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Subject Areas on Research
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A molybdopterin-free form of xanthine oxidase.
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A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli.
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Absence of hepatic molybdenum cofactor: an inborn error of metabolism leading to a combined deficiency of sulphite oxidase and xanthine dehydrogenase.
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Activation of phenylalanine hydroxylase by phenylalanine.
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An HPLC assay for detection of elevated urinary S-sulphocysteine, a metabolic marker of sulphite oxidase deficiency.
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An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides.
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Assay and detection of the molybdenum cofactor.
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Biosynthesis and processing of the molybdenum cofactors.
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C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.
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Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor.
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Characterization of molybdenum cofactor from Escherichia coli.
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Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component.
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Chemistry and biology of the molybdenum cofactor.
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Chemistry and biology of the molybdenum cofactors.
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Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination.
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Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli.
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Defective molybdopterin biosynthesis: clinical heterogeneity associated with molybdenum cofactor deficiency.
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Escherichia coli MoeA and MogA. Function in metal incorporation step of molybdenum cofactor biosynthesis.
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Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules.
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Human molybdenum cofactor deficiency.
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Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
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Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.
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Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa.
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Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea.
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In vitro incorporation of nascent molybdenum cofactor into human sulfite oxidase.
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In vitro reconstitution of nitrate reductase activity of the Neurospora crassa mutant nit-1: specific incorporation of molybdopterin.
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In vitro synthesis of molybdopterin from precursor Z using purified converting factor. Role of protein-bound sulfur in formation of the dithiolene.
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In vitro system for molybdopterin biosynthesis.
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Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor.
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Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.
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Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies.
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Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis.
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Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis.
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Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis.
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Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue.
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Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
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Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.
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Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli.
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Molybdenum cofactor biosynthesis in Escherichia coli mod and mog mutants.
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Molybdenum cofactor biosynthesis in Escherichia coli. Requirement of the chlB gene product for the formation of molybdopterin guanine dinucleotide.
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Molybdenum cofactor deficiency associated with Dandy-Walker malformation.
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Molybdopterin biosynthesis in man. Properties of the converting factor in liver tissue from a molybdenum cofactor deficient patient.
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Molybdopterin from molybdenum and tungsten enzymes.
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Molybdopterin guanine dinucleotide: a modified form of molybdopterin identified in the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides forma specialis denitrificans.
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Molybdopterin in carbon monoxide oxidase from carboxydotrophic bacteria.
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Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency.
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Molybdopterin--problems and perspectives.
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Novel aspects of the biochemistry of the molybdenum cofactor.
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Oxidation of molybdopterin in sulfite oxidase by ferricyanide. Effect on electron transfer activities.
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Phenylalanine hydroxylase in dilute lethal mice.
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Prenatal diagnosis of molybdenum cofactor deficiency by assay of sulphite oxidase activity in chorionic villus samples.
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Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimurium.
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Radical Breakthroughs in Natural Product and Cofactor Biosynthesis.
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Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity.
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Resonance Raman spectroscopic characterization of the molybdopterin active site of DMSO reductase.
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Specific incorporation of molybdopterin in xanthine dehydrogenase of Pseudomonas aeruginosa.
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Structural and metabolic relationship between the molybdenum cofactor and urothione.
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Structural characterization of a molybdopterin precursor.
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The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor.
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The mechanisms of inactivation of sulfite oxidase by periodate and arsenite.
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The pterin component of the molybdenum cofactor. Structural characterization of two fluorescent derivatives.
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The pterin molybdenum cofactors.
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The relationship of Mo, molybdopterin, and the cyanolyzable sulfur in the Mo cofactor.
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The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria.
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The state of reduction of molybdopterin in xanthine oxidase and sulfite oxidase.
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The structure of a molybdopterin precursor. Characterization of a stable, oxidized derivative.
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The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase.
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Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase.
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Two proteins encoded at the chlA locus constitute the converting factor of Escherichia coli chlA1.
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Urinary excretion of biopterin and neopterin in psychiatric disorders.