Rats, Inbred ACI

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  Subject Areas on Research

  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. 
  • Age-related alterations in vitamin A metabolism in the rat retina. 
  • Allogeneic small bowel transplantation with cyclosporine and donor whole-body irradiation. 
  • Alterations in renal interleukin-1 production during kidney transplant rejection in the rat. The effects of high-dose methylprednisolone. 
  • Antisense oligodeoxynucleotides prevent acute cardiac allograft rejection via a novel, nontoxic, highly efficient transfection method. 
  • Associations between rat renal allograft function, inflammation, and host immunity. 
  • Characteristics of alloreactive rat T cell lines established from low and high rejecting orthotopic liver transplants. 
  • Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. 
  • Creation and properties of histocompatibility antigen-cell conjugates. I. Preparation and immunological properties of rat histocompatibility antigens. 
  • Creation and properties of histocompatibility antigen-cell conjugates. II. Antibody tolerance after treatment with donor histocompatibility antigen chemically coupled to recipient spleen cells. 
  • Distribution and mechanism of uptake of 111InCl3 in a tumor model for lymph node metastases. 
  • Effect of dietary fish oil supplementation on eicosanoid production by rat renal allografts. 
  • Effects of donor splenocytes treated with mitomycin C on rat hepatic, cardiac, and intestinal allografts. 
  • Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection. 
  • Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity. 
  • Graft-versus-leukemia in the rat--the antileukemic efficacy of syngeneic and allogeneic graft-versus-host disease. 
  • Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. 
  • Humoral rejection of rat hepatic transplants by passive transfer of serum. 
  • Hyperacute rejection of liver transplants in rats. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model. 
  • In vivo and in vitro effects of acute graft-versus-host serum in the rat. 
  • Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. 
  • Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance. 
  • Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. 
  • Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo. 
  • Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model. 
  • Prevention of ischemically induced neointimal hyperplasia using ex vivo antisense oligodeoxynucleotides. 
  • Rapid translocation of bacteria in small bowel transplantation. 
  • Role of platelet activating factor in kidney transplant rejection in the rat. 
  • Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts. 
  • Suppression of hepatic allograft rejection in the rat by mitomycin C-treated donor splenocytes: analysis of the immune status. 
  • The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. 
  • The azaspirane SKF 105685 ameliorates renal allograft rejection in rats. 
  • The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection. 
  • The effect of pretreatment with class I major histocompatibility complex (MHC) antigens on hepatic or cardiac allograft survival in the rat. 
  • The influence of RS-61443 on antibody-mediated rejection. 
  • The role of RT1.a major histocompatibility antigens in prolonging the survival of hepatic allografts in the rat. 
  • The role of class I antigens in hyperacute rejection of hepatic allografts in rats. 
  • Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. 
  • Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats. 
  • Total lymphoid irradiation and cyclosporine prolongs cardiac allograft survival in the sensitized rat model. 
  • Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 
  • Use of donor serum to prevent passive transfer of hyperacute rejection. 
  • Variable allograft responses to pretreatment with donor splenocytes treated with mitomycin C in the rat.