Protein Synthesis Inhibitors

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  Subject Areas on Research

  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. 
  • A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. 
  • Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells. 
  • Aluminum is a weak agonist for the calcium-sensing receptor. 
  • Apoptosis is the mode of cell death caused by carcinogenic chromium. 
  • Characterization of mesonephric development and regeneration using transgenic zebrafish. 
  • Clarithromycin treatment for Mycobacterium avium-intracellulare complex lung disease. 
  • Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. 
  • Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. 
  • Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Halofuginone inhibits collagen deposition in fibrous capsules around implants. 
  • Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium. 
  • Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages. 
  • O6-benzylguanine-mediated enhancement of chemotherapy. 
  • Ontogenetic differences in energy metabolism and inhibition of protein synthesis in hippocampal slices during in vitro ischemia and 24 h of recovery. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • P-glycoprotein involvement in cuticular penetration of [14C]thiodicarb in resistant tobacco budworms. 
  • Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Rapid arrest of axon elongation by brefeldin A: a role for the small GTP-binding protein ARF in neuronal growth cones. 
  • Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. 
  • Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. 
  • Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1. 
  • Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. 
  • Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposure. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. 
  • TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. 
  • Tedizolid (TR-701): a new oxazolidinone with enhanced potency. 
  • Telithromycin. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. 
  • The extracellular release of HMGB1 during apoptotic cell death. 
  • The role of protein synthesis in striatal long-term depression. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Toxoplasmic encephalitis associated with meningitis in a heart transplant recipient. 
  • Two serologic markers to monitor the engraftment, growth, and treatment response of human leukemias in severe combined immunodeficient mice. 
  • mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. 
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  Keywords of People

  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology