Proteins

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  Subject Areas on Research

  • (Session Introduction) Joint Learning from Multiple Types of Genomic Data 
  • 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. 
  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. 
  • 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. 
  • A 'just-in-time' HN(CA)CO experiment for the backbone assignment of large proteins with high sensitivity. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. 
  • A Hausdorff-based NOE assignment algorithm using protein backbone determined from residual dipolar couplings and rotamer patterns. 
  • A New Lens for RNA Localization: Liquid-Liquid Phase Separation. 
  • A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. 
  • A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma. 
  • A Prob(e)able Route to Lysine Acylation. 
  • A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. 
  • A clinical review of nutritional support of the patient. 
  • A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. 
  • A colloidal Au monolayer modulates the conformation and orientation of a protein at the electrode/solution interface. 
  • A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A conserved sorting-associated protein is mutant in chorea-acanthocytosis. 
  • A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice. 
  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • A functional proteomics approach to signal transduction. 
  • A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in the snc1 mutant 
  • A general and efficient cantilever functionalization technique for AFM molecular recognition studies. 
  • A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution. 
  • A gradient-directed Monte Carlo approach for protein design. 
  • A gradient-directed Monte Carlo method for global optimization in a discrete space: application to protein sequence design and folding. 
  • A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. 
  • A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers. 
  • A hot-vent gastropod with iron sulfide dermal sclerites. 
  • A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors. 
  • A kinetic study of protein-protein interactions. 
  • A machine learning approach for the prediction of protein surface loop flexibility. 
  • A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. 
  • A nanoscale force probe for gauging intermolecular interactions. 
  • A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. 
  • A new generation of crystallographic validation tools for the protein data bank. 
  • A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. 
  • A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins. 
  • A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes. 
  • A novel intracellular protein delivery platform based on single-protein nanocapsules 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. 
  • A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A protein microarray-based analysis of S-nitrosylation. 
  • A rat liver 57-kDa protein is identified to share antigenic determinants with statin, a marker for nonproliferating cells. 
  • A robotics platform for automated batch fabrication of high density, microfluidics-based DNA microarrays, with applications to single cell, multiplex assays of secreted proteins. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins. 
  • A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. 
  • A statistical thermodynamic model of the protein ensemble. 
  • A stochastic evolutionary model for protein structure alignment and phylogeny. 
  • A strategy for the rapid identification of phosphorylation sites in the phosphoproteome. 
  • A test of enhancing model accuracy in high-throughput crystallography. 
  • A topological data analytic approach for discovering biophysical signatures in protein dynamics. 
  • A variant in FTO shows association with melanoma risk not due to BMI. 
  • A zebrafish model for the Shwachman-Diamond syndrome (SDS). 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • AFM-Based Single-Molecule Force Spectroscopy of Proteins. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. 
  • Aberrant promoter methylation of multiple genes in non-small cell lung cancers. 
  • Abnormal Fhit expression in malignant and premalignant lesions of the cervix. 
  • Absence of three secreted proteins and presence of a 57-kDa protein related to irreversible arrest of cell growth. 
  • Accentuation of differentially expressed proteins using phage technology. 
  • Accuracy of SUPREX (stability of unpurified proteins from rates of H/D exchange) and MALDI mass spectrometry-derived protein unfolding free energies determined under non-EX2 exchange conditions. 
  • Acetylation goes global: the emergence of acetylation biology. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. 
  • Activation of transducin guanosine triphosphatase by two proteins of the RGS family. 
  • Active learning for computational chemogenomics. 
  • Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics? 
  • Adaptor proteins in lymphocyte activation. 
  • Adding Dynamic Biomolecule Signaling to Hydrogel Systems via Tethered Photolabile Cell-Adhesive Proteins. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Adhesin presentation in bacteria requires molecular chaperones and ushers. 
  • Adhesion mediated by bonds in series. 
  • Adhesion properties of catechol-based biodegradable amino acid-based poly(ester urea) copolymers inspired from mussel proteins. 
  • Adiponectin is not altered with exercise training despite enhanced insulin action. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Advances, interactions, and future developments in the CNS, Phenix, and Rosetta structural biology software systems. 
  • Advantage of the Mark-III FEL for biophysical research and biomedical applications. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Algorithm for backrub motions in protein design. 
  • Algorithm selection for protein-ligand docking: strategies and analysis on ACE. 
  • All-atom contacts: a new approach to structure validation. 
  • Alpha 2-macroglobulin: a sensor for proteolysis. 
  • Alpha-crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation. 
  • Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma. 
  • Alternate states of proteins revealed by detailed energy landscape mapping. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 
  • An algorithm for smoothly tessellating beta-sheet structures in proteins. 
  • An automated decision-tree approach to predicting protein interaction hot spots. 
  • An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants. 
  • An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • An immunological induced defect of neuromuscular transmission in rats. 
  • An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An interview with Jane Richardson. 
  • An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Analysis of experimental time-resolved crystallographic data by singular value decomposition. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Analysis of protein folding and function using backbone modified proteins. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides. 
  • Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. 
  • Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. 
  • Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data. 
  • Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. 
  • Another cystic mystery solved. 
  • Antennal hair erection in male mosquitoes: a new mechanical effector in insects. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. 
  • Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner. 
  • Are all nonproliferating cells similar? 
  • Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors. 
  • Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences. 
  • Asparagine and glutamine rotamers: B-factor cutoff and correction of amide flips yield distinct clustering. 
  • Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation. 
  • Assessment of detailed conformations suggests strategies for improving cryoEM models: Helix at lower resolution, ensembles, pre-refinement fixups, and validation at multi-residue length scale. 
  • Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. 
  • Atropine enhances food-stimulated CCK secretion in the rat. 
  • Autodegradation of 125I-labeled human epidermal cell surface proteins. 
  • Autofix for backward-fit sidechains: using MolProbity and real-space refinement to put misfits in their place. 
  • Automated identification of protein-ligand interaction features using Inductive Logic Programming: a hexose binding case study. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Away from the edge II: in-house Se-SAS phasing with chromium radiation. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • BBK* (Branch and Bound Over K*): A Provable and Efficient Ensemble-Based Protein Design Algorithm to Optimize Stability and Binding Affinity Over Large Sequence Spaces. 
  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. 
  • BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. 
  • BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. 
  • BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. 
  • Barnacle Balanus amphitrite adheres by a stepwise cementing process. 
  • Barnacle cement: a polymerization model based on evolutionary concepts. 
  • Basic matrices for the matrix-assisted laser desorption/ionization mass spectrometry of proteins and oligonucleotides. 
  • Bayesian inference for genomic data integration reduces misclassification rate in predicting protein-protein interactions. 
  • Bayesian segmentation of protein secondary structure. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. 
  • Beyond the E-Value: Stratified Statistics for Protein Domain Prediction. 
  • BioWarehouse: a bioinformatics database warehouse toolkit. 
  • Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF). 
  • Biochemical changes in rat testis during postnatal maturation. 
  • Biochemical determinants of growth sparing during neonatal nutritional deprivation or enhancement: ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart. 
  • Biochemical development of the rat lung: studies on cellular DNA, RNA and protein content in relation to maternal vitamin A status. 
  • Biochemical mass spectrometry: worth the weight? 
  • Biochemistry of protein prenylation. 
  • Bioinformatic challenges in targeted proteomics. 
  • Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. 
  • Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C. 
  • Biophysical highlights from 54 years of macromolecular crystallography. 
  • Biophysics of knotting. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. 
  • Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Bone morphogenetic proteins: multifunctional regulators of vertebrate development. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • Branching morphogenesis of the lung: new models for a classical problem. 
  • Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding. 
  • Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. 
  • CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • Ca2+ regulation of sperm axonemal motility. 
  • Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin. 
  • Calorimetric evaluation of protein-carbohydrate affinities. 
  • Can Dissipative Properties of Single Molecules Be Extracted from a Force Spectroscopy Experiment? 
  • Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes. 
  • Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition. 
  • Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione. 
  • Cartilage matrix remodelling differs by disease state and joint type. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Caspase cleavage is not for everyone. 
  • Cathepsin D of rabbit skin: an immunoenzymic study. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Cell culture block array for immunocytochemical study of protein expression in cultured cells. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell interactions and endoderm differentiation in cultured mouse embryos. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Cellular uptake and photodynamic activity of protein nanocages containing methylene blue photosensitizing drug. 
  • Cerebrospinal fluid atrial natriuretic factor in intracranial disease. 
  • Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice. 
  • Changes in the lung after prolonged positive pressure ventilation in normal baboons. 
  • Chaperone-assisted assembly and molecular architecture of adhesive pili. 
  • Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin. 
  • Characterization of 57 kDa statin as a true marker for growth arrest in tissue by its disappearance from regenerating liver. 
  • Characterization of COMMD protein-protein interactions in NF-kappaB signalling. 
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells. 
  • Characterization of XIAP-deficient mice. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of human Gadd45, a p53-regulated protein. 
  • Characterization of implantable biosensor membrane biofouling. 
  • Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B. 
  • Characterization of neuronal protein phosphatases in Aplysia californica. 
  • Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. 
  • Characterization of the statin-like S1 and rat elongation factor 1 alpha as two distinctly expressed messages in rat. 
  • Characterization of two populations of statin and the relationship of their syntheses to the state of cell proliferation. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Chemical Denaturation and Protein Precipitation Approach for Discovery and Quantitation of Protein-Drug Interactions. 
  • Chemical evidence for early but unsustained growth in the obstructed mouse kidney. 
  • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene. 
  • Chemically Orthogonal Protein Ligation Domains for Independent Control of Hydrogel Modification with Adhesive Ligands and Growth Factors. 
  • Chemically induced proximity in biology and medicine. 
  • Chemistry. Nanomaterials for drug delivery. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. 
  • Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. 
  • Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. 
  • Cilia proteins are biomarkers of altered flow in the vasculature. 
  • Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. 
  • Clinical benefits of pegylated proteins in oncology. 
  • Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. 
  • Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge. 
  • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. 
  • Comparative analysis reveals distinctive epigenetic features of the human cerebellum. 
  • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Competition between monomeric and dimeric crystals in schematic models for globular proteins. 
  • Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. 
  • Computational advances in combating colloidal aggregation in drug discovery. 
  • Computational crystallization. 
  • Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore. 
  • Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. 
  • Computing van der Waals energies in the context of the rotamer approximation. 
  • Concentration and desalting of protein samples for mass spectrometry analysis. 
  • Concerning the hormonal regulation of androgen binding protein in rat testis. 
  • Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. 
  • Connecting protein family resources using the proWeb network. 
  • Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Continuous Interdomain Orientation Distributions Reveal Components of Binding Thermodynamics. 
  • Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. 
  • Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Correlation of serologic and urinary tests with allograft biopsy in the diagnosis of pancreas rejection. 
  • Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. 
  • Covalent protein-oligonucleotide conjugates by copper-free click reaction. 
  • Creativity comes from interactions: modules of protein interactions in plants. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer. 
  • Crustacean peptide and peptide-like pheromones and kairomones. 
  • Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge. 
  • Cryo-electron microscopy--a primer for the non-microscopist. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Crystallization of asymmetric patchy models for globular proteins in solution 
  • Crystallographic model validation: from diagnosis to healing. 
  • Current trends in differential expression proteomics: isotopically coded tags. 
  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. 
  • Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility. 
  • Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate. 
  • DIG--a system for gene annotation and functional discovery. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells. 
  • DNA: wire or insulator? 
  • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. 
  • Dating branches on the tree of life using DNA. 
  • De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. 
  • De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence. 
  • Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. 
  • Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. 
  • Defusing redox bombs? 
  • Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. 
  • Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. 
  • Describing patterns of protein tertiary structure. 
  • Design and application of a data-independent precursor and product ion repository. 
  • Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies. 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Determinants of increased energy expenditure in HIV-infected women. 
  • Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation. 
  • Development of the lipid-rich core in human atherosclerosis. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? 
  • Developmental pattern of DNA and proteins in brain, liver, lung and heart of rats given excess vitamin A postnatally. 
  • Developmental pattern of the hepatic DNA, RNA and protein in relation to maternal vitamin A status in rats. 
  • Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver. 
  • Developmentally regulated expression of two members of the Nrarp family in zebrafish. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Dietary protein requirements and body protein metabolism in endurance-trained men. 
  • Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. 
  • Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. 
  • Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA. 
  • Direct antidiabetic effect of leptin through triglyceride depletion of tissues. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. 
  • Disappearance of statin, a protein marker for non-proliferating and senescent cells, following serum-stimulated cell cycle entry. 
  • Discovering the landscape of protein modifications. 
  • Discovery of protein- and DNA-imperceptible nanoparticle hard coating using gel-based reaction tuning. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins. 
  • Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage? 
  • Doing molecular biophysics: finding, naming, and picturing signal within complexity. 
  • Domain-oriented edge-based alignment of protein interaction networks. 
  • Dominant kinetic paths on biomolecular binding-folding energy landscape. 
  • Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. 
  • Downhill kinetics of biomolecular interface binding: globally connected scenario. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • Early ribbon drawings of proteins. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effect of feeding plant proteins on plasma, liver, heart, aorta and brain lipids of rats. 
  • Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection. 
  • Effect of transient hydronephrosis on subsequent compensatory renal growth. 
  • Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris. 
  • Effects of environmental tobacco smoke exposure in utero and/or postnatally on brain development. 
  • Effects of p-xylene inhalation on axonal transport in the rat retinal ganglion cells. 
  • Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps. 
  • Effects of prenatal terbutaline exposure on cellular development in lung and liver of neonatal rat: ornithine decarboxylase activity and macromolecules. 
  • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. 
  • Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats. 
  • Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Electrocardiographic assessment for therapeutic proteins--scientific discussion. 
  • Electron capture dissociation mass spectrometry in characterization of peptides and proteins. 
  • Electron microscopy of MAP 2 (microtubule-associated protein 2). 
  • Electron paramagnetic resonance studies of iron reduction and semiquinone formation in metalloflavoproteins. 
  • Electron transfer mechanisms. 
  • Electron-tunneling pathways in proteins. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. 
  • Encoded multichromophore response for simultaneous label-free detection. 
  • Endocytosis proteins and cancer: a potential link? 
  • Endogenous salivary inhibitors of human immunodeficiency virus. 
  • Energetics-based methods for protein folding and stability measurements. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects. 
  • Engineering soluble major histocompatibility molecules: why and how. 
  • Enhanced protein breakdown after eccentric exercise in young and older men. 
  • Enhanced protein fold recognition through a novel data integration approach. 
  • Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. 
  • Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control 
  • Epigenetic detection of human chromosome 14 uniparental disomy. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. 
  • Evaluating the quality of NMR structures by local density of protons. 
  • Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. 
  • Evaluation of peritoneal fluid following intestinal resection and anastomosis in horses. 
  • Everolimus tablets for patients with subependymal giant cell astrocytoma. 
  • Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence of juxtacrine signaling for transforming growth factor alpha in human endometrium. 
  • Evolution. CNCing is believing. 
  • Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees. 
  • Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites. 
  • Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. 
  • Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay. 
  • Exercise and nutritional needs of elderly people: effects on muscle and bone. 
  • Exercise and protein metabolism. 
  • Exomes, Proteins, and Cardiovascular Disease: Making Sense of the Signals. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. 
  • Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium. 
  • Expression of genes for non-collagenous proteins during embryonic bone formation. 
  • Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Expression of proliferation-specific genes in the mucosa adjacent to colon carcinoma. 
  • Expression of statin, a non-proliferation-dependent nuclear protein, in the postnatal rat brain: evidence for substantial retention of neuroglial proliferative capacity with aging. 
  • Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. 
  • FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. 
  • FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism. 
  • FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. 
  • FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 
  • Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. 
  • False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. 
  • Familial variable expression of dilated cardiomyopathy in Alström syndrome: a report of four sibs. 
  • Fast and forceful refolding of stretched alpha-helical solenoid proteins. 
  • Fat hormones pull their weight in the CNS. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Femtomolar sensitivity using a channel-etched thin film waveguide fluoroimmunosensor. 
  • Fetal dexamethasone exposure impairs cellular development in neonatal rat heart and kidney: effects on DNA and protein in whole tissues. 
  • Fibrillar peptide gels in biotechnology and biomedicine. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart. 
  • Filtered backprojection for the reconstruction of a high-resolution (4,2)D CH3-NH NOESY spectrum on a 29 kDa protein. 
  • Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. 
  • Flow cytometric analysis of fluorescence resonance energy transfer: a tool for high-throughput screening of molecular interactions in living cells. 
  • Fluctuations in biological and bioinspired electron-transfer reactions. 
  • Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope. 
  • Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions. 
  • Found in translation: applications of protein and peptide molecular diversity. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. 
  • Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes. 
  • From the RNA world to the clinic. 
  • Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. 
  • Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter. 
  • Functional and structural characterization of endosomes from toad bladder epithelial cells. 
  • Functional bionetworks from nanoliter water droplets. 
  • Further evidence for the involvement of EFL1 in a Shwachman-Diamond-like syndrome and expansion of the phenotypic features. 
  • Further investigation of simian immunodeficiency virus Vif function in human cells. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. 
  • Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases 
  • Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. 
  • Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. 
  • Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • Genetic mechanisms that determine oxidative capacity of striated muscles. Control of gene transcription. 
  • Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. 
  • Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. 
  • Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. 
  • Giant two-dimensional gel electrophoresis: methodological update and comparison with intermediate-format gel systems. 
  • Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein. 
  • Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis. 
  • Glutathione depletion in epithelial lining fluid of lung allograft patients. 
  • Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis. 
  • Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. 
  • Growth factors in development: the role of TGF-beta related polypeptide signalling molecules in embryogenesis. 
  • H/D exchange and mass spectrometry-based method for biophysical analysis of multidomain proteins at the domain level. 
  • H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. 
  • HASH: a program to accurately predict protein Hα shifts from neighboring backbone shifts. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HPLC enrichment/isolation of proteins for post-translational modification studies from complex mixtures. 
  • Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. 
  • Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts. 
  • Hepatic mitochondrial membrane lipid environment and protein nutrition. 
  • Hexabrachion proteins in embryonic chicken tissues and human tumors. 
  • Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. 
  • Hierarchy of RNA functional dynamics. 
  • High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5α-Restrictive Macaques. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High-level 2H/13C/15N labeling of proteins for NMR studies. 
  • High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations. 
  • High-throughput identification of IMCD proteins using LC-MS/MS. 
  • High-throughput screening assay for the tunable selection of protein ligands. 
  • Highly photostable fluorescent labeling of proteins in live cells using exchangeable coiled coils heterodimerization. 
  • Histamine stimulates calcium-mediated protein phosphorylation in a colonic epithelial cell line. 
  • Histochemical localization of Statin--a non-proliferation-specific nuclear protein--in nuclei of normal and abnormal human thyroid tissue. 
  • Homogeneous NMR spectra in inhomogeneous fields. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human RPE expression of cell survival factors. 
  • Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. 
  • Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. 
  • Huntington's-chorea fibroblasts. Cellular protein glycosylation. 
  • Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. 
  • IAP proteins: blocking the road to death's door. 
  • IAP proteins: sticking it to Smac. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors. 
  • Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of a novel gene linked to parkin via a bi-directional promoter. 
  • Identification of casein kinase I substrates by in vitro expression cloning screening. 
  • Identification of cis-suppression of human disease mutations by comparative genomics. 
  • Identification of deacetylase substrates with the biotin switch approach. 
  • Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase. 
  • Identification of novel murine- and human-specific RPGRIP1 splice variants with distinct expression profiles and subcellular localization. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. 
  • Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. 
  • Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy. 
  • Immunohistochemical analysis of statin in colorectal adenocarcinoma, polyps, and normal mucosa. 
  • Immunoinhibition of intracellular protein digestion in macrophages. 
  • Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones. 
  • Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome. 
  • Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • Improved AlphaFold modeling with implicit experimental information. 
  • Improved chemistry restraints for crystallographic refinement by integrating the Amber force field into Phenix. 
  • Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299. 
  • In vitro characterization of microdialysis sampling of macromolecules. 
  • In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. 
  • Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. 
  • Incorporating Nearest-Neighbor Site Dependence into Protein Evolution Models. 
  • Incorporation of non-proteolytic proteins by murine alpha2-macroglobulin. 
  • Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. 
  • Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. 
  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA. 
  • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. 
  • Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2. 
  • Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. 
  • Influence of ATM function on telomere metabolism. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. 
  • Inhibitor-1, a regulator of protein phosphatase 1 function. 
  • Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide. 
  • Initial sequencing and analysis of the human genome. 
  • Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. 
  • Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanisms. 
  • Insights into domain-domain motions in proteins and RNA from solution NMR. 
  • Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. 
  • Integrating statistical pair potentials into protein complex prediction. 
  • Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA. 
  • Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. 
  • Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. 
  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Introduction: protein motifs. 
  • Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms. 
  • Investigation of noncalcium interactions of fura-2 by classical and synchronous fluorescence spectroscopy. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. 
  • Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. 
  • Ionic liquid-assisted PDMS microchannel modification for efficiently resolving fluorescent dye and protein adsorption. 
  • Ionic liquids as selectors for the enhanced detection of proteins. 
  • Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. 
  • Is it better to combine predictions? 
  • Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Isolation of a cDNA clone complementary to sequences for a 34-kilodalton protein which is a pp60v-src substrate. 
  • Isolation of highly purified, functional endosomes from toad urinary bladder. 
  • Isolation of protein factors from oviduct polysomes which stimulate protein synthesis. 
  • Isoproterenol downregulation of statin-related gene expression in the rat parotid gland. 
  • Iterative in situ click chemistry creates antibody-like protein-capture agents. 
  • Kinemages--simple macromolecular graphics for interactive teaching and publication. 
  • Kinetics of protein-protein association explained by Brownian dynamics computer simulation. 
  • LAB: a new membrane-associated adaptor molecule in B cell activation. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • LMP2 expression and proteasome activity in NOD mice. 
  • Label free colorimetric biosensing using nanoparticles. 
  • Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate. 
  • Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. 
  • Leptin directly alters lipid partitioning in skeletal muscle. 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. 
  • Leptin regulates proinflammatory immune responses. 
  • Lessons from Yeast on How to Avoid Stress Eating. 
  • Leucine metabolism during fasting and exercise. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution. 
  • Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. 
  • Linkage and association with type 1 diabetes on chromosome 1q42. 
  • Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Liposomal delivery of soluble protein antigens for class I MHC-mediated antigen presentation. 
  • Long-term healing of bone using recombinant human bone morphogenetic protein 2. 
  • Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. 
  • Long-term protein and calorie restriction: alterations in nucleic acid levels of organs of male rats. 
  • Longitudinal mechanical tension induces growth in the small bowel of juvenile rats. 
  • Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration. 
  • MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes. 
  • Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Making Biological Sense of GWAS Data: Lessons from the FTO Locus. 
  • Mapping hole hopping escape routes in proteins. 
  • Mapping the proteo-genomic convergence of human diseases. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Mass spectrometry as a readout of protein structure and function. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Matching isotopic distributions from metabolically labeled samples. 
  • Maternal vitamin A restriction alters biochemical development of the brain in rats. 
  • Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques. 
  • Measurements of protein stability by H/D exchange and matrix-assisted laser desorption/ionization mass spectrometry using picomoles of material. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism of fast protein folding. 
  • Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha 2-macroglobulin. 
  • Mechanisms for the testicular hypertrophy which follows hemicastration. 
  • Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard. 
  • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. 
  • Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor. 
  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. 
  • Metabolic activity of the lung. 
  • Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. 
  • Metaprotein expression modeling for label-free quantitative proteomics. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate. 
  • Methodologies for the characterization, identification and quantification of S-nitrosylated proteins. 
  • Micro- and nanostructured poly[oligo(ethylene glycol)methacrylate] brushes grown from photopatterned halogen initiators by atom transfer radical polymerization. 
  • Microchip micellar electrokinetic chromatography based on one functionalized ionic liquid and its excellent performance on proteins separation. 
  • Microproteomics: quantitative proteomic profiling of small numbers of laser-captured cells. 
  • Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Mixed peptide sequencing and the FASTF/FASTS algorithms. 
  • Model validation: local diagnosis, correction and when to quit. 
  • Modeling the Mechanisms by Which Coexisting Biomolecular RNA-Protein Condensates Form. 
  • Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. 
  • Modulation of nuclear statin expression in rat thyroid follicle cell following administration of thyroid stimulating hormone. 
  • Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. 
  • MolProbity: More and better reference data for improved all-atom structure validation. 
  • MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. 
  • MolProbity: all-atom structure validation for macromolecular crystallography. 
  • Molecular biologist's guide to proteomics. 
  • Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. 
  • Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. 
  • Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis. 
  • Molecular morphogens. Upside-down ideas vindicated. 
  • Molprobity's ultimate rotamer-library distributions for model validation. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Monitoring molecular interactions in living cells using flow cytometric analysis of fluorescence resonance energy transfer. 
  • Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. 
  • Montagnard ethnicity and genetic relations in northern Cameroon: comment on "The Peopling of Sub-Saharan Africa: The Case Study of Cameroon," by G. Spedini et al. 
  • Morphological and biochemical changes which occur during postnatal development and maturation of the rat testis. 
  • Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. 
  • Movement characteristics of bovine epididymal spermatozoa: effects of forward motility protein and epididymal maturation. 
  • Multidimensional NMR spectroscopy for protein characterization and assignment inside cells. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Multiscale implementation of infinite-swap replica exchange molecular dynamics. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. 
  • Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene. 
  • Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. 
  • Mutations in the TSGA14 gene in families with autism spectrum disorders. 
  • N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines. 
  • N-succinimidyl 5-(trialkylstannyl)-3-pyridinecarboxylates: a new class of reagents for protein radioiodination. 
  • NMR structures of biomolecules using field oriented media and residual dipolar couplings. 
  • Nanoscale packed-capillary liquid chromatography coupled with mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. 
  • Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17. 
  • Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • New insights into protein S-nitrosylation. Mitochondria as a model system. 
  • New tools and data for improving structures, using all-atom contacts. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. 
  • Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages. 
  • Nitrogen and nature. 
  • Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Non-chromatographic purification of recombinant elastin-like polypeptides and their fusions with peptides and proteins from Escherichia coli. 
  • Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. 
  • North, south, or east? Blotting techniques. 
  • Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker. 
  • Novel retrotransposed imprinted locus identified at human 6p25. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. 
  • OSPREY: protein design with ensembles, flexibility, and provable algorithms. 
  • OVX1 as a marker for early stage endometrial carcinoma. 
  • OVX1 radioimmunoassay complements CA-125 for predicting the presence of residual ovarian carcinoma at second-look surgical surveillance procedures. 
  • OVX1, macrophage-colony stimulating factor, and CA-125-II as tumor markers for epithelial ovarian carcinoma: a critical appraisal. 
  • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. 
  • Obtaining Soft Matter Models of Proteins and their Phase Behavior. 
  • On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. 
  • Ophthalmologic findings in Cornelia de Lange syndrome: a genotype-phenotype correlation study. 
  • Optical mapping of protein-DNA complexes on chromatin fibers. 
  • Optical nanosensors for detecting proteins and biomarkers in individual living cells. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Optimal specificity and function for flexible biomolecular recognition. 
  • Optimized mixed Markov models for motif identification. 
  • Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue. 
  • Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). 
  • Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms. 
  • Out of Eden: stem cells and their niches. 
  • Out with the old, in with the new? Comparing methods for measuring protein degradation. 
  • Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats. 
  • Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies. 
  • Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders. 
  • Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms. 
  • Overview of protein phosphorylation. 
  • Overview of protein phosphorylation. 
  • Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. 
  • Oxidative stress and covalent modification of protein with bioactive aldehydes. 
  • PACES: Protein sequential assignment by computer-assisted exhaustive search. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. 
  • PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • PR-CALC: a program for the reconstruction of NMR spectra from projections. 
  • PSORS2 is due to mutations in CARD14. 
  • Painting proteins with covalent labels: what's in the picture? 
  • Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro. 
  • Parathyroid hormone-related protein and lung injury after pulmonary thromboendarterectomy. 
  • Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids. 
  • Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading. 
  • Pathway analysis of protein electron-transfer reactions. 
  • Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Patterns of regulation from mRNA and protein time series. 
  • Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Persistence of structure over fluctuations in biological electron-transfer reactions. 
  • Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies. 
  • Pharmacologic manipulation of ob expression in a dietary model of obesity. 
  • Phenome-wide association studies (PheWASs) for functional variants. 
  • Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. 
  • Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation. 
  • Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis. 
  • Photoacoustic imaging using genetically encoded reporters: a review. 
  • Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. 
  • Photoinitiated destruction of composite porphyrin-protein polymersomes. 
  • Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. 
  • Physiologic importance of protein phosphatase inhibitors. 
  • Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. 
  • Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. 
  • Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. 
  • Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. 
  • Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells. 
  • Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. 
  • Planar integrated optical methods for examining thin films and their surface adlayers. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Polarized transport of membrane and secreted proteins during lumen morphogenesis. 
  • Poliovirus replicase stimulation by terminal uridylyl transferase. 
  • Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. 
  • Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Predicting protein-ligand interactions based on bow-pharmacological space and Bayesian additive regression trees. 
  • Preferential formation and repair of chromium-induced DNA adducts and DNA--protein crosslinks in nuclear matrix DNA. 
  • Prenatal cocaine and cell development in rat brain regions: effects on ornithine decarboxylase and macromolecules. 
  • Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins. 
  • Presence of leptin in breast cell lines and breast tumors. 
  • Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption 
  • Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. 
  • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. 
  • Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes. 
  • Programmable DNA self-assemblies for nanoscale organization of ligands and proteins. 
  • Proliferative activity at colonic anastomoses as determined by statin. A nonproliferation-specific nuclear protein. 
  • Proliferative activity of colonic mucosa at different distances from primary adenocarcinoma as determined by the presence of statin: a nonproliferation-specific nuclear protein. 
  • Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. 
  • Promoter logic. 
  • Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation. 
  • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. 
  • Protein (serine and threonine) phosphate phosphatases. 
  • Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications. 
  • Protein S-nitrosylation in health and disease: a current perspective. 
  • Protein S-nitrosylation: purview and parameters. 
  • Protein construct storage: Bayesian variable selection and prediction with mixtures. 
  • Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins. 
  • Protein design and folding: template trapping of self-assembled helical bundles. 
  • Protein dynamic studies move to a new time slot. 
  • Protein electron transfer rates set by the bridging secondary and tertiary structure. 
  • Protein engineering and the development of generic biosensors. 
  • Protein engineering approaches to biomaterials design. 
  • Protein fabrication automation. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Protein imperfections: separating intrinsic from extrinsic variation of torsion angles. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. 
  • Protein loop closure using orientational restraints from NMR data. 
  • Protein nanotechnology: the new frontier in biosciences. 
  • Protein patterning by UV-induced photodegradation of poly(oligo(ethylene glycol) methacrylate) brushes. 
  • Protein patterning. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • Protein phosphatase regulation by endogenous inhibitors. 
  • Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway. 
  • Protein phosphorylation: hormones, drugs, and bioregulation. 
  • Protein prediction for trait mapping in diverse populations. 
  • Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents. 
  • Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data. 
  • Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins. 
  • Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. 
  • Protein- Polymer Nanoparticles for Nonviral Gene Delivery 
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 
  • Protein-polymer conjugation-moving beyond PEGylation. 
  • Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease. 
  • Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. 
  • Proteome analysis by mass spectrometry. 
  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale. 
  • Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. 
  • Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). 
  • Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. 
  • Protocol for the thermodynamic analysis of some proteins using an H/D exchange- and mass spectrometry-based technique. 
  • Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. 
  • Purification and activity study of the A- and B-chains of cinnamomin, a type II ribosome-inactivating protein. 
  • Purification and biochemical characterization of statin, a nonproliferation specific protein from rat liver. 
  • Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography. 
  • Puzzle pieces defined: locating common packing units in tertiary protein contacts. 
  • Quality & quantity of dietary protein & acute endosulphan metabolic toxicity in rat liver microsomes. 
  • Quantifying kinetic paths of protein folding. 
  • Quantifying the kinetic paths of flexible biomolecular recognition. 
  • Quantitation of protein-protein interactions by thermal stability shift analysis. 
  • Quantitative and selective fluorophore labeling of phosphoserine on peptides and proteins: characterization at the attomole level by capillary electrophoresis and laser-induced fluorescence. 
  • Quantitative protein stability measurement in vivo. 
  • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • RGS10 is a selective activator of G alpha i GTPase activity. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • RIPK3: Beyond Necroptosis. 
  • RNA conformational propensities determine cellular activity. 
  • RNA surfaces as functional mimetics of proteins. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons. 
  • Radiommunoassay of delta9-tetrahydrocannabinol. 
  • Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments. 
  • Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling. 
  • Rapid electrochemical detection on a mobile phone. 
  • Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY. 
  • Rapid separation and characterization of protein and peptide mixtures using 1.5 microns diameter non-porous silica in packed capillary liquid chromatography/mass spectrometry. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Rational protein design: combining theory and experiment. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Real-time 3D single molecule tracking. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Recent trends in protein and peptide-based biomaterials for advanced drug delivery. 
  • Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. 
  • Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. 
  • Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration. 
  • Recommendations of the wwPDB NMR Validation Task Force. 
  • Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein. 
  • Reconstitution of secretory protein translocation from detergent-solubilized rough microsomes. 
  • Reconstitution of simian virus 40 DNA replication with purified proteins. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Reg3 Proteins as Gut Hormones? Don't Be Hasty. 
  • Regulation of G protein-coupled receptor signaling by scaffold proteins. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of biliary protein secretion in dogs. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of cellular processes by S-nitrosylation. Preface. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Regulation of plasminogen activation by components of the extracellular matrix. 
  • Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. 
  • Regulation of protein synthesis by phosphorylation of ribosomal protein S6 and aminoacyl-tRNA synthetases. 
  • Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase. 
  • Regulation of sugar transport in cultured diploid human skin fibroblasts. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Relation of age-related cataract with obesity and obesity genes in an Asian population. 
  • Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies. 
  • Relevance of the Speed and Direction of Pulling in Simple Modular Proteins. 
  • Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. 
  • Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. 
  • Reproduction and survival in Mediterranean fruit flies: a "protein and energy" free radical model of aging. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. 
  • Resistance of Zwitterionic Peptide Monolayers to Biofouling. 
  • Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors. 
  • Results of NC-6300 (Nanoparticle Epirubicin) in an Expansion Cohort of Patients with Angiosarcoma. 
  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice. 
  • Revealing noncovalent interactions. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Right ventricular hypertrophy with early dysfunction: A proteomics study in a neonatal model. 
  • Role of Caspases and Gasdermin A during HSV-1 Infection in Mice. 
  • Role of leptin in fat regulation. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases. 
  • Rumenectomy-induced proliferation in duodenal villous epithelium is mechanistically related to the disappearance of statin, a non-proliferation-specific nuclear protein. 
  • Ruminococcus gnavus and Limosilactobacillus reuteri Regulate Reg3γ Expression through Multiple Pathways. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • SERS opens a new way in aptasensor for protein recognition with high sensitivity and selectivity. 
  • SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation. 
  • SV40-transformed hamster prostatic tissue: a model of human prostatic malignancy. 
  • Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of SBI-087, a CD20-Directed B-cell Depleting Agent: Phase 1 Dose Escalating Studies in Patients With Either Mild Rheumatoid Arthritis or Systemic Lupus. 
  • Schematic drawings of protein structures. 
  • Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. 
  • Sculpting proteins interactively: continual energy minimization embedded in a graphical modeling system. 
  • Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. 
  • Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. 
  • Sensitive, label-free protein assay using 1-ethyl-3-methylimidazolium tetrafluoroborate-supported microchip electrophoresis with laser-induced fluorescence detection. 
  • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 
  • Sequential changes in bulk renal protein and polyribosomes in the acutely obstructed mouse kidney. 
  • Serial dilution curve: a new method for analysis of reverse phase protein array data. 
  • Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. 
  • Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system. 
  • Signal transduction. Unexpected mediators of protein phosphorylation. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Signaling by wingless in Drosophila. 
  • Signatures of protein-DNA recognition in free DNA binding sites. 
  • Simulation of electron transfer between cytochrome C2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants. 
  • Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Single molecule mechanical manipulation for studying biological properties of proteins, DNA, and sugars. 
  • Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. 
  • Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins. 
  • Site-specific analysis of protein S-acylation by resin-assisted capture. 
  • Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean Indians: The Singapore Indian Eye Study. 
  • Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry. 
  • Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. 
  • Soft lithographic functionalization and patterning oxide-free silicon and germanium. 
  • Soft matter perspective on protein crystal assembly. 
  • Soluble alpha2-macroglobulin receptor is increased in endotracheal aspirates from infants and children after cardiopulmonary bypass. 
  • Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. 
  • Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability. 
  • Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins. 
  • Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes. 
  • Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. 
  • Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles. 
  • Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species. 
  • Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures. 
  • Statin expression associated with terminally differentiating and postreplicative lens epithelial cells. 
  • Statin expression in the untreated and SarCNU-exposed human glioma cell line, SK-MG-1. 
  • Statin immunolocalization in human brain tumors. Detection of noncycling cells using a novel marker of cell quiescence. 
  • Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state. 
  • Statin, a protein specifically present in nonproliferating cells, is a phosphoprotein and forms a complex with a 45-kilodalton serine/threonine kinase. 
  • Statin--a novel marker of nonproliferation. Expression in nonneoplastic lymphoid tissues and follicular lymphomas. 
  • Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms. 
  • Statistical characterization of protein ensembles. 
  • Statistical prediction and molecular dynamics simulation. 
  • Stem cells: A tale of two kingdoms. 
  • Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes. 
  • Stretching single molecules into novel conformations using the atomic force microscope. 
  • Stretching single polysaccharides and proteins using atomic force microscopy. 
  • Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications. 
  • Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins 
  • Structural and dynamic analysis of residual dipolar coupling data for proteins. 
  • Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. 
  • Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon. 
  • Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. 
  • Structural basis of pilus subunit recognition by the PapD chaperone. 
  • Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. 
  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation. 
  • Studies on mode of action of vitamin A. 
  • Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver- a morphological and biochemical study. 
  • Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. 
  • Studying 3D subdomains of proteins at the nanometer scale using fluorescence spectroscopy. 
  • Studying and polishing the PDB's macromolecules. 
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes. 
  • Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. 
  • Synthesis of Modular Brush Polymer-Protein Hybrids Using Diazotransfer and Copper Click Chemistry. 
  • Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F. 
  • Synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate: a radio-iodination agent for labeling internalizing proteins and peptides. 
  • Systematic solution to homo-oligomeric structures determined by NMR. 
  • TGF-beta related genes in development. 
  • TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. 
  • TSPEAR variants are primarily associated with ectodermal dysplasia and tooth agenesis but not hearing loss: A novel cohort study. 
  • Target domain definition and classification in CASP8. 
  • Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Temporal relationships of statin and terminin expression in ventral lobe of rat prostate following castration. 
  • Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy. 
  • Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. 
  • The 2012/2013 ABRF Proteomic Research Group Study: Assessing Longitudinal Intralaboratory Variability in Routine Peptide Liquid Chromatography Tandem Mass Spectrometry Analyses. 
  • The ARMS2 A69S variant and bilateral advanced age-related macular degeneration. 
  • The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation. 
  • The DVR gene family in embryonic development. 
  • The Disease and Gene Annotations (DGA): an annotation resource for human disease. 
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. 
  • The ENCODE (ENCyclopedia Of DNA Elements) Project. 
  • The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The Gene Ontology (GO) database and informatics resource. 
  • The IAP family of apoptotic regulators. 
  • The IAP proteins: caspase inhibitors and beyond. 
  • The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. 
  • The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. 
  • The Phenix software for automated determination of macromolecular structures. 
  • The RNAissance period. 
  • The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. 
  • The anatomy and taxonomy of protein structure. 
  • The backrub motion: how protein backbone shrugs when a sidechain dances. 
  • The cluster glycoside effect. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The construction of metal centers in proteins by rational design. 
  • The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. 
  • The de novo design of protein structures. 
  • The diagnosis of Plasmodium falciparum infection using a new antigen detection system. 
  • The differential expression of statin in the nuclei of human colonic crypts adjacent to a cancer: an immunohistochemical study. 
  • The differentiation process of intestinal epithelial cells is associated with the appearance of statin, a non-proliferation-specific nuclear protein. 
  • The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro. 
  • The dishevelled protein is modified by wingless signaling in Drosophila. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The effect of protein nutrition on host and tumor metabolism. 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. 
  • The end game of chemical genetics: target identification. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. 
  • The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. 
  • The genome of the sea urchin Stongylocentrotus purpuratus 
  • The high-throughput protein-to-structure pipeline at SECSG. 
  • The highways and byways of bioinorganic chemistry. 
  • The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. 
  • The human olfactory transcriptome. 
  • The impact of diet switching on resource allocation to reproduction and longevity in Mediterranean fruitflies. 
  • The importance of residue-level filtering and the Top2018 best-parts dataset of high-quality protein residues. 
  • The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The kinemage: a tool for scientific communication. 
  • The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism. 
  • The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. 
  • The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. 
  • The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 
  • The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. 
  • The organizer factors Chordin and Noggin are required for mouse forebrain development. 
  • The other 90% of the protein: assessment beyond the Calphas for CASP8 template-based and high-accuracy models. 
  • The p53-dependent gamma-ray response of GADD45. 
  • The penultimate rotamer library. 
  • The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI. 
  • The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. 
  • The protein surface is a moving target. 
  • The relationship of expression of statin, the nuclear protein of nonproliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ. 
  • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. 
  • The role of Toll-like receptor 4 in environmental airway injury in mice. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The roles of 14-3-3 proteins in signal transduction. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The simple construction of protein alpha-carbon models. 
  • The standing pool of genomic structural variation in a natural population of Mimulus guttatus. 
  • The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The study of protein mechanics with the atomic force microscope. 
  • The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu). 
  • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. 
  • Therapeutic Aptamers: Evolving to Find their Clinical Niche. 
  • Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model. 
  • Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes. 
  • Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. 
  • Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation. 
  • Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. 
  • Three-dimensional reconstruction of tubular myelin. 
  • Thrombospondin-1 is a major activator of TGF-beta1 in vivo. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Thromboxane binding and signal transduction in rat glomerular mesangial cells. 
  • Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney. 
  • Time-resolved, light scattering measurements of cartilage and cornea denaturation due to free electron laser radiation. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker. 
  • Toward Building Protein Force Fields by Residue-Based Systematic Molecular Fragmentation and Neural Network. 
  • Toxicity of expanded polyglutamine-domain proteins in Escherichia coli. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Transforming growth factor-beta signaling in cancer. 
  • Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. 
  • Transmembrane adaptor proteins: organizers of immunoreceptor signalling. 
  • Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. 
  • Treatment of human spermatozoa with seminal plasma inhibits protein tyrosine phosphorylation. 
  • Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6. 
  • Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. 
  • Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Ultrasensitive colorimetric detection of protein by aptamer-Au nanoparticles conjugates based on a dot-blot assay. 
  • Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. 
  • Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Update in podocyte biology: putting one's best foot forward. 
  • Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution. 
  • Usefulness of material recovered from distal embolic protection devices after carotid angioplasty: too little, too late? 
  • Using context to improve protein domain identification. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Vasoactive intestinal peptide stimulates protein phosphorylation in a colonic epithelial cell line. 
  • Ventricular arrhythmia in the X-linked cardiomyopathy Barth syndrome. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. 
  • Voltage-induced long-range coherent electron transfer through organic molecules. 
  • Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. 
  • Why Are DNA and Protein Electron Transfer So Different? 
  • Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. 
  • X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • XIAP as target for therapeutic apoptosis in prostate cancer. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck. 
  • XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. 
  • Zinc inhibits turnover of labile mRNAs in intact cells. 
  • Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. 
  • [THE ENZYMES OF THE LEUKOCYTE]. 
  • [Vitamin B12 and protein metabolism]. 
  • beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. 
  • beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 
  • beta-Catenin is a Nek2 substrate involved in centrosome separation. 
  • beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. 
  • cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. 
  • miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. 
  • p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
  • p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. 
  • rac, a novel ras-related family of proteins that are botulinum toxin substrates. 
  • rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bobay, Benjamin, Assistant Professor in Radiology, Radiology
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology