Pyruvate Kinase

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  Subject Areas on Research

  • A bacterial selection for the directed evolution of pyruvate aldolases. 
  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Lessons from Yeast on How to Avoid Stress Eating. 
  • Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. 
  • Metabolic pathway alterations that support cell proliferation. 
  • Mitapivat versus Placebo for Pyruvate Kinase Deficiency. 
  • Morphologic, biochemical, and cytogenetic studies of bone marrow and circulating blood cells in painters exposed to ethylene glycol ethers. 
  • New roles for pyruvate kinase M2: working out the Warburg effect. 
  • Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. 
  • Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency. 
  • Pyruvate kinase deficiency in children. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Relaxation spectra of pyruvate kinase. 
  • Rewiring of glycolysis in cancer cell metabolism. 
  • TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. 
  • Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. 
  • The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency. 
  • The singly-wound parallel beta barrel: a proposed structure for 2-keto-3-deoxy-6-phosphogluconate aldolase. 
  • The structure and function of pyruvate kinase.