Protons

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  Subject Areas on Research

  • (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein. 
  • 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. 
  • 1H NMR spectroscopy of DNA. 
  • 3-D comparative study of proton vs. x-ray radiation therapy for rectal cancer. 
  • 3Din vivodose verification in prostate proton therapy with deep learning-based proton-acoustic imaging. 
  • A feasibility study of enhanced prompt gamma imaging for range verification in proton therapy using deep learning. 
  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study. 
  • A nuclear magnetic resonance study of the interaction of L-epinephrine with phospholipid vesicles. 
  • A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion. 
  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • Accuracy of inhomogeneity correction in photon radiotherapy from CT scans with different settings. 
  • Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. 
  • Acid potentiation of the capsaicin receptor determined by a key extracellular site. 
  • Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria. 
  • Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. 
  • Allostery in Callinectes sapidus hemocyanin: cooperative oxygen binding and interactions with L-lactate, calcium, and protons. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Altered development of the dorsolateral prefrontal cortex in chromosome 22q11.2 deletion syndrome: an in vivo proton spectroscopy study. 
  • Antimatter in the proton is more down than up. 
  • Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis. 
  • Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. 
  • Automated whole-brain N-acetylaspartate proton MRS quantification. 
  • Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. 
  • Biochemistry and theory of proton-coupled electron transfer. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Calibration of methylene-referenced lipid-dissolved xenon frequency for absolute MR temperature measurements. 
  • Catalytic mechanism of 4-oxalocrotonate tautomerase: significances of protein-protein interactions on proton transfer pathways. 
  • Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Chloride and pH dependence of cooperative interactions in Limulus polyphemus hemocyanin. 
  • Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study. 
  • Computational design of a biologically active enzyme. 
  • Computational study on the relative acidity of acetic acid by the qm/mm method combined with the theory of energy representation 
  • Concerted O atom-proton transfer in the O-O bond forming step in water oxidation. 
  • Concerted proton transfer mechanism of Clostridium thermocellum ribose-5-phosphate isomerase. 
  • Conformational changes in the photocycle of Anabaena sensory rhodopsin: absence of the Schiff base counterion protonation signal. 
  • Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions. 
  • Considerations in fractionated proton radiation therapy: clinical potential and results. 
  • Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations. 
  • Correlated particle transport enables biological free energy transduction. 
  • Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy. 
  • Dependence of residual dipolar couplings on foot angle in (1)H MR spectra from skeletal muscle. 
  • Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. 
  • Editorial overview: Biological pathways for electrons, protons and photo-excitations. 
  • Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. 
  • Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins. 
  • Feasibility of using PRESAGE® for relative 3D dosimetry of small proton fields. 
  • Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study. 
  • Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. 
  • Functional equivalence of monomeric (shark) and dimeric (bovine) cytochrome c oxidase. 
  • Functional reconstitution of purified human Hv1 H+ channels. 
  • Global brain metabolic quantification with whole-head proton MRS at 3 T. 
  • Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein. 
  • Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease. 
  • Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme. 
  • In vivo measurement of proton diffusion in the presence of coherent motion. 
  • Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer. 
  • Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage. 
  • Ion fluxes and differentiation in transformed cell lines. 
  • Isomer-Selective Detection of Hydrogen-Bond Vibrations in the Protonated Water Hexamer 
  • Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study. 
  • Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis. 
  • MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging. 
  • MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials. 
  • Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization. 
  • Measurements of the top-quark mass and the tt cross section in the hadronic τ+jets decay channel at sqrt[s] = 1.96 TeV. 
  • Mechanism of Side Chain-Controlled Proton Conductivity in Bioinspired Peptidic Nanostructures. 
  • Mechanistic aspects of carbon monoxide formation from volatile anesthetics. 
  • Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. 
  • Method for studying kinetics of light-induced transport across membranes. 
  • Methodological consensus on clinical proton MRS of the brain: Review and recommendations. 
  • Methodology for the measurement and analysis of relaxation times in proton imaging. 
  • Multiaxial fields improve SABRE efficiency by preserving hydride order. 
  • Multicenter Validation of Association Between Decline in MRI-PDFF and Histologic Response in NASH. 
  • Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. 
  • New insights into the proton-dependent oxygen affinity of Root effect haemoglobins. 
  • New techniques for imaging and analyzing lung tissue. 
  • Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. 
  • Peak alignment of urine NMR spectra using fuzzy warping. 
  • Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. 
  • Prospective comparison of longitudinal change in hepatic proton density fat fraction (PDFF) estimated by magnitude-based MRI (MRI-M) and complex-based MRI (MRI-C). 
  • Protective role of transient pore openings in calcium handling by cardiac mitochondria. 
  • Proton NMR of Escherichia coli sulfite reductase: studies of the heme protein subunit with added ligands. 
  • Proton Therapy for Brain Metastases: A Question of Value. 
  • Proton Whole-Lung Irradiation: Initial Report of Outcomes. 
  • Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats. 
  • Proton density water fraction as a reproducible MR-based measurement of breast density. 
  • Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination. 
  • Proton nuclear magnetic resonance assignments and structural characterization of an intramolecular DNA triplex. 
  • Proton-beam irradiated epithelioid cell melanoma of the ciliary body. 
  • Proton-beam therapy after radical prostatectomy: Continued DVH idolatry? 
  • Proton-coupled electron transfer. 
  • Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys. 
  • Proton-gated ion channels in mouse bone marrow stromal cells. 
  • Protonation of the neutral repeats of the RNA polymerase II CTD. 
  • Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin. 
  • Pulsed EPR studies of nonexchangeable protons near the Mo(V) center of sulfite oxidase: direct detection of the alpha-proton of the coordinated cysteinyl residue and structural implications for the active site. 
  • Pulsed EPR studies of the exchangeable proton at the molybdenum center of dimethyl sulfoxide reductase. 
  • Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy. 
  • Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. 
  • Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. 
  • Radiation therapy of sarcomas of the soft tissues. 
  • Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Representation of strong baseline contributions in 1H MR spectra. 
  • Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain. 
  • SABRE enhancement with oscillating pulse sequences. 
  • Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector. 
  • Search for the standard model Higgs Boson produced in association with top quarks using the full CDF data set. 
  • Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap. 
  • Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus. 
  • Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI. 
  • Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position. 
  • Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex. 
  • Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis. 
  • Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. 
  • Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics. 
  • Targeting Hv1 proton channel for pain control. 
  • Temperature-corrected proton density fat fraction estimation using chemical shift-encoded MRI in phantoms. 
  • The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. 
  • The effect of a probiotic on hepatic steatosis. 
  • The renal excretion of hydrogen ion in renal tubular acidosis. I. quantitative assessment of the response to ammonium chloride as an acid load. 
  • The renal excretion of hydrogen ion in renal tubular acidosis. II. Quantitative response to the carbonic anhydrase inhibitor, acetazolamide. 
  • Theoretical and experimental determination on two substrates turned over by 4-oxalocrotonate tautomerase. 
  • Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. 
  • Thermopower of molecular junctions: an ab initio study. 
  • Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat. 
  • Transmission coefficient calculation for proton transfer in triosephosphate isomerase based on the reaction path potential method. 
  • Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane. 
  • Use of gel filtration in the preparation of biological fluids for magnetic resonance spectroscopy. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering