Pulmonary Alveoli

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  Subject Areas on Research

  • A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. 
  • A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A platelet-derived growth factor homolog secreted by alveolar macrophages is complexed to an alpha-macroglobulin. 
  • A small animal model of regional alveolar ventilation using HP 3He MRI1. 
  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Acute toxicity of lead particulates on pulmonary alveolar macrophages. Ultrastructural and microanalytical studies. 
  • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. 
  • Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis. 
  • Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis. 
  • Ager-CreERT2: A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair. 
  • Airway branching patterns influence asbestos fiber location and the extent of tissue injury in the pulmonary parenchyma. 
  • Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. 
  • Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. 
  • Alpha-macroglobulin secreted by alveolar macrophages serves as a binding protein for a macrophage-derived homologue of platelet-derived growth factor. 
  • Alterations of surfactant pools in fetal and newborn rat lungs. 
  • Altered surfactant function and structure in SP-A gene targeted mice. 
  • Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung. 
  • Alveolar epithelial cell injuries by subchronic exposure to low concentrations of ozone correlate with cumulative exposure. 
  • Alveolar septal structure in different species. 
  • Alveolar type II cell responses to chronic inhalation of chrysotile asbestos in rats. 
  • An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. 
  • Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. 
  • Asbestos bodies in bronchoalveolar lavage fluid. A study of 20 asbestos-exposed individuals and comparison to patients with other chronic interstitial lung diseases. 
  • Asbestos body phagocytosis by human free alveolar macrophages. 
  • Bacterial penetration of the mucosal barrier by targeting lipid rafts. 
  • Bacterial priming increases lung injury in gram-negative sepsis. 
  • Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware Trial. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. 
  • Brief 95% O2 exposure effects on surfactant protein and mRNA in rat alveolar and bronchiolar epithelium. 
  • Brief exposure to 95% oxygen alters surfactant protein D and mRNA in adult rat alveolar and bronchiolar epithelium. 
  • CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis. 
  • Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane. 
  • Catastrophic antiphospholipid syndrome with concurrent thrombotic and hemorrhagic manifestations. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Cellular and connective tissue changes in alveolar septal walls in emphysema. 
  • Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis. 
  • Characteristics of macrophages obtained by bronchial lavage in humans. 
  • Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. 
  • Chronic obstructive pulmonary disease: emerging medical therapies. 
  • Chrysotile asbestos and H2O2 increase permeability of alveolar epithelium. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease. 
  • Comment on Expression of Concern: c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice. 
  • Comparison of phagocytosis of uncoated versus coated asbestos fibers by cultured human pulmonary alveolar macrophages. 
  • Composition of lung lavage in pulmonary alveolar microlithiasis. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. 
  • Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Current issues in mechanical ventilation for respiratory failure. 
  • Delayed Alveolar Epithelialization: A Distinct Pathology in Diffuse Acute Lung Injury. 
  • Determining deposition sites of inhaled lung particles and their effect on clearance. 
  • Development of alterations in hamster distal lung following exposure to fly ash from fluidized bed coal combustion: a morphometric study. 
  • Differences between particulate and peptide stimuli on activation of oxidant production in alveolar macrophages. 
  • Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung. 
  • Diffuse alveolar damage after exposure to an oil fly ash. 
  • Diffusing capacity of the lung for carbon monoxide. 
  • Early changes of lung function and structure in an elastase model of emphysema—a hyperpolarized 3He MRI study 
  • Effect of high oxygen tension on mucociliary function. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Effects of Alveolar Recruitment and Positive End-Expiratory Pressure on Oxygenation during One-Lung Ventilation in the Supine Position. 
  • Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA. 
  • Effects of inhalation of 0.12 and 0.25 parts per million ozone on the proximal alveolar region of juvenile and adult rats. 
  • Effects of low levels of NO2 on terminal bronchiolar cells and its relative toxicity compared to O3. 
  • Effects of subchronic inhalation of low concentrations of nitrogen dioxide. I. The proximal alveolar region of juvenile and adult rats. 
  • Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome. 
  • Elevated serum immunoglobulin G levels and bronchoalveolar lymphocytosis as predictors of clinical course in pulmonary sarcoidosis. 
  • Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. 
  • Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. 
  • Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo. 
  • Exposure to hyperoxia induces p53 expression in mouse lung epithelium. 
  • Exposure to low levels of ozone results in enhanced pulmonary retention of inhaled asbestos fibers. 
  • Expression of the cystic fibrosis gene in adult human lung. 
  • Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Fibrosing alveolitis in patients with neurofibromatosis. 
  • Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. 
  • Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. 
  • Ga-67 uptake in the lung in sarcoidosis. 
  • Gas mixing in a model of the pulmonary acinus with asymmetrical alveolar ducts. 
  • Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation. 
  • Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat. 
  • Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • High versus low PEEP in ARDS. 
  • Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids. 
  • Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate. 
  • Human lung innate immune response to Bacillus anthracis spore infection. 
  • Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells. 
  • Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. 
  • Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. 
  • Hyperoxia inhibits nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1. 
  • Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. 
  • IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. 
  • IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. 
  • IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. 
  • Identification of early interactions between Francisella and the host. 
  • Immunopathologic studies of an experimental model resembling Goodpasture's syndrome. 
  • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. 
  • Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. 
  • Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. 
  • Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. 
  • Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. 
  • Inhomogeneity of ventilatory unit volume and its effects on reactive gas uptake. 
  • Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD. 
  • Interstitial thickening in pulmonary alveolar microlithiasis: an underappreciated finding. 
  • Intravascular coagulation--a source of possible error in carbon-clearance determinations. 
  • Ionic content and regulation of cellular volume in rat alveolar type II cells. 
  • Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury? 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. 
  • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 
  • Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring. 
  • Measurements of Regional Alveolar Oxygen Pressure Using Hyperpolarized 3He MRI1 
  • Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. 
  • Minimum alveolar concentration for halothane in the rat is resistant to effects of forebrain ischemia and reperfusion. 
  • Molecular and functional properties of lung SP cells. 
  • Molecular mechanisms of TRPV4-mediated neural signaling. 
  • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. 
  • Morphologic aspects of the protection by endotoxin against acute and chronic oxygen-induced lung injury in adult rats. 
  • Morphometric characteristics of cells in the alveolar region of mammalian lungs. 
  • Multilamellar bodies in alveolar septal cells. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses. 
  • Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats. 
  • Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration. 
  • New techniques for imaging and analyzing lung tissue. 
  • Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. 
  • Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. 
  • Oxygen toxicity. 
  • PEEP in the morning, PEEP at night. 
  • Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values. 
  • Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum. 
  • Plasma proteins of the bronchoalveolar surface of the lungs of smokers and nonsmokers. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Pleural amyloidosis. 
  • Postnatal growth and size of the pulmonary acinus and secondary lobule in man. 
  • Postnatal growth of pulmonary acini and alveoli in normal and oxygen-exposed rats studied by serial section reconstructions. 
  • Powdered tantalum. 
  • Preparative techniques for freezing and freeze-sectioning macrophages for energy dispersive x-ray microanalysis. 
  • Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. 
  • Progressive alveolar septal injury in primates exposed to 60% oxygen for 14 days. 
  • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. 
  • Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. 
  • Pulmonary cytology of the acquired immune deficiency syndrome: an analysis of 36 cases. 
  • Pulmonary fibrosis: patterns and perpetrators. 
  • Pulmonary gas exchange in humans exercising at sea level and simulated altitude. 
  • Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe. 
  • Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. 
  • Pulmonary toxicity associated with fly ash from fluidized bed coal combustion. II. Cellular morphometry of distal lung following a single intratracheal instillation. 
  • Rat lung surfactant kinetics biochemical and morphometric correlation. 
  • Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial. 
  • Receptors for immunoglobulin and complement on human alveolar macrophages. 
  • Regional pulmonary function during experimental unilateral pneumothorax in the awake state. 
  • Relationship of ventilation and inspired oxygen concentration to mucociliary clearance. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Resolution of lung inflammation by CD44. 
  • Role of complement activation in a model of adult respiratory distress syndrome. 
  • Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. 
  • Secretion of surfactant by rat alveolar type II cells: morphometric analysis and three-dimensional reconstruction. 
  • Setting the frequency-tidal volume pattern. 
  • Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells. 
  • Stemming Lung Disease? 
  • Studies on the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man. 
  • Superoxide production by digitonin-stimulated guinea pig granulocytes. The effects of N-ethyl maleimide, divalent cations; and glycolytic and mitochondrial inhibitors on the activation of the superoxide generating system. 
  • Supramicron-sized particle clearance from alveoli: route and kinetics. 
  • TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. 
  • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. 
  • The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. 
  • The acute respiratory distress syndrome. 
  • The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The effect of ventilation and oxygen on mucociliary clearance and alveolar stability. 
  • The pulmonary surfactant system. 
  • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 
  • Three-dimensional reconstruction and quantitative analysis of rat lung type II cells: a computer-based study. 
  • Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Type II cell response to chronic beta adrenergic agonist and antagonist infusions. 
  • Ultrastructural morphology of the lung in cystic fibrosis. 
  • Ultrastructure and x-ray microanalysis of macrophages exposed to cadmium chloride. 
  • c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. 
  • β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Moon, Richard Edward, Professor of Anesthesiology, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology