Quinoxalines

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  Subject Areas on Research

  • A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. 
  • A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection. 
  • A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469. 
  • AMPA receptor competitive antagonism reduces halothane MAC in rats. 
  • Adapting smoking cessation treatment according to initial response to precessation nicotine patch. 
  • An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. 
  • Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system. 
  • Anisodamine at higher concentrations in inhibiting alpha-adrenergic responses in isolated canine blood vessels. 
  • Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. 
  • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. 
  • BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. 
  • Bilateral angle closure following use of a weight loss combination agent containing topiramate. 
  • Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. 
  • Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. 
  • Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. 
  • Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility. 
  • Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. 
  • Deconstructing behavioral neuropharmacology with cellular specificity. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Dietary mutagen exposure and risk of pancreatic cancer. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. 
  • Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats. 
  • Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats. 
  • Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus. 
  • Diurnal and nocturnal effects of brimonidine monotherapy on intraocular pressure. 
  • Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. 
  • Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat. 
  • Effects of glycine receptor antagonism on spreading depression in the rat. 
  • Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study. 
  • Enantiomeric separation of an aryloxyphenoxypropanoic acid by CE and LC. 
  • Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats. 
  • Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. 
  • Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. 
  • GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. 
  • Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. 
  • Glycine antagonism does not block ischemic spontaneous depolarization in the rat. 
  • Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat. 
  • High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. 
  • IKK mediates ischemia-induced neuronal death. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. 
  • Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. 
  • Kinetic isolation of a slowly recovering component of short-term depression during exhaustive use at excitatory hippocampal synapses. 
  • Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy. 
  • Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. 
  • MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. 
  • Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths. 
  • Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus. 
  • NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. 
  • Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration. 
  • New Treatment Options for Hepatitis C Virus Infection in End-Stage Kidney Disease: To Treat or Not to Treat. 
  • New findings on nicotine addiction and treatment. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Patient engagement and study design of PROP UP: A multi-site patient-centered prospective observational study of patients undergoing hepatitis C treatment. 
  • Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor. 
  • Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. 
  • Potentiometric, electronic structural, and ground- and excited-state optical properties of conjugated bis[(porphinato)zinc(II)] compounds featuring proquinoidal spacer units. 
  • Pre-cessation varenicline treatment vs post-cessation NRT: an uneven playing field. 
  • Progression of visual field defects in leber hereditary optic neuropathy: experience of the LHON treatment trial. 
  • Propagation of spreading depression among dendrites and somata of the same cell population. 
  • Prophylaxis for second eye involvement in leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite. 
  • Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. 
  • Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. 
  • Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. 
  • Response to Gorelick. 
  • Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Safety and efficacy of brimonidine in children with glaucoma. 
  • Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. 
  • Successful management of orbital cellulitis and temporary visual loss after blepharoplasty. 
  • Suppression of presynaptic calcium currents by hypoxia in hippocampal tissue slices. 
  • Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. 
  • Synaptic basis for developmental plasticity in a birdsong nucleus. 
  • Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors. 
  • The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways. 
  • The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. 
  • The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor. 
  • Tonopen measurement of intraocular pressure in mice. 
  • Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. 
  • Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. 
  • Two-photon absorption properties of proquinoidal D-A-D and A-D-A quadrupolar chromophores. 
  • Varenicline effects on craving, cue reactivity, and smoking reward. 
  • Varenicline-induced drug eruption with resulting palmar/plantar hyperhidrosis and dysesthesia. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.