Purkinje Cells

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  Subject Areas on Research

  • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements. 
  • Adaptive Mesh Refinement and Adaptive Time Integration for Electrical Wave Propagation on the Purkinje System. 
  • Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. 
  • Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. 
  • Cerebellar learning using perturbations. 
  • Changes in the responses of Purkinje cells in the floccular complex of monkeys after motor learning in smooth pursuit eye movements. 
  • Dendritic development of Purkinje and granule cells in the cerebellar cortex of rats treated postnatally with alpha-difluoromethylornithine. 
  • Depression of sustained evoked potentials and glial depolarization in the spinal cord by barbiturates and by diphenylhydantoin. 
  • Detection of tracking errors by visual climbing fiber inputs to monkey cerebellar flocculus during pursuit eye movements. 
  • Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia. 
  • Encoding and decoding of learned smooth-pursuit eye movements in the floccular complex of the monkey cerebellum. 
  • FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. 
  • FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. 
  • High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. 
  • Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine. 
  • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. 
  • Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. 
  • Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning. 
  • Limited regional cerebellar dysfunction induces focal dystonia in mice. 
  • Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys. 
  • Localization of calmodulin in rat cerebellum by immunoelectron microscopy. 
  • Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. 
  • Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. 
  • Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. 
  • Modulation of Complex-Spike Duration and Probability during Cerebellar Motor Learning in Visually Guided Smooth-Pursuit Eye Movements of Monkeys. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Motor learning and memory in the vestibulo-ocular reflex: the dark side. 
  • Multiple subclasses of Purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex. 
  • Multiple subclasses of purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. I. Changes in the responses of brain stem neurons. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. II. Changes in the responses of horizontal gaze velocity Purkinje cells in the cerebellar flocculus and ventral paraflocculus. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. III. Computational and behavioral analysis of the sites of learning. 
  • Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns. 
  • Neural learning rules for the vestibulo-ocular reflex. 
  • Neural recordings and behavioral observations in the monkey vestibulo-ocular reflex constrain the cellular mechanisms for cerebellum-dependent behavioral learning. 
  • Neuronal morphology generates high-frequency firing resonance. 
  • Optimal information storage and the distribution of synaptic weights: perceptron versus Purkinje cell. 
  • Optimal properties of analog perceptrons with excitatory weights. 
  • Paraneoplastic temporal lobe epilepsy and anti-Yo autoantibody. 
  • Physiologic basis for motor learning in the vestibulo-ocular reflex. 
  • Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. 
  • Purkinje cell loss in experimental autoimmune encephalomyelitis. 
  • Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration. 
  • Response of flocculus Purkinje cells to adequate vestibular stimulation in the alert monkey: fixation vs. compensatory eye movements. 
  • Responses during eye movements of brain stem neurons that receive monosynaptic inhibition from the flocculus and ventral paraflocculus in monkeys. 
  • Responses of Purkinje cells in the oculomotor vermis of monkeys during smooth pursuit eye movements and saccades: comparison with floccular complex. 
  • Role of plasticity at different sites across the time course of cerebellar motor learning. 
  • Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex. I. Purkinje cell activity during visually guided horizontal smooth-pursuit eye movements and passive head rotation. 
  • Signals used to compute errors in monkey vestibuloocular reflex: possible role of flocculus. 
  • Simple spike responses of gaze velocity Purkinje cells in the floccular lobe of the monkey during the onset and offset of pursuit eye movements. 
  • Storage of correlated patterns in standard and bistable Purkinje cell models. 
  • Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules. 
  • TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. 
  • The Rules of Cerebellar Learning: Around the Ito Hypothesis. 
  • The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. 
  • The construction of an anatomically based model of the human ventricular conduction system. 
  • Visual motion commands for pursuit eye movements in the cerebellum. 
  • Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. I. Simple spikes. 
  • Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. II. Complex spikes. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Lisberger, Stephen, George Barth Geller Distinguished Professor for Research in Neurobiology, Neurobiology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology