Diphosphates

• 

  Subject Areas on Research

  • A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa. 
  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • Binding of phosphate ligands to ribonuclease A. 
  • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. 
  • Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase. 
  • Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. 
  • Determination of the mechanism of reaction for bile acid: CoA ligase. 
  • Determination of the stoichiometry of electron uptake and the midpoint reduction potentials of milk xanthine oxidase at 25 degrees C by microcoulometry. 
  • Development of a radiolabeled ATP assay for carboxylic acid:CoA ligases and its use in the characterization of the xenobiotic carboxylic acid:CoA ligases of bovine liver mitochondria. 
  • Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. 
  • Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli. 
  • Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. 
  • Irreversible stimulation of adenylate cyclase activity of fat cell membranes of phosphoramidate and phosphonate analogs of GTP. 
  • Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. 
  • Ligand concentration regulates the pathways of coupled protein folding and binding. 
  • Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. 
  • Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells. 
  • Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. 
  • Recognition of reversible and irreversible myocardial injury by technetium pyrophosphate extraction kinetics. 
  • Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. 
  • Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG. 
  • The biological behavior of tin following administration of nine 99mTc-Sn complexes. 
  • The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis. 
  • Treatment of myasthenia gravis with octamethyl pyrophosphoramide; preliminary report. 
  • Use of octamethyl pyrophosphoramide in the treatment of myasthenia gravis; further observations.