Pulmonary Surfactants

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  Subject Areas on Research

  • A comparison of the outcomes of neonates treated with two different natural surfactants. 
  • A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. 
  • A multicenter randomized masked comparison trial of synthetic surfactant versus calf lung surfactant extract in the prevention of neonatal respiratory distress syndrome. 
  • A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. 
  • A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure. 
  • Accuracy of the 7-8-9 Rule for endotracheal tube placement in the neonate. 
  • Adjunctive treatments in pediatric acute respiratory distress syndrome. 
  • Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf). 
  • Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry. 
  • Aerosolized medications for altering lung surface active properties. 
  • Alterations of surfactant pools in fetal and newborn rat lungs. 
  • Altered surfactant function and structure in SP-A gene targeted mice. 
  • Alveolar proteinosis: a disease of mice and men. 
  • An extracorporeal artificial placenta supports extremely premature lambs for 1 week. 
  • Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Brief 95% O2 exposure effects on surfactant protein and mRNA in rat alveolar and bronchiolar epithelium. 
  • Brief exposure to 95% oxygen alters surfactant protein D and mRNA in adult rat alveolar and bronchiolar epithelium. 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. 
  • Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. 
  • Comparative effectiveness of surfactant preparations in premature infants. 
  • Composition of lung lavage in pulmonary alveolar microlithiasis. 
  • Dexamethasone increases adult rat lung surfactant lipids. 
  • Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model. 
  • Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung. 
  • Early CPAP versus surfactant in extremely preterm infants. 
  • Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants. 
  • Effect of benzyl alcohol on lipid bilayers. A comparisons of bilayer systems. 
  • Effect of high oxygen tension on mucociliary function. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Exposure to hyperoxia induces p53 expression in mouse lung epithelium. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. 
  • Functional assessment of a multicenter very low-birth-weight cohort at age 5 years. Newborn Lung Project. 
  • Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage. 
  • Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. 
  • Hydration force and bilayer deformation: a reevaluation. 
  • Incorporation of biotinylated SP-A into rat lung surfactant layer, type II cells, and clara cells. 
  • Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. 
  • Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally. 
  • Management of acute lung injury: sharing data between adults and children. 
  • Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation. 
  • Mechanical ventilation of rat lung: effect on surfactant forms. 
  • Molecular and cellular processing of lung surfactant. 
  • Mortality and pulmonary outcomes of extremely preterm infants exposed to antenatal corticosteroids. 
  • Multilamellar bodies in alveolar septal cells. 
  • Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses. 
  • Neonatal and pediatric respiratory care: what does the future hold? 
  • Neurodevelopmental and health outcomes in term infants treated with surfactant for severe respiratory failure. 
  • Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial. 
  • One-year outcome in 232 premature infants with birth weights of 750 to 1249 grams and respiratory distress syndrome randomized to rescue treatment with two doses of synthetic surfactant or air placebo. Canadian Exosurf Neonatal Study Group. 
  • Outcome at 1-year adjusted age of 957 infants weighing more than 1250 grams with respiratory distress syndrome randomized to receive synthetic surfactant or air placebo. American and Canadian Exosurf Neonatal Study Groups. 
  • Oxygen toxicity. 
  • PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT). 
  • Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. 
  • Pediatric acute respiratory distress syndrome. 
  • Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. 
  • Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. 
  • Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. 
  • Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network. 
  • Prevention of bronchopulmonary dysplasia. 
  • Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. 
  • Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 
  • Pulmonary surfactant lipid production in oxygen-exposed rat lungs. 
  • Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. 
  • Pulmonary toxicity of trichloroethylene: induction of changes in surfactant phospholipids and phospholipase A2 activity in the mouse lung. 
  • Rat lung surfactant kinetics biochemical and morphometric correlation. 
  • Recycling of surfactant lipid and apoprotein-A studied by electron microscopic autoradiography. 
  • Regulation of gene expression in the lung. 
  • Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). 
  • Respiratory symptoms at age 8 years in a cohort of very low birth weight children. 
  • Role of lymphatics in removal of sheep lung surfactant lipid. 
  • Role of surfactant and hyperoxia. 
  • Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. 
  • Secretion of surfactant by rat alveolar type II cells: morphometric analysis and three-dimensional reconstruction. 
  • Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells. 
  • Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. 
  • Strategies for analysis of gene expression: pulmonary surfactant proteins. 
  • Surfactant Administration in Preterm Infants: Drug Development Opportunities. 
  • Surfactant apoprotein A (SP-A) is synthesized in airway cells. 
  • Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone. 
  • Surfactant protein A enhances apoptotic cell uptake and TGF-beta1 release by inflammatory alveolar macrophages. 
  • Surfactant protein A regulates complement activation. 
  • Surfactant treatment of full-term newborns with respiratory failure. 
  • Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury. 
  • Target ranges of oxygen saturation in extremely preterm infants. 
  • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 
  • The OHRP and SUPPORT. 
  • The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens. 
  • The organization of n-alkanes in lipid bilayers. 
  • The pulmonary surfactant system. 
  • The stability of silver nanoparticles in a model of pulmonary surfactant. 
  • The stimulation of cellular phospholipid uptake by surfactant apoproteins. 
  • Three-dimensional reconstruction of tubular myelin. 
  • Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro. 
  • Type II cell response to chronic beta adrenergic agonist and antagonist infusions. 
  • Use of the TDx-FLM assay in evaluating fetal lung maturity in an insulin-dependent diabetic population. The Diabetes and Fetal Maturity Study Group. 
  • Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture. 
  • [Management of the acute respiratory distress syndrome]. 
  • [Other indications for surfactant]. 
  • [The impact of mechanical ventilation strategies that minimize atelectrauma in an experimental model of acute lung injury]. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology