Protein Processing, Post-Translational
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Subject Areas on Research
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A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
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A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.
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A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.
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A Flick of the Tail Keeps the Circadian Clock in Line.
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A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.
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A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine.
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A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C.
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A role for Rac3 GTPase in the regulation of autophagy.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.
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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
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ARID1A-mutated ovarian cancers depend on HDAC6 activity.
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ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells.
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Ablation of Sirtuin5
in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
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Acetylation goes global: the emergence of acetylation biology.
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Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.
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Adrenergic receptors.
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AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway.
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AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein.
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Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event.
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Alterations of fibrinogen structure in human disease.
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Altered expression of pp60c-src induced by peripheral nerve injury.
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Altered posttranslational modifications of collagen in keloid.
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An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.
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An overview of naturally occurring histone deacetylase inhibitors.
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Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
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Antigen receptor control of methionine metabolism in T cells.
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Application of immobilized ATP to the study of NLRP inflammasomes.
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Assay for protein modification by poly-ADP-ribose in vitro.
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Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate.
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Assembly and disassembly of DNA polymerase holoenzyme.
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BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.
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BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.
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Baculovirus expression of functional P210 BCR-ABL oncogene product.
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Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.
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Beta-arrestins: multifunctional cellular mediators.
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Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.
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Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C).
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Biosynthesis of renin: multiplicity of active and intermediate forms.
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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
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C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
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CD28 costimulatory signal induces protein arginine methylation in T cells.
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CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell-cycle arrest?
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CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
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Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
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Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2.
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Cellular functions of metallo-endoproteinases.
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Cellular mechanisms controlling caspase activation and function.
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Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.
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Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
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Characterization of avian and viral p60src proteins expressed in yeast.
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Characterization of canine intestinal cholecystokinin-58 lacking its carboxyl-terminal nonapeptide. Evidence for similar post-translational processing in brain and gut.
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Chemically induced proximity in biology and medicine.
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Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
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Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
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Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts.
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Combined antibody-high-performance liquid chromatography approach to assess prohormone processing.
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Coming together at the hinges: Therapeutic prospects of IgG3.
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Commitment to cell death is signaled by the appearance of a terminin protein of 30 kDa.
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Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.
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Connecting genetic risk to disease end points through the human blood plasma proteome.
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Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms.
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Control of RhoA methylation by carboxylesterase I.
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DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen.
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DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.
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DNA damage induces phosphorylation of the amino terminus of p53.
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DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
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Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.
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Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.
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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
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Detection of protein S-nitrosylation with the biotin-switch technique.
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Development of human protein reference database as an initial platform for approaching systems biology in humans.
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.
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Different routes to the same ending: comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea.
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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
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Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E.
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Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
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Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.
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Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.
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Discovering the landscape of protein modifications.
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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
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Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.
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Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
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Dynamic Opposition of Histone Modifications.
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Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.
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Editing the Epigenome: Reshaping the Genomic Landscape.
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Electron capture dissociation mass spectrometry in characterization of post-translational modifications.
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Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
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Engineering soluble major histocompatibility molecules: why and how.
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Enzymatic modification of proteins with a geranylgeranyl isoprenoid.
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Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.
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Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection.
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Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
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Epigenetics and cancer metabolism.
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Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.
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Ethanol metabolism modifies hepatic protein acylation in mice.
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Evidence against posttranslational glycosylation of rat glucocorticoid receptors.
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Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation.
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Evolution. CNCing is believing.
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Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
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Expression and modification of Hox 2.1 protein in mouse embryos.
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Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperature.
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
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FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.
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Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans
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Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus.
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From promiscuity to precision: protein phosphatases get a makeover.
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Functional regulation of Wnt protein through post-translational modifications.
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Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
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Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications.
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Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
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G proteins. Visual differences.
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Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis.
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Genetically Encoded Cholesterol-Modified Polypeptides.
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Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.
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Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1.
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Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
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Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.
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Glycosylation influences intracellular transit time and secretion rate of human prorenin in transfected cells.
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
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HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.
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HDACs in skeletal muscle remodeling and neuromuscular disease.
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HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression.
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HPLC enrichment/isolation of proteins for post-translational modification studies from complex mixtures.
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High-mobility group box-1 isoforms as potential therapeutic targets in sepsis.
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Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
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Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
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Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.
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Human interleukin-2 production in insect (Trichoplusia ni) larvae: effects and partial control of proteolysis.
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Human renin biosynthesis and secretion in normal and ischemic kidneys.
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IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
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Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.
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Identification of deacetylase substrates with the biotin switch approach.
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Identification of mitochondrial cytochrome P450 induced in response to polycyclic aromatic hydrocarbons in the mummichog (Fundulus heteroclitus).
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Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology.
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In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.
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In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
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In vivo post-translational processing and subunit reconstitution of cephalosporin acylase from Pseudomonas sp. 130.
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Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
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Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.
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Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
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Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
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Integrated proteomics and metabolomics suggests symbiotic metabolism and multimodal regulation in a fungal-endobacterial system.
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Intracellular cleavage of an SSV coded gag-related protein.
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Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells.
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Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling.
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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
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Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin.
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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
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Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling.
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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
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Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
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Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.
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Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.
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K63 polyubiquitination is a new modulator of the oxidative stress response.
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KDM1 class flavin-dependent protein lysine demethylases.
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Keratinocyte urokinase-type plasminogen activator is secreted as a single chain precursor.
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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
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LW protein: a promiscuous integrin receptor activated by adrenergic signaling.
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Lefty proteins exhibit unique processing and activate the MAPK pathway.
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Life, death, and the metabolically controlled protein acetylome.
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Lipid modifications of G proteins.
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Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons.
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Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.
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Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase.
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Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.
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Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
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Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.
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Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
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LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
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Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
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Lysine modifications and autophagy.
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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
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Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.
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Mechanisms of MAVS regulation at the mitochondrial membrane.
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Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.
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Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.
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Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).
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Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
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Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners.
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Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
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Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones.
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Mitochondrial DNA-depleted A549 cells are resistant to bleomycin.
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Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
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Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
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Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis.
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Molecular studies of human renin structure and synthesis using monoclonal antibodies.
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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
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N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier.
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N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
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NOS2 regulation of NF-kappaB by S-nitrosylation of p65.
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Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation.
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Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
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Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein.
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Neurotrophins: transcription and translation.
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Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.
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New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans.
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NgBR is essential for endothelial cell glycosylation and vascular development.
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Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.
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Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine.
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Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
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Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.
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Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis.
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Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.
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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
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O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.
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Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
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Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.
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Orchidectomy induces temporal and regional changes in the synthesis and processing of the LHRH prohormone in the rat brain.
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Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.
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Oxidatively modified proteins as plasma biomarkers in breast cancer.
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PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.
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Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
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Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
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Phosphatases driving mitosis: pushing the gas and lifting the brakes.
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Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity.
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Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.
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Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
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Phosphorylation of Nox1 regulates association with NoxA1 activation domain.
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Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
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Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis.
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Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
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Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.
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Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498.
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Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.
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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.
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Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
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Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways.
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Post-illumination cellular effects of photodynamic treatment.
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Post-prenylation-processing enzymes as new targets in oncogenesis.
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Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.
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Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
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Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.
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Post-translational modifications regulate the ticking of the circadian clock.
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Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.
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Post-translational regulation of plant immunity.
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Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology.
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Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
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Posttranslational modifications of tubulin in teleost photoreceptor cytoskeletons.
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Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence.
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Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
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Pro-GnRH processing.
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Processing of one-chain to two-chain renin in the mouse submandibular gland is influenced by androgen.
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Processing of the luteinizing hormone-releasing hormone precursor in the preoptic area and hypothalamus of the rat.
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Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.
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Protein S-nitrosylation: purview and parameters.
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Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.
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Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation.
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Protein modification by deamidation indicates variations in joint extracellular matrix turnover.
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Protein prenylation: unique fats make their mark on biology.
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Protein serine/threonine phosphatases--new avenues for cell regulation.
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Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
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Proteolytic degradation of von Willebrand factor after DDAVP administration in normal individuals.
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Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.
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Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.
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Proteomic analysis of the luteal endometrial secretome.
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Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.
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Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid.
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RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
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RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.
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RIP3: a molecular switch for necrosis and inflammation.
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ROCK1 phosphorylates and activates zipper-interacting protein kinase.
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Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
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Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
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Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.
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Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.
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Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.
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Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.
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Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein.
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Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers.
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Regulating the regulator: NF-kappaB signaling in heart.
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Regulation of cholecystokinin synthesis and secretion in rat intestine.
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Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons.
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Regulation of topoisomerase II by phosphorylation: a role for casein kinase II.
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Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
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Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.
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Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer.
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Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity.
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Resonating to the music of ubiquitination.
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Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
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Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element.
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Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress.
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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
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Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.
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S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.
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S-nitrosylation in the regulation of gene transcription.
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SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.
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STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.
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SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ.
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Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function.
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Sensing and integration of Erk and PI3K signals by Myc.
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Septin phosphorylation and coiled-coil domains function in cell and septin ring morphology in the filamentous fungus Ashbya gossypii.
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Seven-transmembrane receptors and ubiquitination.
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Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice.
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Signal integration and gene induction by a functionally distinct STAT3 phosphoform.
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Simple biochemical pathways far from steady state can provide switchlike and integrated responses.
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Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.
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Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress.
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Site-specific analysis of protein S-acylation by resin-assisted capture.
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Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton.
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Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry.
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Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
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Structural basis for impaired 5' processing of a mutant tRNA associated with defects in neuronal homeostasis.
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Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model.
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Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens.
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Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
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Sweet modification and regulation of death receptor signalling pathway.
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T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.
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T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.
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TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44.
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Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides.
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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
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Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.
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The 2.0 A crystal structure of a heterotrimeric G protein.
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The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation.
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The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.
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The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation.
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The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
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The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.
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The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
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The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.
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The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
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The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
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The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
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The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
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The discovery of histone deacetylase.
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The extra fragment of the iron-sulfur protein (residues 96-107) of Rhodobacter sphaeroides cytochrome bc1 complex is required for protein stability.
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The g-value paradox.
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The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: a clinicopathological study of 262 cases.
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The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
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The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
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The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.
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The regulation of DNA topoisomerase II by casein kinase II.
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The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
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The role of Gla proteins in vascular calcification.
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The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases.
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The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia.
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The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.
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The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation.
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The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
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Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.
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Three periods of regulatory innovation during vertebrate evolution.
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Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.
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Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells.
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Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure.
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Topoisomerase II: its functions and phosphorylation.
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Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.
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Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.
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TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts.
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TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.
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Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.
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Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity.
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Ubiquitination and filamentous structure of cytidine triphosphate synthase.
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Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.
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Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
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Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
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Use of protein phosphatase inhibitors.
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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
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Wnt addiction of genetically defined cancers reversed by PORCN inhibition.
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XIAP as target for therapeutic apoptosis in prostate cancer.
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Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.
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Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury.
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[LMP-420, a new therapeutic approach for cerebral malaria?].
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eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
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β-Arrestin-mediated receptor trafficking and signal transduction.
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β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
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β-arrestin-biased signaling by the β-adrenergic receptors.
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βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Shinohara, Mari L.,
Professor of Integrative Immunobiology,
Cell Biology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Integrative Immunobiology
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Wray, Gregory Allan,
Professor of Biology,
Evolutionary Anthropology
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Zennadi, Rahima,
Associate Professor in Medicine,
Pathology