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Subject Areas on Research
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5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
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5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.
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80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.
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A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia.
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A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase.
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A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.
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A potential second messenger role for arachidonic acid: activation of Ca2+-dependent protein kinase.
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A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase.
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A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.
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A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint.
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
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A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.
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A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes.
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A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.
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AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex.
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Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
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Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.
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Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.
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Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
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Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
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Activation of protein kinase C inhibits human keratinocyte migration.
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Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.
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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
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Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain.
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Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
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Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
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Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.
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Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
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Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome.
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Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
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Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
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Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway.
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Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C.
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Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes.
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Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
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Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.
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Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
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Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.
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Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
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Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
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Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers.
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Biochemical changes in leukocytes in response to chemoattractants.
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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.
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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
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Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
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CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages.
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Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells.
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Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.
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Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.
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Characterization and distribution of protein kinase C isoforms in human skin fibroblasts.
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Characterization of PDK2 activity against protein kinase B gamma.
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Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.
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Chemoattractant receptor-induced phosphorylation of L-selectin.
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Chemoattractant receptors on phagocytic cells.
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Chemoattractant-induced activation of c-fos gene expression in human monocytes.
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Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction.
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Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.
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Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model.
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Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
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Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase.
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Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse.
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Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation.
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Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation.
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Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
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Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.
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DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
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Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.
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Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
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Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.
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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.
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Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).
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Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.
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Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.
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Differential activity of protein kinase C in alveolar and peritoneal macrophages.
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Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex.
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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
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Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
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Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation.
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Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.
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Direct regulation of the Na,K pump by signal transduction mechanisms.
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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
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Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
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Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity.
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Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking.
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Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats.
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Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart.
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Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat.
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Effect of receptor number on desensitization of the mouse thromboxane receptor.
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Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
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Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.
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Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.
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Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.
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Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation.
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Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium.
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FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system?
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Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
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Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture.
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Functional divergences of PKC isoforms in the human myometrium?
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Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex.
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G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.
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G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.
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Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.
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HIV envelope gp120 activates human arterial smooth muscle cells.
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HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.
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Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
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Human leukemia cell lines with comparable receptor binding characteristics but different phenotypic responses to phorbol diesters.
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Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
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Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells.
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IL-1 receptors: structure and signals.
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Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
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Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.
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Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence.
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Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
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Identification of high-affinity calmodulin-binding proteins in rat liver.
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Immunolocalization of PKC zeta in rat photoreceptor inner segments.
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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
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Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
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Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
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Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.
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Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation.
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Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E.
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Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C.
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Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
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Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization.
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Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C.
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Intracellular signaling in primary sensory neurons and persistent pain.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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Leukocyte chemoattraction by 1,2-diacylglycerol.
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Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages.
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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
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Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
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Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
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Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system.
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Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
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Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
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Magnesium sulfate induces translocation of protein kinase C isoenzymes alpha and delta in myometrial cells from pregnant women.
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Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
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Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor.
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Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases.
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Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions.
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Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes.
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Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells.
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Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression.
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Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment.
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Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.
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Myogenic constriction of human coronary arterioles.
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Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
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Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits.
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Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model.
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Neurobehavioral teratogenicity of sarin in an avian model.
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Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line.
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New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
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New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.
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Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital.
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Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.
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Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
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Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.
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Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons.
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Pharmacology of pertussis toxin B-oligomer.
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Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes.
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Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors.
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Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
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Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices.
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Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices.
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Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
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Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.
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Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.
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Phosphorylation of Gz in human platelets. Selectivity and site of modification.
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Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein.
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Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
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Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.
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Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties.
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Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
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Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia.
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Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
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Primary structure and domain organization of human alpha and beta adducin.
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Programmed cell death induced by ceramide.
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Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation.
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Protein kinase C activates the renal apical membrane Na+/H+ exchanger.
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Protein kinase C activity, translocation, and conventional isoforms in aging rat brain.
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Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells.
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Protein kinase C beta II specifically binds to and is activated by F-actin.
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Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
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Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses.
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Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Protein kinase C isoenzymes: regulation and function.
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Protein kinase C isoforms in human aortic smooth muscle cells.
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Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium.
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Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus.
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Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro.
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Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes.
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Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies.
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Protein kinase C zeta is associated with the mitotic apparatus in primary cell cultures of the shark rectal gland.
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Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
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Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation.
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Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.
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Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.
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Protein kinase C: cellular target of the second messenger arachidonic acid?
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Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
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Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
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Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma.
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RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
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Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells.
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Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.
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Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.
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Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
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Receptor-mediated modulation of human monocyte, neutrophil, lymphocyte, and platelet function by phorbol diesters.
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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
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Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression.
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Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst.
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Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.
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Regulation of NFkappaB in hepatic ischemic preconditioning.
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Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
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Regulation of adrenergic receptor function by phosphorylation.
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Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.
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Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
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Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.
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Regulation of cation channels in liver cells by intracellular calcium and protein kinase C.
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Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons.
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Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
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Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes.
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Regulation of protein kinase C and role in cancer biology.
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Regulation of protein kinase C in NG108-15 cell differentiation.
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Regulation of protein kinases by pseudosubstrate prototopes.
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Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases.
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Regulation of the renal Na+-H+ exchanger.
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Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress.
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Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity.
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Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
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Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor.
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Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications.
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Ruboxistaurin.
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Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.
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Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
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Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing.
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Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
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Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
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Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.
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Signal transduction in cells following binding of chemoattractants to membrane receptors.
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Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes.
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Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling.
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Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.
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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
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Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats.
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Specific receptors for phorbol diesters on freshly isolated human myeloid and lymphoid leukemia cells: comparable binding characteristics despite different cellular responses.
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Specific role for protein kinase C beta in cell differentiation.
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Spinal activation of protein kinase C elicits phrenic motor facilitation.
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Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
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Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle.
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Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
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Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
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T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
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T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.
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Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.
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Targeting slow-proliferating ovarian cancer cells.
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Testosterone selectively influences protein kinase-C-coupled secretion of proluteinizing hormone-releasing hormone-derived peptides.
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Thapsigargin demonstrates calcium-dependent regulation of phosphate uptake in HeLa cells.
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The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.
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The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
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The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
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The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion.
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The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C.
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The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.
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The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures.
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The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.
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The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis.
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The role of protein kinase C in modulation of aqueous humor outflow facility.
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The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane.
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Thromboxane binding and signal transduction in rat glomerular mesangial cells.
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Tissue and cellular distribution of the extended family of protein kinase C isoenzymes.
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Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
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Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
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Transplantation of full-thickness retina in the rhodopsin transgenic pig.
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Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms.
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Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro.
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Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population.
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Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats.
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VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
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Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.
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alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Pharmacology & Cancer Biology
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Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology