • Model of alpha 2-macroglobulin structure and function. 
  • Modeling and superposition of multiple protein structures using affine transformations: analysis of the globins. 
  • Modeling of bias for the analysis of receptor signaling in biochemical systems. 
  • Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. 
  • Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. 
  • Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats. 
  • Molecular biology of adrenergic receptors. 
  • Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. 
  • Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. 
  • Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. 
  • Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. 
  • Molecular conformation of erabutoxin b; atomic coordinates at 2.5 A resolution. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. 
  • Molecular mechanics simulation of the interaction of estrogen receptor with estrogen regulatory element. 
  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. 
  • Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. 
  • Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. 
  • Molecular mechanisms of BK channel activation. 
  • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. 
  • Molecular mechanisms of dominant negative activity by nuclear hormone receptors. 
  • Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors. 
  • Molecular studies of human renin structure and synthesis using monoclonal antibodies. 
  • Molprobity's ultimate rotamer-library distributions for model validation. 
  • Molybdopterin from molybdenum and tungsten enzymes. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. 
  • Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP. 
  • Motor proteins 1: kinesins. 
  • Motor proteins. 1: kinesins. 
  • Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. 
  • Multiple conformational changes in enzyme catalysis. 
  • Multiple conformations of PEVK proteins detected by single-molecule techniques. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. 
  • Multiscale implementation of infinite-swap replica exchange molecular dynamics. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity. 
  • Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein. 
  • Mutations in the active site of Escherichia coli phosphofructokinase. 
  • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. 
  • Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex. 
  • Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus. 
  • Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. 
  • NAD+ modulates p53 DNA binding specificity and function. 
  • NMR structural characterization of the CDK inhibitor p19INK4d. 
  • NMR structure of activated CheY. 
  • NMR studies of a complex of deuterated calmodulin with melittin. 
  • NMR-based Structural Analysis of Threonylcarbamoyl-AMP Synthase and Its Substrate Interactions. 
  • NMR-derived solution conformations of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus. 
  • Native fluorescence and mag-indo-1-protein interaction as tools for probing unfolding and refolding sequences of the bovine serum albumin subdomain in the presence of guanidine hydrochloride. 
  • Neck-linker length dependence of processive Kinesin-5 motility. 
  • Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. 
  • Negatively stained vinblastine aggregates. 
  • Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. 
  • Neutralization epitopes of the HIV-1 primary isolate DH012. 
  • Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls. 
  • New insights into the proton-dependent oxygen affinity of Root effect haemoglobins. 
  • New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. 
  • Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. 
  • Nuclear RNA-binding proteins. 
  • Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Observation of 17O effects on MoV EPR spectra in sulfite oxidase, xanthine dehydrogenase, and MoO(SC6H5)4-. 
  • Oligomeric structure and tissue distribution of ficolins from mouse, pig and human. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. 
  • Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay. 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. 
  • Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies. 
  • Oxygen binding domains of Helisoma trivolvis hemoglobin. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis. 
  • Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. 
  • Pathway analysis of protein electron-transfer reactions. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. 
  • Periplasmic binding proteins: a versatile superfamily for protein engineering. 
  • Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. 
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. 
  • Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. 
  • Phenylalanine 30 plays an important role in receptor binding of verotoxin-1. 
  • Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. 
  • Photoinduced electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the Rhodobacter sphaeroides cytochrome bc(1) complex. Effects of pH, temperature, and driving force. 
  • Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits. 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin. 
  • Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. 
  • Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. 
  • Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. 
  • Plant Immunity Requires Conformational Changes of NPR1 via S-Nitrosylation and Thioredoxins 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. 
  • Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative? 
  • Prediction of secondary structure for Eco RI endonuclease. 
  • Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition. 
  • Preliminary X-ray diffraction studies on the hemoprotein subunit of Escherichia coli sulfite reductase. 
  • Preserving the Boltzmann ensemble in replica-exchange molecular dynamics. 
  • Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Priming with DNA Expressing Trimeric HIV V1V2 Alters the Immune Hierarchy Favoring the Development of V2-Specific Antibodies in Rhesus Macaques. 
  • Probing for Binding Regions of the FtsZ Protein Surface through Site-Directed Insertions: Discovery of Fully Functional FtsZ-Fluorescent Proteins. 
  • Probing the folding and unfolding dynamics of secondary and tertiary structures in a three-helix bundle protein. 
  • Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry. 
  • Probing the stability of native and activated forms of alpha2-macroglobulin. 
  • Processing of intermediates in multienzyme complexes. 
  • Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. 
  • Prokaryotic transcription regulators: more than just the helix-turn-helix motif. 
  • Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression. 
  • Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site. 
  • Protection from nitrosative stress: a central role for microbial flavohemoglobin. 
  • Protein dynamic studies move to a new time slot. 
  • Protein electron transfer rates set by the bridging secondary and tertiary structure. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Protein imperfections: separating intrinsic from extrinsic variation of torsion angles. 
  • Protein kinases of malaria parasites: an update. 
  • Protein loop closure using orientational restraints from NMR data. 
  • Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data. 
  • Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. 
  • Protein-Protein Docking Benchmark 2.0: an update. 
  • Protein-protein docking: overview and performance analysis. 
  • Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin. 
  • Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit. 
  • Psychedelic-inspired drug discovery using an engineered biosensor. 
  • Pulsed EPR studies of nonexchangeable protons near the Mo(V) center of sulfite oxidase: direct detection of the alpha-proton of the coordinated cysteinyl residue and structural implications for the active site. 
  • Purification and assembly of FtsZ. 
  • Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor. 
  • Purification and characterization of frog alpha-macroglobulin: receptor recognition of an amphibian glycoprotein. 
  • Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography. 
  • Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas. 
  • Purification of kinesin-related protein complexes from eggs and embryos. 
  • Quantifying kinetic paths of protein folding. 
  • Quantifying the kinetic paths of flexible biomolecular recognition. 
  • Quantum mechanics simulation of protein dynamics on long timescale. 
  • RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. 
  • Radical Breakthroughs in Natural Product and Cofactor Biosynthesis. 
  • Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments. 
  • Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. 
  • Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY. 
  • Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. 
  • Reaction mechanisms of mononuclear non-heme iron oxygenases. 
  • Reaction path of protein farnesyltransferase at atomic resolution. 
  • Recent developments in biased agonism. 
  • Receptor biophysics and biochemistry. Enzymes. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Recognition and processing of randomly fluctuating electric signals by Na,K-ATPase. 
  • Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. 
  • Recommendations of the wwPDB NMR Validation Task Force. 
  • Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. 
  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. 
  • Regression analysis of multiple protein structures. 
  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. 
  • Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. 
  • Regulation of leukocyte migration by L-selectin: mechanisms, domains and ligands. 
  • Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane. 
  • Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism. 
  • Regulation of thrombin activity--pharmacologic and structural aspects. 
  • Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate. 
  • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. 
  • Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. 
  • Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. 
  • Residual dipolar coupling derived orientational constraints on ligand geometry in a 53 kDa protein-ligand complex. 
  • Residual dipolar couplings: synergy between NMR and structural genomics. 
  • Resolving the molecular structure of microtubules under physiological conditions with scanning force microscopy. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 2. Fe4S4 cluster vibrational modes. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. 
  • Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • Ribosome-independent regulation of translocon composition and Sec61alpha conformation. 
  • Role of Conformational Fluctuations of Protein toward Methylation in DNA by Cytosine-5-methyltransferase. 
  • Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. 
  • Role of citrate and phosphate anions in the mechanism of iron(III) sequestration by ferric binding protein: kinetic studies of the formation of the holoprotein of wild-type FbpA and its engineered mutants. 
  • Role of granulocyte collagenase in collagen degradation. 
  • Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. 
  • Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. 
  • Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. 
  • Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants. 
  • Schematic drawings of protein structures. 
  • Scientific benchmarks for guiding macromolecular energy function improvement. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Septin assemblies form by diffusion-driven annealing on membranes. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 
  • Seven-transmembrane-spanning receptors and heart function. 
  • Shapes of antibody binding sites: qualitative and quantitative analyses based on a geomorphic classification scheme. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. 
  • Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure. 
  • Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. 
  • Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. 
  • Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase. 
  • Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. 
  • Site-directed mutagenesis of the inhibitory subunit of retinal rod cyclic GMP phosphodiesterase. 
  • Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. 
  • SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. 
  • Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Specific peptide probes for G-protein interaction with effectors. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Springs and hinges: dynamic coiled coils and discontinuities. 
  • Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. 
  • Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic. 
  • Stabilization of μ-opioid receptor facilitates its cellular translocation and signaling. 
  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. 
  • Statistical characterization of protein ensembles. 
  • Statistical prediction and molecular dynamics simulation. 
  • Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins. 
  • Stoichiometries of protein-protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry. 
  • Straight and curved conformations of FtsZ are regulated by GTP hydrolysis. 
  • Streptavidin-biotin binding energetics. 
  • Stretching fibronectin. 
  • Stretching single molecules into novel conformations using the atomic force microscope. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural analysis of a human glial variant laminin. 
  • Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold. 
  • Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. 
  • Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. 
  • Structural and dynamic analysis of residual dipolar coupling data for proteins. 
  • Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. 
  • Structural and functional studies of cyclic GMP phosphodiesterase. 
  • Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. 
  • Structural and mechanical study of a self-assembling protein nanotube. 
  • Structural and mechanistic studies of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli. 
  • Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon. 
  • Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody. 
  • Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease. 
  • Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. 
  • Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1. 
  • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. 
  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. 
  • Structural basis for the differential regulation of DNA by the methionine repressor MetJ. 
  • Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. 
  • Structural basis of DNA-protein recognition. 
  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. 
  • Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. 
  • Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. 
  • Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. 
  • Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex. 
  • Structural basis of pilus subunit recognition by the PapD chaperone. 
  • Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. 
  • Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. 
  • Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC. 
  • Structural biology of plasmid segregation proteins. 
  • Structural biology: Aerial view of the HIV genome. 
  • Structural characterization of a molybdopterin precursor. 
  • Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. 
  • Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. 
  • Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection. 
  • Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain. 
  • Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. 
  • Structural insights into inhibition of lipid I production in bacterial cell wall synthesis. 
  • Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3. 
  • Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. 
  • Structural mapping of aspartate transcarbamoylase by fluorescence energy-transfer measurements: determination of the distance between catalytic sites of different subunits. 
  • Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group. 
  • Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. 
  • Structural mechanisms of QacR induction and multidrug recognition. 
  • Structural model of human ceruloplasmin based on internal triplication, hydrophilic/hydrophobic character, and secondary structure of domains. 
  • Structural organization and chromosomal assignment of the parvalbumin gene. 
  • Structural organization and regulation of the chicken estrogen receptor. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structural properties of an active form of rabbit muscle phosphofructokinase. 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin. 
  • Structural studies of Klenow fragment: an enzyme with two active sites. 
  • Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. 
  • Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. 
  • Structural studies of the heme domain of sulfite oxidase: CNBr fragments. 
  • Structural variants in SNCA gene and the implication to synucleinopathies. 
  • Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants. 
  • Structure and Affinity of Cu(I) Bound to Human Serum Albumin. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and activities of Escherichia coli DNA gyrase. 
  • Structure and dynamics of an extended conjugated NLO chromophore within an amphiphilic 4-helix bundle peptide by molecular dynamics simulation. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure and function of cholera toxin and hormone receptors. 
  • Structure and function of the CD7 molecule. 
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. 
  • Structure and mechanism of copper, zinc superoxide dismutase. 
  • Structure and mechanism of the G protein-coupled receptor kinases. 
  • Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. 
  • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. 
  • Structure of DNA polymerase I Klenow fragment bound to duplex DNA. 
  • Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. 
  • Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. 
  • Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. 
  • Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH. 
  • Structure of human Niemann-Pick C1 protein. 
  • Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy. 
  • Structure of oxidative- and photo-phosphorylation coupling factor complexes. 
  • Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. 
  • Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. 
  • Structure of the Trypanosoma brucei p22 protein, a cytochrome oxidase subunit II-specific RNA-editing accessory factor. 
  • Structure of the adrenergic and related receptors. 
  • Structure of the cytochrome c oxidase dimer. Electron microscopy of two-dimensional crystals. 
  • Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. 
  • Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation. 
  • Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. 
  • Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin. 
  • Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography. 
  • Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy. 
  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation. 
  • Structure, inhibition, and regulation of essential lipid A enzymes. 
  • Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies. 
  • Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. 
  • Structure-function relationships of the complement regulatory protein, CD59. 
  • Structure-guided reprogramming of serine recombinase DNA sequence specificity. 
  • Structures and mechanisms of DNA restriction and modification enzymes. 
  • Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. 
  • Structures of Bacterial MraY and Human GPT Provide Insights into Rational Antibiotic Design. 
  • Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. 
  • Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. 
  • Structures of ParB bound to DNA reveal mechanism of partition complex formation. 
  • Structures of human ENT1 in complex with adenosine reuptake inhibitors. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. 
  • Structures of yeast vesicle trafficking proteins. 
  • Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein. 
  • Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans. 
  • Substructure of human von Willebrand factor. 
  • Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains. 
  • Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex. 
  • Subunit dissociation and unfolding of rabbit muscle phosphofructokinase by guanidine by hydrochloride. 
  • Subunit stoichiometry and molecular weight of the pyruvate dehydrogenase multienzyme complex from Escherichia coli. 
  • Subunit structure of fragment D from fibrinogen and cross-linked fibrin. 
  • Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. 
  • Superoxidized states of Escherichia coli sulfite reductase heme protein subunit. 
  • Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Supramolecular peptide vaccines: tuning adaptive immunity. 
  • Surface structure of human mucin using X-ray photoelectron spectroscopy. 
  • Symmetry of the inhibitory unit of human alpha 2-macroglobulin. 
  • Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. 
  • Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition. 
  • Systematic solution to homo-oligomeric structures determined by NMR. 
  • T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. 
  • TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death. 
  • TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. 
  • TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity. 
  • Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. 
  • Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. 
  • Tau induces formation of α-synuclein filaments with distinct molecular conformations. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. 
  • Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The 2.0 A crystal structure of a heterotrimeric G protein. 
  • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. 
  • The C-terminal linker of Escherichia coli FtsZ functions as an intrinsically disordered peptide. 
  • The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation. 
  • The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. 
  • The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. 
  • The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization. 
  • The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans. 
  • The Mechanism of HdeA Unfolding and Chaperone Activation. 
  • The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. 
  • The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. 
  • The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism. 
  • The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. 
  • The adrenergic receptors. 
  • The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. 
  • The anatomy and taxonomy of protein structure. 
  • The aquaporin sidedness revisited. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. 
  • The beta bulge: a common small unit of nonrepetitive protein structure. 
  • The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. 
  • The clash in titin. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The compact conformation of fibronectin is determined by intramolecular ionic interactions. 
  • The conformation-dependent interaction of alpha 2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha 2-macroglobulin/growth factor binding. 
  • The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. 
  • The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. 
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. 
  • The de novo design of protein structures. 
  • The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. 
  • The disulfide bonding pattern in ficolin multimers. 
  • The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. 
  • The effect of divalent cations on the conformation and function of human plasminogen. 
  • The effect of membrane filtration upon protein conformation. 
  • The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen. 
  • The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels. 
  • The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles. 
  • The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. 
  • The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. 
  • The helix-turn-helix DNA binding motif. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human keratin genes and their differential expression. 
  • The importance of residue-level filtering and the Top2018 best-parts dataset of high-quality protein residues. 
  • The insecticidal potential of scorpion beta-toxins. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The interleukin 1 receptor. 
  • The mammalian beta-adrenergic receptors. 
  • The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O). 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. 
  • The nature of aqueous tunneling pathways between electron-transfer proteins. 
  • The nicotinamide adenine dinucleotides as allosteric effectors of human hemoglobin. 
  • The nuclear DEK interactome supports multi-functionality. 
  • The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. 
  • The other 90% of the protein: assessment beyond the Calphas for CASP8 template-based and high-accuracy models. 
  • The penultimate rotamer library. 
  • The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI. 
  • The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1. 
  • The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment. 
  • The protein surface is a moving target. 
  • The rational design and construction of a cuboidal iron-sulfur protein. 
  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. 
  • The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. 
  • The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex. 
  • The role of the third beta strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012. 
  • The second-largest subunit of the poxvirus RNA polymerase is similar to the corresponding subunits of procaryotic and eucaryotic RNA polymerases. 
  • The sequence of the reovirus serotype 3 L3 genome segment which encodes the major core protein lambda 1. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • The singly-wound parallel beta barrel: a proposed structure for 2-keto-3-deoxy-6-phosphogluconate aldolase. 
  • The site of the redox-linked proton pump in eukaryotic cytochrome c oxidases. 
  • The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. 
  • The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers. 
  • The statistical conformation of a highly flexible protein: small-angle X-ray scattering of S. aureus protein A. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. 
  • The structure and function of pyruvate kinase. 
  • The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage. 
  • The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. 
  • The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. 
  • The tyrosine corner: a feature of most Greek key beta-barrel proteins. 
  • The unique DEK oncoprotein in women's health: A potential novel biomarker. 
  • The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. 
  • Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands. 
  • Thermodynamic characterization of the osmolyte- and ligand-folded states of Bacillus subtilis ribonuclease P protein. 
  • Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. 
  • Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. 
  • Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase. 
  • Three dimensional structure of erabutoxin b neurotoxic protein: inhibitor of acetylcholine receptor. 
  • Three-dimensional structure of calmodulin. 
  • Three-dimensional structures of C-phycocyanin and B-phycoerythrin at 5-A resolution. 
  • Thrombomodulin increases the rate of thrombin inhibition by BPTI. 
  • Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. 
  • Topography of a flexible ribonucleoprotein helix: protein-protein contacts in Sendai virus nucleocapsids. 
  • Topology of an amiloride-binding protein. 
  • Topology of cell adhesion molecules. 
  • Topology of the yeast plasma membrane proton-translocating ATPase. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Total reconstitution of copper-zinc superoxide dismutase. 
  • Toward a Molecular Basis of Cellular Nucleoside Transport in Humans. 
  • Transduction of receptor signals by beta-arrestins. 
  • Trends for isolated amino acids and dipeptides: Conformation, divalent ion binding, and remarkable similarity of binding to calcium and lead. 
  • Trinodular structure of fibrinogen. Confirmation by both shadowing and negative stain electron microscopy. 
  • Tropomyosin. Does resolution lead to reconciliation? 
  • Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains. 
  • Tubulin rings: curved filaments with limited flexibility and two modes of association. 
  • Turning off the signal: desensitization of beta-adrenergic receptor function. 
  • Turnip yellow mosaic virus as a chemoaddressable bionanoparticle. 
  • Two oligomeric forms of plasma ficolin have differential lectin activity. 
  • Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. 
  • Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens. 
  • Two-dimensional crystallization and projection structure of KcsA potassium channel. 
  • Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 
  • Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. 
  • Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. 
  • Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. 
  • Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). 
  • Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. 
  • Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. 
  • Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
  • VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. 
  • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. 
  • Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site. 
  • Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. 
  • Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings. 
  • Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. 
  • Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • Visualizing conformation transitions of the Lipid II flippase MurJ. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase. 
  • When is a transcription factor a NAP? 
  • X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. 
  • X-ray crystallographic studies of streptavidin mutants binding to biotin. 
  • XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. 
  • ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. 
  • beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • beta-Sheet topology and the relatedness of proteins. 
  • cAMP receptor and G-protein interactions control development in Dictyostelium. 
  • cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. 
  • epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • pH-dependent conformational change of gastric mucin leads to sol-gel transition. 
  • Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. 
  • β-Arrestin-mediated receptor trafficking and signal transduction. 
  • β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability. 
  • μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology