Protein Kinase C

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  Subject Areas on Research

  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. 
  • 80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c. 
  • A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion. 
  • A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density. 
  • A phorbol ester-binding protein is required downstream of Rab5 in endosome fusion. 
  • A potential second messenger role for arachidonic acid: activation of Ca2+-dependent protein kinase. 
  • A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint. 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression. 
  • A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes. 
  • A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. 
  • AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex. 
  • Aberrant planar cell polarity induced by urinary tract obstruction. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS. 
  • Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. 
  • Activation of protein kinase C inhibits human keratinocyte migration. 
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. 
  • Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats. 
  • Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. 
  • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells. 
  • Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. 
  • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. 
  • Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. 
  • Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. 
  • Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • Biochemical changes in leukocytes in response to chemoattractants. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. 
  • Calcium- and zinc-binding proteins in intracellular transport. 
  • Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. 
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. 
  • Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats. 
  • Characterization and distribution of protein kinase C isoforms in human skin fibroblasts. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells. 
  • Chemoattractant receptor-induced phosphorylation of L-selectin. 
  • Chemoattractant receptors on phagocytic cells. 
  • Chemoattractant-induced activation of c-fos gene expression in human monocytes. 
  • Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Components of the protein kinase C pathway induce Ia expression after injection into macrophages. 
  • Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. 
  • Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. 
  • Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. 
  • Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). 
  • Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. 
  • Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. 
  • Differential activity of protein kinase C in alveolar and peritoneal macrophages. 
  • Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. 
  • Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation. 
  • Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols. 
  • Direct regulation of the Na,K pump by signal transduction mechanisms. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. 
  • Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. 
  • Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats. 
  • Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart. 
  • Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat. 
  • Effect of receptor number on desensitization of the mouse thromboxane receptor. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Enhanced activity and level of protein kinase A in the spinal cord supernatant of diisopropyl phosphorofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. 
  • Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium. 
  • FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system? 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. 
  • Functional divergences of PKC isoforms in the human myometrium? 
  • Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. 
  • G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta. 
  • G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. 
  • Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. 
  • Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. 
  • HIV envelope gp120 activates human arterial smooth muscle cells. 
  • HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts. 
  • Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. 
  • Human leukemia cell lines with comparable receptor binding characteristics but different phenotypic responses to phorbol diesters. 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. 
  • IL-1 receptors: structure and signals. 
  • Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse. 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. 
  • Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein). 
  • Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes. 
  • Identification of high-affinity calmodulin-binding proteins in rat liver. 
  • Immunolocalization of PKC zeta in rat photoreceptor inner segments. 
  • Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. 
  • Increased renal dopamine and acute renal adaptation to a high-phosphate diet. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity. 
  • Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor. 
  • Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. 
  • Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation. 
  • Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. 
  • Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. 
  • Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. 
  • Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons. 
  • Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization. 
  • Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C. 
  • Intracellular signaling in primary sensory neurons and persistent pain. 
  • Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors. 
  • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. 
  • Kinase and phosphatase activities intimately associated with a reconstituted calcium-dependent potassium channel. 
  • Leukocyte chemoattraction by 1,2-diacylglycerol. 
  • Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system. 
  • Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. 
  • Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. 
  • Magnesium sulfate induces translocation of protein kinase C isoenzymes alpha and delta in myometrial cells from pregnant women. 
  • Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. 
  • Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor. 
  • Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. 
  • Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes. 
  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. 
  • Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression. 
  • Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment. 
  • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. 
  • Myogenic constriction of human coronary arterioles. 
  • Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. 
  • Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. 
  • New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. 
  • Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. 
  • PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Pharmacology of pertussis toxin B-oligomer. 
  • Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. 
  • Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors. 
  • Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation. 
  • Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion. 
  • Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices. 
  • Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices. 
  • Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. 
  • Phospholipase D in TCR-Mediated Signaling and T Cell Activation. 
  • Phosphorylation and desensitization of neurokinin-1 receptor expressed in epithelial cells. 
  • Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex. 
  • Phosphorylation of Gz in human platelets. Selectivity and site of modification. 
  • Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein. 
  • Phosphorylation of the cystic fibrosis transmembrane conductance regulator. 
  • Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. 
  • Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. 
  • Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. 
  • Polymyxin B causes coordinate inhibition of phorbol ester-induced C-kinase activity and proliferation of B lymphocytes. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Programmed cell death induced by ceramide. 
  • Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation. 
  • Prostratin antagonizes HIV latency by activating NF-kappaB. 
  • Protein kinase C (calcium/phospholipid-dependent protein kinase) in developing chick heart: selective localization to atrium versus ventricle and changes in activity levels during cardiogenesis. 
  • Protein kinase C activates the renal apical membrane Na+/H+ exchanger. 
  • Protein kinase C activity, translocation, and conventional isoforms in aging rat brain. 
  • Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells. 
  • Protein kinase C beta II specifically binds to and is activated by F-actin. 
  • Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. 
  • Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses. 
  • Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Protein kinase C isoenzymes: regulation and function. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium. 
  • Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. 
  • Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro. 
  • Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Protein kinase C zeta is associated with the mitotic apparatus in primary cell cultures of the shark rectal gland. 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation. 
  • Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. 
  • Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. 
  • Protein kinase C: cellular target of the second messenger arachidonic acid? 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. 
  • Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. 
  • Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. 
  • Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. 
  • Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. 
  • Receptor-mediated modulation of human monocyte, neutrophil, lymphocyte, and platelet function by phorbol diesters. 
  • Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. 
  • Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression. 
  • Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Regulation of NFkappaB in hepatic ischemic preconditioning. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of adrenergic receptor function by phosphorylation. 
  • Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. 
  • Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. 
  • Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of endothelin-induced Ca2+ mobilization in smooth muscle cells by protein kinase C. 
  • Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. 
  • Regulation of protein kinase C and role in cancer biology. 
  • Regulation of protein kinase C in NG108-15 cell differentiation. 
  • Regulation of protein kinases by pseudosubstrate prototopes. 
  • Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. 
  • Regulation of synaptic vesicle fusion by protein kinase C. 
  • Regulation of the renal Na+-H+ exchanger. 
  • Relationship of tri-O-cresyl phosphate-induced delayed neurotoxicity to enhancement of in vitro phosphorylation of hen brain and spinal cord proteins. 
  • Repeated NMDA receptor activation induces distinct intracellular calcium changes in subpopulations of striatal neurons in vitro. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of protein kinase C (PKC) in mediating Ca2+ entry in vascular smooth muscle cells. 
  • Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. 
  • Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications. 
  • Ruboxistaurin. 
  • Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. 
  • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. 
  • Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. 
  • Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. 
  • Signal transduction in cells following binding of chemoattractants to membrane receptors. 
  • Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. 
  • Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. 
  • Specific receptors for phorbol diesters on freshly isolated human myeloid and lymphoid leukemia cells: comparable binding characteristics despite different cellular responses. 
  • Specific role for protein kinase C beta in cell differentiation. 
  • Spinal activation of protein kinase C elicits phrenic motor facilitation. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle. 
  • Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synthesis of intracellular histamine in platelets is associated with activation of protein kinase C, but not with mobilization of Ca2+. 
  • Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • Targeting slow-proliferating ovarian cancer cells. 
  • Testosterone selectively influences protein kinase-C-coupled secretion of proluteinizing hormone-releasing hormone-derived peptides. 
  • Thapsigargin demonstrates calcium-dependent regulation of phosphate uptake in HeLa cells. 
  • The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. 
  • The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line. 
  • The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. 
  • The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. 
  • The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. 
  • The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. 
  • Thromboxane binding and signal transduction in rat glomerular mesangial cells. 
  • Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. 
  • Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. 
  • Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin. 
  • Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
  • Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function. 
  • Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. 
  • UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. 
  • Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. 
  • alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s). 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • Middleton, John Paul, Associate Professor of Medicine, Medicine, Nephrology