Pyrethrins

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  Subject Areas on Research

  • A dual-target molecular mechanism of pyrethrum repellency against mosquitoes. 
  • A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance. 
  • A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. 
  • A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides. 
  • A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 
  • A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. 
  • Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes. 
  • Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. 
  • Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti. 
  • Characterization of deltamethrin metabolism by rat plasma and liver microsomes. 
  • Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens. 
  • Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti. 
  • Comparative field evaluation of combinations of long-lasting insecticide treated nets and indoor residual spraying, relative to either method alone, for malaria prevention in an area where the main vector is Anopheles arabiensis. 
  • DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. 
  • Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control. 
  • Developmental neurotoxicity of succeeding generations of insecticides. 
  • Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. 
  • Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. 
  • Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide. 
  • Effect of individual and community-level bed net usage on malaria prevalence among under-fives in the Democratic Republic of Congo. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of dietary exposure to the pyrethroid pesticide esfenvalerate on medaka (Oryzias latipes). 
  • Effects of permethrin-impregnated bed nets on malaria vectors of northern Guatemala. 
  • Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel. 
  • Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes. 
  • Exploring alternative insecticide delivery options in a "lethal house lure" for malaria vector control. 
  • Fine scale spatial investigation of multiple insecticide resistance and underlying target-site and metabolic mechanisms in Anopheles gambiae in central Côte d'Ivoire. 
  • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). 
  • Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. 
  • Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches (Blattella germanica). 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Molecular basis of selective resistance of the bumblebee BiNa_v 1 sodium channel to tau-fluvalinate. 
  • Molecular biology of insect sodium channels and pyrethroid resistance. 
  • Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. 
  • Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. 
  • Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti. 
  • Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. 
  • Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A. 
  • Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. 
  • Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 
  • Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. 
  • Permethrin-impregnated bed nets for malaria control in northern Guatemala: epidemiologic impact and community acceptance. 
  • Permethrin-impregnated curtains and bed-nets prevent malaria in western Kenya. 
  • Pyrethrins elicit olfactory response and spatial repellency in Aedes albopictus. 
  • Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel. 
  • Stage-specific toxicity of cypermethrin to medaka (Oryzias latipes) eggs and embryos using a refined methodology for an in vitro fertilization bioassay. 
  • Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. 
  • Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids. 
  • Transfluthrin enhances odorant receptor-mediated spatial repellency in Aedes aegypti. 
  • Use of non-mammalian alternative models for neurotoxicological study. 
  • Use of novel lab assays to examine the effect of pyrethroid-treated bed nets on blood-feeding success and longevity of highly insecticide-resistant Anopheles gambiae s.l. mosquitoes. 
  • Use of protein phosphatase inhibitors. 
  • Use of protein phosphatase inhibitors. 
  • kdr-Type resistance in insects with special reference to the German cockroach, Blattella germanica.