Pulmonary Surfactants

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  Subject Areas on Research

  • A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure. 
  • Accuracy of the 7-8-9 Rule for endotracheal tube placement in the neonate. 
  • Adjunctive treatments in pediatric acute respiratory distress syndrome. 
  • Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf). 
  • Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry. 
  • Aerosolized medications for altering lung surface active properties. 
  • Alterations of surfactant pools in fetal and newborn rat lungs. 
  • Altered surfactant function and structure in SP-A gene targeted mice. 
  • Alveolar proteinosis: a disease of mice and men. 
  • An extracorporeal artificial placenta supports extremely premature lambs for 1 week. 
  • Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. 
  • Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. 
  • Comparative effectiveness of surfactant preparations in premature infants. 
  • Composition of lung lavage in pulmonary alveolar microlithiasis. 
  • Dexamethasone increases adult rat lung surfactant lipids. 
  • Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model. 
  • Early CPAP versus surfactant in extremely preterm infants. 
  • Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants. 
  • Effect of benzyl alcohol on lipid bilayers. A comparisons of bilayer systems. 
  • Effect of high oxygen tension on mucociliary function. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Exposure to hyperoxia induces p53 expression in mouse lung epithelium. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Functional assessment of a multicenter very low-birth-weight cohort at age 5 years. Newborn Lung Project. 
  • Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage. 
  • Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. 
  • Hydration force and bilayer deformation: a reevaluation. 
  • Incorporation of biotinylated SP-A into rat lung surfactant layer, type II cells, and clara cells. 
  • Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. 
  • Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally. 
  • Management of acute lung injury: sharing data between adults and children. 
  • Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation. 
  • Mechanical ventilation of rat lung: effect on surfactant forms. 
  • Molecular and cellular processing of lung surfactant. 
  • Multilamellar bodies in alveolar septal cells. 
  • Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses. 
  • Neonatal and pediatric respiratory care: what does the future hold? 
  • Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial. 
  • Oxygen toxicity. 
  • PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT). 
  • Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. 
  • Pediatric acute respiratory distress syndrome. 
  • Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. 
  • Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. 
  • Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network. 
  • Prevention of bronchopulmonary dysplasia. 
  • Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. 
  • Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 
  • Pulmonary surfactant lipid production in oxygen-exposed rat lungs. 
  • Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. 
  • Rat lung surfactant kinetics biochemical and morphometric correlation. 
  • Regulation of gene expression in the lung. 
  • Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). 
  • Respiratory symptoms at age 8 years in a cohort of very low birth weight children. 
  • Role of lymphatics in removal of sheep lung surfactant lipid. 
  • Role of surfactant and hyperoxia. 
  • Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. 
  • Secretion of surfactant by rat alveolar type II cells: morphometric analysis and three-dimensional reconstruction. 
  • Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells. 
  • Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. 
  • Strategies for analysis of gene expression: pulmonary surfactant proteins. 
  • Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone. 
  • Surfactant protein A regulates complement activation. 
  • Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury. 
  • Target ranges of oxygen saturation in extremely preterm infants. 
  • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 
  • The OHRP and SUPPORT. 
  • The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens. 
  • The organization of n-alkanes in lipid bilayers. 
  • The pulmonary surfactant system. 
  • The stability of silver nanoparticles in a model of pulmonary surfactant. 
  • The stimulation of cellular phospholipid uptake by surfactant apoproteins. 
  • Three-dimensional reconstruction of tubular myelin. 
  • Type II cell response to chronic beta adrenergic agonist and antagonist infusions. 
  • Use of the TDx-FLM assay in evaluating fetal lung maturity in an insulin-dependent diabetic population. The Diabetes and Fetal Maturity Study Group. 
  • Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture. 
  • [Management of the acute respiratory distress syndrome]. 
  • [Other indications for surfactant]. 
  • [The impact of mechanical ventilation strategies that minimize atelectrauma in an experimental model of acute lung injury]. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology