Radiation Tolerance

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  Subject Areas on Research

  • A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities. 
  • A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation. 
  • A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. 
  • A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint. 
  • A potential solution for eliminating hypoxia as a cause for radioresistance. 
  • ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer. 
  • ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. 
  • Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. 
  • Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. 
  • Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. 
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. 
  • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 
  • All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. 
  • Analysis of prognostic variables which influence early and long-term response of pet animal tumors to radiation alone and radiation plus heat. 
  • Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Axin gene methylation status correlates with radiosensitivity of lung cancer cells. 
  • Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Common responses of tumors and wounds to hypoxia. 
  • Computed tomography and radiation risks: what pediatric health care providers should know. 
  • Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. 
  • Demographic analysis and modeling of human populations exposed to ionizing radiation. 
  • Effect of temperature on blood flow and hypoxic fraction in a murine fibrosarcoma. 
  • Elevated Risk of Radiation Therapy-Associated Second Malignant Neoplasms in Young African-American Women Survivors of Stage I-IIIA Breast Cancer. 
  • Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. 
  • FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Functional assay to guide precision radiotherapy by assessing individual patient radiosensitivity. 
  • Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer. 
  • Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis. 
  • Gamma-radiation sensitivity and risk of glioma. 
  • Gamma-ray mutagen sensitivity and survival in patients with glioma. 
  • Gemcitabine-induced radiation recall myositis. 
  • Gender difference in smoking effect on chromosome sensitivity to gamma radiation in a healthy population. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. 
  • Genetic alterations in prostate adenocarcinoma. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. 
  • HIF-1 and tumour radiosensitivity. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability? 
  • Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? 
  • Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. 
  • Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials. 
  • In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). 
  • Intraoperative radiation therapy. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Involvement of two putative alternative sigma factors in stress response of the radioresistant bacterium Deinococcus radiodurans. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Irradiation and immunotherapy: From concept to the clinic. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. 
  • Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models. 
  • Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. 
  • Modeling hematopoietic system response caused by chronic exposure to ionizing radiation. 
  • Mutagen sensitivity and risk of gliomas: a case-control analysis. 
  • N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines. 
  • Neutrophils promote tumor resistance to radiation therapy. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era. 
  • Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. 
  • Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma? 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radiation dose-volume effects in the brain. 
  • Radiation dose-volume effects in the spinal cord. 
  • Radiation dose-volume effects in the stomach and small bowel. 
  • Radiation dose-volume effects of optic nerves and chiasm. 
  • Radiation effects in fluoroscopically guided cardiac interventions--keeping them under control. 
  • Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. 
  • Radiation therapy of sarcomas of the soft tissues. 
  • Radiation-associated kidney injury. 
  • Radiation-associated liver injury. 
  • Radiation-induced hypoxia may perpetuate late normal tissue injury. 
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity. 
  • Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. 
  • Reducing biochemical recurrence rates in EBRT-treated prostate cancer patients: the influence of dose and dose per fraction. 
  • Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells. 
  • Salvage Focal Cryotherapy Offers Similar Short-term Oncologic Control and Improved Urinary Function Compared With Salvage Whole Gland Cryotherapy for Radiation-resistant or Recurrent Prostate Cancer. 
  • Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice. 
  • Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways. 
  • Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. 
  • Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer. 
  • Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cells. 
  • Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling. 
  • The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. 
  • The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. 
  • The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice. 
  • Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. 
  • Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. 
  • Visible retinal lesions from ultrashort laser pulses in the primate eye. 
  • X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells. 
  • eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. 
  • rHuEPO and improved treatment outcomes: potential modes of action. 
  • βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering