Proteoglycans

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  Subject Areas on Research

  • 3D Culture Facilitates VEGF-Stimulated Endothelial Differentiation of Adipose-Derived Stem Cells. 
  • 3D traction stresses activate protease-dependent invasion of cancer cells. 
  • A common variant near TGFBR3 is associated with primary open angle glaucoma. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • ALK1 regulates the internalization of endoglin and the type III TGF-β receptor. 
  • Activities of daily living influence tibial cartilage T1rho relaxation times. 
  • An in vitro neurite-promoting antigen functions in axonal regeneration in vivo. 
  • Angiostatin's molecular mechanism: aspects of specificity and regulation elucidated. 
  • Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage. 
  • Antigen-induced arthritis. Studies on the inhibition of proteoglycan synthesis observed in articular cartilage during short-term joint inflammation. 
  • Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. 
  • Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • Basic methods in histopathology of joint tissues. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Biaxial strain effects on cells from the inner and outer regions of the meniscus. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. 
  • Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of corneal proteoglycans under vitamin A deficiency. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Cloning and developmental expression of the chick type II and type III TGF beta receptors. 
  • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. 
  • Collagen changes in rat cervix in pregnancy--polarized light microscopic and electron microscopic studies. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Control of proteoglycan synthesis. Studies on the activation of synthesis observed during culture of articular cartilages. 
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. 
  • Degradation of proteoglycan in articular cartilage. 
  • Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro. 
  • Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. 
  • Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (delta-f508) cystic fibrosis transmembrane conductance regulator. 
  • Early treatment of candidemia in adults: a review. 
  • Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion. 
  • Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. 
  • Elucidating the Molecular Composition of Cartilage by Proteomics. 
  • Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. 
  • Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. 
  • Engineering superficial zone features in tissue engineered cartilage. 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage. 
  • Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. 
  • Expression cloning and characterization of the TGF-beta type III receptor. 
  • Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta. 
  • Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells. 
  • Extracellular matrix disruption and pain after eccentric muscle action. 
  • Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. 
  • Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling. 
  • Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation. 
  • Gait Mechanics and T1ρ MRI of Tibiofemoral Cartilage 6 Months after ACL Reconstruction. 
  • Genetic polymorphisms associated with priapism in sickle cell disease. 
  • Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. 
  • Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. 
  • Genome-wide meta-analyses of smoking behaviors in African Americans. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds. 
  • In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. 
  • Increased content of chondroitin sulfate proteoglycan in human colorectal carcinoma metastases compared with the primary tumor as determined by an anti-chondroitin-sulfate monoclonal antibody. 
  • Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. 
  • Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture. 
  • Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. 
  • Length Specificity and Polymerization Mechanism of (1,3)-β-d-Glucan Synthase in Fungal Cell Wall Biosynthesis. 
  • Loss of betaglycan expression in ovarian cancer: role in motility and invasion. 
  • Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. 
  • Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. 
  • Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Mechanobiology of the meniscus. 
  • Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. 
  • MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. 
  • Monoclonal antibodies that detect biochemical markers of arthritis in humans. 
  • More than skin deep: connecting melanocyte pigmentation and angiogenic diseases. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Mouse models of diabetic nephropathy. 
  • Multicenter clinical evaluation of the (1-->3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. 
  • Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases. 
  • Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. 
  • Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology. 
  • Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. 
  • Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. 
  • Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. 
  • Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage. 
  • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. 
  • Roles for the type III TGF-beta receptor in human cancer. 
  • Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times. 
  • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. 
  • Sex- and age-specific genetic analysis of chronic back pain. 
  • Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. 
  • Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate. 
  • Structure and expression of a membrane component of the inhibin receptor system. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers. 
  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. 
  • Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration. 
  • Tenascin knockout mice: barrels, boundary molecules, and glial scars. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation. 
  • The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells. 
  • The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. 
  • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42. 
  • The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation. 
  • The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling. 
  • The type III TGF-beta receptor suppresses breast cancer progression. 
  • The type III TGFbeta receptor regulates directional migration: new tricks for an old dog. 
  • The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer. 
  • The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2. 
  • The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells. 
  • Three-dimensional direct writing of B35 neuronal cells. 
  • Tumor antigens in astrocytic gliomas. 
  • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. 
  • Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. 
  • Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth. 
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. 
  • TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling. 
  • TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. 
  • Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells. 
  • Why Do Osteochondral Allografts Survive? Comparative Analysis of Cartilage Biochemical Properties Unveils a Molecular Basis for Durability. 
  • Wnt signaling: an embarrassment of receptors. 
  • [Expression of recombinant human hemangiopoietin and preparation of its polyclonal antibody]. 
  • hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. 
  • tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hanks, Brent A., Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology