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Subject Areas on Research
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A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk.
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A genetically tractable model of human glioma formation.
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A model for RAS mutation patterns in cancers: finding the sweet spot.
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A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.
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A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells.
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A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.
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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
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Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
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An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.
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Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms.
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Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
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Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
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Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages.
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Clinical correlates of NRAS and BRAF mutations in primary human melanoma.
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Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
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Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
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Creation of human tumour cells with defined genetic elements.
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Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.
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Cytogenetic and molecular correlates between rodent and human renal cell carcinoma.
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DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
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Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
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Detecting colorectal cancer in stool with the use of multiple genetic targets.
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Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization.
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Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer.
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Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
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Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
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Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis.
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Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
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Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients.
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Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
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ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.
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Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial.
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Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
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Effects of mutant Ran/TC4 proteins on cell cycle progression.
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Etiology of the mutational spectrum of ras genes in human carcinomas.
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Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib.
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Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma.
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G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
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Gene expression phenotypic models that predict the activity of oncogenic pathways.
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Genetic analysis of second primary lung cancers in patients surviving small cell lung cancer.
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Genetic changes in contralateral bronchioloalveolar carcinomas of the lung.
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Genetic modeling of human rhabdomyosarcoma.
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Ha-ras polymorphisms in epithelial ovarian cancer.
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Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
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High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
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Human ovarian cancer of the surface epithelium.
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Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.
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Imaging primary lung cancers in mice to study radiation biology.
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Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome.
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Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
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Infrequent RAS oncogene mutations in human prostate cancer.
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K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
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K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
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KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803.
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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
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Loss of heterozygosity for genes on 11p and the clinical course of patients with lung carcinoma.
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Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma.
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Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
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Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression.
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Molecular approaches for colorectal cancer screening.
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Molecular characterization of adenocarcinoma of the cervix.
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Molecular diagnosis of pancreatic and biliary cancer: ready for broad implementation?
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Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications.
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Mouse models of human non-small-cell lung cancer: raising the bar.
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Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.
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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.
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Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells.
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Mutations of the Ki-ras oncogene in endometrial carcinoma.
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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
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Needle-in-a-haystack detection and identification of base substitution mutations in human tissues.
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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.
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Oncogenic base substitution mutations in circulating leukocytes of normal individuals.
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Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
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Overview of genetic and molecular events in the pathogenesis of lung cancer.
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Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells.
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Personalized treatment of lung cancer.
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Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
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Preclinical efficacy of MEK inhibition in Nras-mutant AML.
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Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
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Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases.
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RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers.
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Rare codons regulate KRas oncogenesis.
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Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.
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Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
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Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells.
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Statistical analysis of skin tumor data from Tg.AC mouse bioassays.
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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
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TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract.
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The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.
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The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer.
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The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
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The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
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Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
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Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia.
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Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer.
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Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.
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Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.
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Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth.
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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
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p21ras is modified by a farnesyl isoprenoid.
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p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
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rac, a novel ras-related family of proteins that are botulinum toxin substrates.
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ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish.
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Keywords of People