Chondroitin Sulfate Proteoglycans
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Subject Areas on Research
- Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
- Biaxial strain effects on cells from the inner and outer regions of the meniscus.
- CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer.
- Chondroitin sulfate glycosaminoglycans for CNS homeostasis-implications for material design.
- Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.
- Cornelia de Lange syndrome in diverse populations.
- Development and validation of a cell-based fluorescent method for measuring antibody affinity.
- Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis.
- Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.
- Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia.
- Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
- In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury.
- Increased content of chondroitin sulfate proteoglycan in human colorectal carcinoma metastases compared with the primary tumor as determined by an anti-chondroitin-sulfate monoclonal antibody.
- Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.
- Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
- Lumican and muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia.
- Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
- Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension.
- Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report.
- Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.
- Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient.
- Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies.
- Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display.
- Structural analysis of a human glial variant laminin.
- Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury.
- Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
- Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition.
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Keywords of People
- Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
- McLendon, Roger Edwin, Professor of Pathology, Pathology