Pyridazines

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  Subject Areas on Research

  • A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery. 
  • A circuit model for saccadic suppression in the superior colliculus. 
  • A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. 
  • Better late than never: a welcome publication of tardy clinical trial results. 
  • Comparison of cinoxacin and nalidixic acid in patients with cystitis. 
  • Comparison of low-dose cinoxacin therapy and placebo in the prevention of recurrent urinary tract infections. 
  • DUCCS and SWANS: when U.S. site-based research was highly successful. 
  • Dead letter office. 
  • Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. 
  • Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography. 
  • Double-blind, placebo-controlled, fixed dose trial of minaprine in patients with major depression. 
  • Drug susceptibility and resistance mutations after first-line failure in resource limited settings. 
  • Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis. 
  • Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH. 
  • EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils. 
  • First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program. 
  • Inotropes in the management of acute heart failure. 
  • Janus kinase inhibitors for atopic dermatitis: a promising treatment modality. 
  • Levosimendan in Cardiac Surgery. 
  • Levosimendan in Cardiac Surgery. 
  • Levosimendan in Cardiac Surgery. 
  • Levosimendan in Cardiac Surgery. 
  • Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery. 
  • Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial. 
  • Long-lived polarization protected by symmetry. 
  • Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function. 
  • Mechanism of the luminol-dependent chemiluminescence of human neutrophils. 
  • Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study. 
  • Pyridazinones as selective cyclooxygenase-2 inhibitors. 
  • Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia. 
  • Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. 
  • Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. 
  • Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors. 
  • TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. 
  • The Evolving Landscape of Frontline Therapy in Chronic Phase Chronic Myeloid Leukemia (CML). 
  • The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude. 
  • The disconnect between phase II and phase III trials of drugs for heart failure. 
  • Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis? 
  • Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology