Protein-Tyrosine Kinases

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  Subject Areas on Research

  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. 
  • A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. 
  • A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. 
  • A positive addition to a negative tail's tale. 
  • A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258). 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. 
  • A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor. 
  • ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase". 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. 
  • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling. 
  • Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. 
  • Activation of MAP kinase by a dual specificity Tyr/Thr kinase. 
  • Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies. 
  • Activation of protein kinase C inhibits human keratinocyte migration. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Activation of tyrosine kinases in cancer. 
  • Advances in the understanding and treatment of human severe combined immunodeficiency. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Anti-epidermal growth factor receptor therapy for glioblastoma in adults. 
  • Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antiseizure effects of TrkB kinase inhibition. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways. 
  • Assessing inheritance of agammaglobulinemia. 
  • Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability. 
  • Association of the polyomavirus middle-T antigen with c-yes protein. 
  • Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • Atypical X-linked agammaglobulinemia. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. 
  • Baculovirus expression of functional P210 BCR-ABL oncogene product. 
  • Barriers to Prescribing Targeted Therapies for Patients With NSCLC With Highly Actionable Gene Variants in the Veterans Affairs National Precision Oncology Program. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. 
  • Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers. 
  • Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase. 
  • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Cell biology. Propelling progeny. 
  • Cellular targeting in autoimmunity. 
  • Characterization of avian and viral p60src proteins expressed in yeast. 
  • Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. 
  • Chronic myelogenous leukemia, version 1.2015. 
  • Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review. 
  • Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred. 
  • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. 
  • Combination antiangiogenic tyrosine kinase inhibition and anti-PD1 immunotherapy in metastatic renal cell carcinoma: A retrospective analysis of safety, tolerance, and clinical outcomes. 
  • Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Cost-Effectiveness of Tumor Genomic Profiling to Guide First-Line Targeted Therapy Selection in Patients With Metastatic Lung Adenocarcinoma. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Cytoplasmic localization of the transforming protein of Fujinami sarcoma virus: salt-sensitive association with subcellular components. 
  • DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. 
  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. 
  • Detection of the JAK2 V617F mutation by LightCycler PCR and probe dissociation analysis. 
  • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. 
  • Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. 
  • Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor. 
  • Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. 
  • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. 
  • Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. 
  • Dose-response characteristics of neonatal exposure to genistein on pituitary responsiveness to gonadotropin releasing hormone and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postpubertal castrated female rats. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. 
  • Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. 
  • Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. 
  • Expression of polyoma early gene products in E. coli. 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. 
  • Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. 
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. 
  • Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. 
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. 
  • Giant two-dimensional gel electrophoresis: methodological update and comparison with intermediate-format gel systems. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • Heart hypertrophy during pregnancy: a better functioning heart? 
  • Heart regeneration in zebrafish. 
  • Heritable resistance to tyrosine kinase inhibitors. 
  • Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. 
  • Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. 
  • Identifying Blood-Based Protein Biomarkers for Antiangiogenic Agents in the Clinic: A Decade of Progress. 
  • Improving frontline treatment for chronic myeloid leukemia: emerging evidence for use of nilotinib and dasatinib. 
  • In Reply. 
  • Induction of T cell CD7 gene transcription by nonmitogenic ionomycin-induced transmembrane calcium flux. 
  • Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells. 
  • Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. 
  • Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf. 
  • Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. 
  • Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth. 
  • Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. 
  • Interplay between septin organization, cell cycle and cell shape in yeast. 
  • Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling. 
  • Intrinsically determined cell death of developing cortical interneurons. 
  • Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. 
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. 
  • Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes. 
  • JAK2 is required for induction of the murine DUB-1 gene. 
  • Jak3 and the pathogenesis of severe combined immunodeficiency. 
  • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia. 
  • Ligation of the alpha2M signalling receptor elevates the levels of p21Ras-GTP in macrophages. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. 
  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. 
  • Mammalian and Drosophila blood: JAK of all trades? 
  • Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. 
  • Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. 
  • MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma. 
  • Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion. 
  • Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. 
  • Molecular and functional signature of heart hypertrophy during pregnancy. 
  • Molecular dissection of lymphocyte signal transduction pathways. 
  • Molecular markers for incidence, prognosis, and response to therapy. 
  • Molecular signaling mechanisms underlying epileptogenesis. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification. 
  • Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding. 
  • Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. 
  • Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. 
  • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. 
  • Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. 
  • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Novel therapies for pancreatic adenocarcinoma. 
  • Novel therapies for pancreatic adenocarcinoma. 
  • Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. 
  • Nuclear tyrosine kinases: from Abl to WEE1. 
  • Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. 
  • Oncogenes in ovarian cancer. 
  • Ordered phosphorylation of p42mapk by MAP kinase kinase. 
  • Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma. 
  • Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. 
  • Overview consensus statement. Newer approaches to androgen deprivation therapy in prostate cancer. 
  • Overview of protein phosphorylation. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. 
  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation. 
  • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. 
  • Phase II trial of gefitinib in recurrent glioblastoma. 
  • Phosphatidylinositol kinase type I activity associates with various oncogene products. 
  • Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3. 
  • Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. 
  • Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. 
  • Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Platelet-derived growth factor receptors: a therapeutic target in solid tumors. 
  • Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. 
  • Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines. 
  • Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation. 
  • Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent. 
  • Protein lipidation in cell signaling. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions. 
  • Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. 
  • Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. 
  • Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. 
  • ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer. 
  • RTK and TGF-beta signaling pathways genes in the sea urchin genome. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. 
  • Receptor tyrosine kinases as rational targets for prostate cancer treatment: platelet-derived growth factor receptor and imatinib mesylate. 
  • Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of NFkappaB in hepatic ischemic preconditioning. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. 
  • Regulation of apoptosis in Xenopus egg extracts. 
  • Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. 
  • Regulation of protein kinases by pseudosubstrate prototopes. 
  • Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45. 
  • Regulation of tyrosine kinase cascades by G-protein-coupled receptors. 
  • Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase. 
  • Rendering the leukemia cell susceptible to attack. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. 
  • Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA. 
  • Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies. 
  • Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of the ABL oncogene tyrosine kinase activity in human leukaemia. 
  • SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • SU5416 delays wound healing through inhibition of TGF-beta 1 activation. 
  • Serum levels of HER-2 neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer. 
  • Seven-transmembrane receptor signaling through beta-arrestin. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. 
  • Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177). 
  • Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. 
  • Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. 
  • Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. 
  • Studies on the adapter molecule LAT. 
  • Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. 
  • T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T-lymphoblastic lymphoma and acute myeloid leukaemia transformed from myeloid neoplasm with eosinophilia: a divergent evolution of myeloid neoplasm with monosomy 7 but no detectable tyrosine kinase gene rearrangements designated by the WHO Classification. 
  • TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. 
  • TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. 
  • Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials. 
  • Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. 
  • The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. 
  • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. 
  • The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases. 
  • The Ephrin B2 Receptor Tyrosine Kinase Is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett's Neoplasia. 
  • The Evolving Landscape of Frontline Therapy in Chronic Phase Chronic Myeloid Leukemia (CML). 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. 
  • The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials. 
  • The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion. 
  • The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. 
  • The clash in titin. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. 
  • The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. 
  • The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. 
  • The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. 
  • The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase. 
  • The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. 
  • The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons. 
  • The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. 
  • Tie2 (to) Abl: Signaling to endothelial cell survival. 
  • Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Transduction of receptor signals by beta-arrestins. 
  • Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. 
  • TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. 
  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Tyrosine phosphorylation in human neutrophil. 
  • Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 
  • Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity. 
  • Wnt pathway activation: new relations and locations. 
  • Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. 
  • beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology