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Subject Areas on Research
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5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis.
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A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
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A cell-intrinsic role for Mst1 in regulating thymocyte egress.
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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
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A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.
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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
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A feedback loop in the polo-like kinase activation pathway.
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A genetic variant within MDM4 3'UTR miRNA binding site is associated with HPV16-positive tumors and survival of oropharyngeal cancer.
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A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
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A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
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A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.
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A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
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A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
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A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.
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A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.
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A multigene family encoding a diverse array of putative pheromone receptors in mammals.
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A new trick for Cyclin-Cdk: activation of STAT.
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A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies.
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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
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A novel protective effect of erythropoietin in the infarcted heart.
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A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2.
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A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer.
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A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.
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A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.
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A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation.
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ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
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AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
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Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.
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Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.
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Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
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Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
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Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro.
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Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
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Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
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Additive and synergistic interactions of monoclonal antibodies and immunotoxins reactive with breast and ovarian cancer.
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Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
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Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
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Age increases expression and receptor-mediated activation of G alpha i in human atria.
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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.
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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.
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Akt/protein kinase B promotes organ growth in transgenic mice.
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Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.
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Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
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Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
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Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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Analysis of DNA mismatch repair proteins in human medulloblastoma.
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Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells.
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Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185.
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Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain.
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Apoptosis and B cell tolerance.
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Apoptosis: inhibitor or instigator of carcinogenesis?
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Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.
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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
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Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Assessment of c-erbB-2 amplification by immunohistochemistry in paraffin-embedded breast cancer.
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Association between KRAS rs61764370 and triple-negative breast cancer--a false positive?
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Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study.
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Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability.
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Association of the polyomavirus middle-T antigen with c-yes protein.
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Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
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Autocrine stimulation of mas oncogene leads to altered growth control.
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Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
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BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
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BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.
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BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.
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Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.
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Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.
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Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.
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Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.
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Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
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Biomarkers predict progression of acute kidney injury after cardiac surgery.
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Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery.
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Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers.
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Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase.
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CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes.
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CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.
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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CD28 costimulatory signal induces protein arginine methylation in T cells.
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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
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CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
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Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.
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Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*.
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Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
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Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
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Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.
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Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
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Cell cycle deregulation and xeroderma pigmentosum group C cell transformation.
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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587).
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Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.
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Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse.
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Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
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Cellular mechanisms of wingless/Wnt signal transduction.
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Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas.
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Characterization of avian and viral p60src proteins expressed in yeast.
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Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial.
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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
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Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.
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Cloning and structural analysis of the human c-kit gene.
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Cocaine shapes chromatin landscapes via Tet1.
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Colon cancer, version 3.2014.
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Combined p53-related genetic variants together with HPV infection increase oral cancer risk.
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Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders.
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Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene.
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Congenital central hypoventilation syndrome: mutation analysis of the receptor tyrosine kinase RET.
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Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.
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Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.
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Conversion of Bcl-2 to a Bax-like death effector by caspases.
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Conversion of diploidy to haploidy.
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Crk is required for apoptosis in Xenopus egg extracts.
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Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
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DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes.
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DNA damage induces phosphorylation of the amino terminus of p53.
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DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7.
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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
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Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis.
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Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.
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Deletions in CCM2 are a common cause of cerebral cavernous malformations.
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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
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Detection of the JAK2 V617F mutation by LightCycler PCR and probe dissociation analysis.
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Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts.
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Differential expression of VEGF isoforms in mouse during development and in the adult.
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Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.
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Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
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Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.
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Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites.
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Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo.
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Discovery of thiophene inhibitors of polo-like kinase.
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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
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Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.
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Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells.
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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
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Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
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Does phaster mean better?
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
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Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
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EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.
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ELF3 is a repressor of androgen receptor action in prostate cancer cells.
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ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
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Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
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Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.
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Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat.
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Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture.
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Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.
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Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
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Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
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Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
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Emerging concepts in acute kidney injury following cardiac surgery.
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Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation.
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Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.
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Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.
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Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
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Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.
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Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.
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Epigenetic regulation of AXL and risk of childhood asthma symptoms.
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Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
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Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures.
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Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B.
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Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib.
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Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.
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Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
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Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
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Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA.
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Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines.
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Expression level is a key determinant of E2F1-mediated cell fate.
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Expression of c-fos in parietal endoderm, amnion and differentiating F9 teratocarcinoma cells.
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Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina.
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Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.
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Expression of protooncogene c-myb in normal human hematopoietic cells.
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Expression of the c-erbB-2 (HER-2/neu) oncoprotein in human prostatic carcinoma.
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FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia.
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Familial polycythemia due to truncations of the erythropoietin receptor.
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Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
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Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
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Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
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Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.
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Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay.
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Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
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Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.
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Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.
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Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch.
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Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.
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G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications.
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GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription.
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GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.
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Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines.
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Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
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Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.
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Genes on the wing.
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Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
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Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck.
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Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck.
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Genetics of cerebral cavernous malformations.
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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
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Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient.
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Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
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Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
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Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.
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HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.
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HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.
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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
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HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression.
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HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
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Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.
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Heritable resistance to tyrosine kinase inhibitors.
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High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
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Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.
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Histological and molecular evaluation of patient-derived colorectal cancer explants.
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Homeostatic control of lymphocyte survival: potential origins and implications.
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How the zebrafish gets its stripes.
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Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
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Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility.
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Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.
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Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.
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Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells.
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IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
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ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.
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Identification of STRA6 and SKI sequence variants in patients with anophthalmia/microphthalmia.
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Identification of a melanoma susceptibility locus and somatic mutation in TET2.
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Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
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Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.
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Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.
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Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
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Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
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Importance of a c-Myb binding site for lymphomagenesis by the retrovirus SL3-3.
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In Reply to 'Neutrophil Gelatinase-Associated Lipocalin (NGAL), Neutrophils, and CKD: Which Comes First?'.
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
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Increased erbB-2 gene copies and expression in multiple stages of breast cancer.
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Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects.
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Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
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Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.
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Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.
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Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
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Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
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Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
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Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells.
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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
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Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.
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Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
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Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.
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Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
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Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
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Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth.
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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
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Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
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Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.
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Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha.
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JAK2 is required for induction of the murine DUB-1 gene.
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KRAS mutation influences recurrence patterns in patients undergoing hepatic resection of colorectal metastases.
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KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
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KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
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Kidney α-intercalated cells and lipocalin 2: defending the urinary tract.
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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
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Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
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LigAmp for sensitive detection of single-nucleotide differences.
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Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17.
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Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.
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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.
-
Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast.
-
Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation.
-
Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.
-
Loss of KAI1 expression in the progression of colorectal cancer.
-
Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.
-
Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.
-
Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.
-
Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB.
-
MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
-
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.
-
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
-
MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.
-
MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma.
-
Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.
-
Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells.
-
Mass spectrometry as a readout of protein structure and function.
-
Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
-
Mechanical homeostasis is altered in uterine leiomyoma.
-
Mechanical unfolding of an ankyrin repeat protein.
-
Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.
-
MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury.
-
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
-
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
-
Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity.
-
Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.
-
Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.
-
Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
-
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
-
Molecular alternations in uveal melanoma.
-
Molecular and cellular mechanism of angiotensin II-mediated apoptosis.
-
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia.
-
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
-
Mouse double minute 4 variants modify susceptibility to risk of recurrence in patients with squamous cell carcinoma of the oropharynx.
-
Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.
-
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination.
-
Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.
-
Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.
-
Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.
-
Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease.
-
Mutational analysis of the TrkA gene in prostate cancer.
-
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
-
Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.
-
Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila.
-
Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).
-
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
-
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.
-
NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.
-
NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
-
Negative regulation of Armadillo, a Wingless effector in Drosophila.
-
Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism.
-
Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart.
-
Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium.
-
Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study.
-
Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression.
-
No association between the WNT2 gene and autistic disorder.
-
Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction.
-
Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.
-
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
-
Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine.
-
Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells.
-
Novel human bronchial epithelial cell lines for cystic fibrosis research.
-
Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.
-
Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells.
-
Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells.
-
Nuclear tyrosine kinases: from Abl to WEE1.
-
Over-expression of cyclin D1 regulates Cdk4 protein synthesis.
-
Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease.
-
Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.
-
Overexpression of basic fibroblast growth factor (FGF-2) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells.
-
Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma.
-
Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression.
-
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
-
P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells.
-
PI3K/Akt and apoptosis: size matters.
-
Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histologic and immunohistochemical features.
-
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.
-
Parc-ing p53 in the cytoplasm.
-
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
-
Pathways of apoptosis in lymphocyte development, homeostasis, and disease.
-
Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
-
Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery.
-
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
-
Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer.
-
Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes.
-
Phenotypic consequences of lung-specific inducible expression of FGF-3.
-
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
-
Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures.
-
Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.
-
Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.
-
Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.
-
Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery.
-
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
-
Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway.
-
Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.
-
Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium.
-
Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
-
Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases.
-
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
-
Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.
-
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
-
Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer.
-
Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
-
Protein phosphatase 2A: a panoply of enzymes.
-
Proteomic identification of the cerebral cavernous malformation signaling complex.
-
Public funding of understanding nature.
-
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
-
Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures.
-
RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.
-
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development.
-
Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
-
Rare codons regulate KRas oncogenesis.
-
Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems.
-
Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo.
-
Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.
-
Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.
-
Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.
-
Regulation of T cell receptor delta gene rearrangement by c-Myb.
-
Regulation of apoptosis in S49 cells.
-
Regulation of apoptosis in Xenopus egg extracts.
-
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
-
Regulation of casein kinase I epsilon activity by Wnt signaling.
-
Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
-
Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium.
-
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
-
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
-
Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.
-
Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb.
-
RelB cellular regulation and transcriptional activity are regulated by p100.
-
Relationship between statin use and colon cancer recurrence and survival: results from CALGB 89803.
-
Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression.
-
Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia.
-
Requirements for cell cycle arrest by p16INK4a.
-
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.
-
Role of the ABL oncogene tyrosine kinase activity in human leukaemia.
-
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
-
Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
-
Segregation at three loci explains familial and population risk in Hirschsprung disease.
-
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
-
Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.
-
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.
-
Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection.
-
Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma.
-
Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
-
Serum levels of HER-2 neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer.
-
Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
-
Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface.
-
Signaling by wingless in Drosophila.
-
Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.
-
Sprinter: a novel transmembrane protein required for Wg secretion and signaling.
-
Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.
-
Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
-
Suppressor of fused negatively regulates beta-catenin signaling.
-
Survival of acute myeloid leukemia cells requires PI3 kinase activation.
-
Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555).
-
Synergy between tumor immunotherapy and antiangiogenic therapy.
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
-
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
-
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.
-
TET2 Deficiency Sets the Stage for B-cell Lymphoma.
-
TET2 binds the androgen receptor and loss is associated with prostate cancer.
-
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.
-
Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity.
-
Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.
-
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.
-
The CD28 signaling pathway regulates glucose metabolism.
-
The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast.
-
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
-
The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
-
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
-
The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity.
-
The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.
-
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
-
The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.
-
The beta-interferon-mediated antimitogenic state resembles the anti-viral state.
-
The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.
-
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
-
The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis.
-
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.
-
The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.
-
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
-
The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis.
-
The dishevelled protein is modified by wingless signaling in Drosophila.
-
The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells.
-
The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines.
-
The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.
-
The expression of platelet-derived growth-factor gene in Dupuytren contracture.
-
The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site.
-
The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo.
-
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
-
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.
-
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
-
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.
-
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.
-
Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.
-
Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation.
-
Transcription of the RelB gene is regulated by NF-kappaB.
-
Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.
-
Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
-
Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3.
-
Treatment of KRAS-Mutant Non-Small Cell Lung Cancer: The End of the Beginning for Targeted Therapies.
-
Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients.
-
Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.
-
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
-
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
-
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.
-
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
-
Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology.
-
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
-
Urinary NGAL marks cystic disease in HIV-associated nephropathy.
-
Urine NGAL as a biomarker of kidney damage after on- and off-pump coronary artery bypass graft surgery: a prospective pilot study.
-
Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide.
-
Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.
-
Vascular morphogenesis: tales of two syndromes.
-
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
-
Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.
-
Wingless signaling generates pattern through two distinct mechanisms.
-
Wingless signaling: an axin to grind.
-
Wnt signaling: an embarrassment of receptors.
-
Wnt signalling shows its versatility.
-
Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma.
-
[Bcl-2 and bax expression in rat cerebral ischemic preconditioning].
-
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
-
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
-
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
-
c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer.
-
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
-
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
-
miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
-
mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.
-
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.
-
p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas.
-
p53 and mdm-2 expression in malignant melanoma: an immunocytochemical study of expression of p53, mdm-2, and markers of cell proliferation in primary versus metastatic tumors.
-
p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB.
-
pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
-
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
-
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
-
Keywords of People
-
Bejsovec, Amy,
Associate Professor of Biology,
Biology
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
-
Lee, Walter T,
Professor of Head and Neck Surgery and Communication Sciences,
Radiation Oncology
-
McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
-
Patel, Uptal Dinesh,
Adjunct Professor in the Department of Medicine,
Medicine, Nephrology
-
Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
-
Swaminathan, Madhav,
Professor of Anesthesiology,
Anesthesiology, Cardiothoracic
-
Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine,
Immunology
-
Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology