Rats, Inbred F344

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  Subject Areas on Research

  • 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. 
  • 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis. 
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. 
  • 6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors. 
  • A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma. 
  • A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. 
  • A controlled study of efficacy of interstitial or external irradiation in a virus-induced brain-tumor model in rats. 
  • A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. 
  • A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. 
  • A model of sequential heart and composite tissue allotransplant in rats. 
  • A new in vivo method for quantitative analysis of stroke lesions using diffusion-weighted magnetic resonance microscopy. 
  • A novel rodent mammary window of orthotopic breast cancer for intravital microscopy. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A rat liver 57-kDa protein is identified to share antigenic determinants with statin, a marker for nonproliferating cells. 
  • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. 
  • Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation. 
  • Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide. 
  • Adenosine nucleotides in bile. 
  • Age and dose sensitivities in the 2-butoxyethanol F344 rat model of hemolytic anemia and disseminated thrombosis. 
  • Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors. 
  • Age-associated differences in beta adrenergic-stimulated lipolysis in adipocytes from Sprague-Dawley and Fischer 344 rats. 
  • Age-related alterations in potentiation in the CA1 region in F344 rats. 
  • Age-related changes in brain catecholamine responses to a single footshock. 
  • Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. 
  • Age-related metabolic fatigue during low glucose conditions in rat hippocampus. 
  • Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation. 
  • Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. 
  • Airway branching patterns influence asbestos fiber location and the extent of tissue injury in the pulmonary parenchyma. 
  • Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. 
  • Altered responsiveness to alcohol after exposure to organic lead. 
  • Alveolar epithelial cell injuries by subchronic exposure to low concentrations of ozone correlate with cumulative exposure. 
  • Alveolar type II cell responses to chronic inhalation of chrysotile asbestos in rats. 
  • Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. 
  • An age-related difference in hyperoxia lethality: role of lung antioxidant defense mechanisms. 
  • Analysis of oxygen transport to tumor tissue by microvascular networks. 
  • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. 
  • Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Antioxidant defense mechanisms in cultured pleural mesothelial cells. 
  • Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism. 
  • Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile. 
  • Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content. 
  • Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. 
  • Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration. 
  • Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. 
  • Baclofen disrupts passive avoidance retention in rats. 
  • Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats. 
  • Bayesian models for multivariate current status data with informative censoring. 
  • Behavioral thermoregulation in the rat following the oral administration of ethanol. 
  • Blood-brain barrier disruption in immature Fischer 344 rats. 
  • Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. 
  • Brain tumors in man and animals: report of a workshop. 
  • Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds. 
  • Captopril reduces graft coronary artery disease in a rat heterotopic transplant model. 
  • Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels. 
  • Carcinogen-induced unscheduled DNA synthesis in xenotransplanted human tracheobronchial epithelium: comparison with rat tracheal epithelium. 
  • Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. 
  • Cardiac morphology and function in senescent rats: gender-related differences. 
  • Carotid artery injections in 40- to 99-g Fischer rats: technical note and evaluation of blood flow by various injection techniques. 
  • Cellular immunity in rats with primary brain tumors: inhibition of macrophage migration by soluble extracts of avian sarcoma virus-induced tumors. 
  • Central neurotoxicity after exposure to organic lead: susceptibility to seizures. 
  • Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells. 
  • Characterization of the innate immune response to chronic aspiration in a novel rodent model. 
  • Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. 
  • Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays. 
  • Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation. 
  • Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. 
  • Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. 
  • Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by [3H]-acetylcholine. 
  • Comparison of fluctuations of oxygen tension in FSA, 9L, and R3230AC tumors in rats. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. 
  • Comparison of various methods for delivering radiolabeled monoclonal antibody to normal rat brain. 
  • Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. 
  • Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. 
  • Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. 
  • Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. 
  • Cyclocreatine in cancer chemotherapy. 
  • Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats. 
  • Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness 
  • Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. 
  • Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns. 
  • Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: intracellular staining in vivo and in vitro. 
  • Denervation-induced dendritic alterations in CA1 pyramidal cells following kainic acid hippocampal lesions in rats. 
  • Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes. 
  • Detection of bromobenzene-induced hepatocellular necrosis using magnetic resonance microscopy. 
  • Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. 
  • Determination of local oxygen consumption rates in tumors. 
  • Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus. 
  • Developmental changes in carbachol-stimulated inositolphosphate release in pigmented rat retina. 
  • Diagnostic exercise: eye lesions in rats. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Dietary vitamins A and E influence retinyl ester composition and content of the retinal pigment epithelium. 
  • Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. 
  • Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation. 
  • Differential effects of parenteral nutrition on tumor growth and erythrocyte polyamine levels in the rat. 
  • Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. 
  • Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth. 
  • Diltiazem preserves direct vasodilator response but fails to suppress intimal proliferation in rat allograft coronary artery disease. 
  • Diminished leukocyte-endothelium interaction in tumor microvessels. 
  • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. 
  • Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: I. Experimental characterizations. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations. 
  • Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. 
  • Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration. 
  • Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation. 
  • Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. 
  • Early wound healing exhibits cytokine surge without evidence of hypoxia. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition. 
  • Effect of erionite on the pleural mesothelium of the Fischer 344 rat. 
  • Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations. 
  • Effect of glutamine-supplemented intravenous nutrition on survival after Escherichia coli-induced peritonitis. 
  • Effect of glutamine-supplemented total parenteral nutrition on recovery of the small intestine after starvation atrophy. 
  • Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma. 
  • Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats. 
  • Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation. 
  • Effect of methylprednisolone on radiotherapy of F344 rats with avian sarcoma virus induced gliomas. 
  • Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. 
  • Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. 
  • Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature. 
  • Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents. 
  • Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma. 
  • Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. 
  • Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. 
  • Effects of enteral feeding products on survival from Escherichia coli peritonitis. 
  • Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats. 
  • Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats. 
  • Effects of perinatal alcohol exposure and dietary calcium supplements on skeletal and dental growth in rats. 
  • Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. 
  • Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. 
  • Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature. 
  • Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats. 
  • Electrical stimulation of gut motility guided by an in silico model. 
  • Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study. 
  • Enhanced optical imaging of rat gliomas and tumor margins. 
  • Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. 
  • Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. 
  • Evans blue nanocarriers visually demarcate margins of invasive gliomas. 
  • Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase. 
  • Experimental gliomas: an autoradiographic study of the endothelial component. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification. 
  • Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture. 
  • Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. 
  • Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines. 
  • Expression of statin, a non-proliferation-dependent nuclear protein, in the postnatal rat brain: evidence for substantial retention of neuroglial proliferative capacity with aging. 
  • Expression of terminin, a senescence-related cytoplasmic protein, in the aging rat brain. 
  • Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain. 
  • Fetal hippocampal cells grafted to kainate-lesioned CA3 region of adult hippocampus suppress aberrant supragranular sprouting of host mossy fibers. 
  • Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. 
  • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. 
  • Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats. 
  • Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. 
  • Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats. 
  • Functional significance of erythropoietin receptor expression in breast cancer. 
  • GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine. 
  • Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats. 
  • General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. 
  • Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma. 
  • Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. 
  • Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. 
  • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. 
  • Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. 
  • Hepatocyte receptors for antithrombin III-proteinase complexes. 
  • Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III. 
  • Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor. 
  • Heterogeneity in tumor microvascular response to radiation. 
  • Hexabromonaphthalene contaminants of polybrominated biphenyls: chemical composition and disposition in the rat. 
  • High affinity binding of [3H]epibatidine to rat brain membranes. 
  • Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. 
  • Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. 
  • Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide. 
  • Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. 
  • Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model. 
  • Improving temporal resolution of pulmonary perfusion imaging in rats using the partially separable functions model. 
  • In situ nuclear morphology measurements using light scattering as biomarkers of neoplastic change in animal models of carcinogenesis. 
  • In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts. 
  • In utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice. 
  • In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS. 
  • In vivo MRI using real-time production of hyperpolarized 129Xe. 
  • In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine. 
  • In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. 
  • Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats. 
  • Increased hypothalamic [3H]flunitrazepam binding in hypothalamic-pituitary-adrenal axis hyporesponsive Lewis rats. 
  • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. 
  • Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. 
  • Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke. 
  • Induction of rat kidney ornithine decarboxylase by nicotinamide without a concomitant increase in DNA synthesis. 
  • Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 rats. 
  • Influence of total parenteral nutrition on tumor growth and polyamine biosynthesis of fibrosarcoma-bearing rats after induced cachexia. 
  • Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. 
  • Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. 
  • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. 
  • Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism. 
  • Interstitial hydraulic conductivity in a fibrosarcoma. 
  • Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). 
  • Intracerebral transplantation of a human glioma line in immunosuppressed rats. 
  • Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression. 
  • Isolation and characterization of microvessels from normal brain and brain tumors. 
  • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. 
  • Laryngeal transplantation in the setting of cancer: a rat model. 
  • Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion. 
  • Localization of S1 and elongation factor-1 alpha mRNA in rat brain and liver by non-radioactive in situ hybridization. 
  • Long-circulating liposomal contrast agents for magnetic resonance imaging. 
  • Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. 
  • Long-term safety of combined intracerebral delivery of free gadolinium and targeted chemotherapeutic agent PRX321. 
  • Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. 
  • Lung injury after ozone exposure is iron dependent. 
  • Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution. 
  • MK-801 impedes the acquisition of a spatial memory task in rats. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study. 
  • Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. 
  • Magnetic resonance microscopy and histopathology: comparative approach of bromobenzene-induced hepatotoxicity in the rat. 
  • Magnetic resonance microscopy of chemically-induced liver foci. 
  • Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. 
  • Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. 
  • Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection. 
  • Medial smooth muscle cell loss in arterial allografts occurs by cytolytic cell induced apoptosis. 
  • Mesothelial cell proliferation induced by intrapleural instillation of man-made fibers in rats and hamsters. 
  • Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors. 
  • Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. 
  • Microvascular studies on the origins of perfusion-limited hypoxia. 
  • Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo. 
  • Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. 
  • Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. 
  • Morphometric characteristics of cells in the alveolar region of mammalian lungs. 
  • N-methyl-D-aspartate receptor binding in brains of rats at different ages. 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • NGF is essential for hippocampal plasticity and learning. 
  • NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system. 
  • Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening. 
  • Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. 
  • Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. 
  • Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. 
  • Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. 
  • Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels. 
  • Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. 
  • Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. 
  • New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. 
  • New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. 
  • Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. 
  • Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Non-phosphorylated neurofilament protein immunoreactivity in adult and developing rat hippocampus: specificity and application in grafting studies. 
  • Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids. 
  • Opioid-induced epileptiform bursting in hippocampal slices: higher susceptibility in ventral than dorsal hippocampus. 
  • Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats. 
  • Optical mapping of translucence changes in rat hippocampal slices during hypoxia. 
  • Osteopontin expression in particle-induced lung disease. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • Oxygen distributions within R3230Ac tumors growing in dorsal flap window chambers in rats. 
  • Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide. 
  • Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. 
  • Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies. 
  • Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells. 
  • Performance of a high-temperature superconducting probe for in vivo microscopy at 2.0 T. 
  • Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. 
  • Permeability of different experimental brain tumor models to horseradish peroxidase. 
  • Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography. 
  • Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. 
  • Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. 
  • Pleural dosimetry and pathobiological responses in rats and hamsters exposed subchronically to MMVF 10a fiberglass. 
  • Pleural lesions in Syrian golden hamsters and Fischer-344 rats following intrapleural instillation of man-made ceramic or glass fibers. 
  • Pleural macrophage recruitment and activation in asbestos-induced pleural injury. 
  • Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing. 
  • Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts. 
  • Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze. 
  • Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. 
  • Prevention of glioma induction in rats by simultaneous intracerebral inoculation of avian sarcoma virus plus bacillus Calmette-Guerin cell-wall preparation. 
  • Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water. 
  • Primary optic nerve meningiomas in F344 rats. 
  • Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study. 
  • Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus. 
  • Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry. 
  • Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). 
  • Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats. 
  • Pulmonary and pleural leukocytes from F344 rats produce elevated levels of fibronectin following inhalation of refractory ceramic fibers. 
  • Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. I. Quantitation of lung and pleural fiber burdens. 
  • Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. II. Pathobiologic responses. 
  • Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity. 
  • Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe. 
  • Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI. 
  • Purification and biochemical characterization of statin, a nonproliferation specific protein from rat liver. 
  • Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. 
  • Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. 
  • Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats. 
  • Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography. 
  • Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay. 
  • Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus. 
  • Radiation-induced hypoxia may perpetuate late normal tissue injury. 
  • Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose. 
  • Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. 
  • Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents. 
  • Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors. 
  • Rational identification of a novel peptide for targeting nanocarriers to 9L glioma. 
  • Reactive astrocytes express the embryonic intermediate neurofilament nestin. 
  • Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. 
  • Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion. 
  • Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression. 
  • Redox properties of cytochrome oxidase and vascular reactivity of astrocytomas and neuroblastomas in vivo. 
  • Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. 
  • Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. 
  • Regional blood-to-tissue transport in avian sarcoma virus (ASV)-induced brain tumors. 
  • Regional measurements of blood flow in experimental RG-2 rat gliomas. 
  • Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. 
  • Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain. 
  • Registered (1)H and (3)He magnetic resonance microscopy of the lung. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Relaxation measurements at 300 MHz using MR microscopy. 
  • Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. 
  • Renal tubular carcinoma; animal model: chemically induced renal tubular carcinoma in rats. 
  • Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). 
  • Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust. 
  • Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. 
  • Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. 
  • Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. 
  • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. 
  • SU5416 delays wound healing through inhibition of TGF-beta 1 activation. 
  • Safety evaluation of carbon tetrafluoride as an inert hyperbaric breathing gas in Sprague-Dawley rats. 
  • Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore. 
  • Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. 
  • Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. 
  • Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. 
  • Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. 
  • Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires. 
  • Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells. 
  • Spatial distribution of proliferating cells in avian sarcoma virus-induced gliomas. 
  • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. 
  • Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats. 
  • Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy. 
  • Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood. 
  • Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure. 
  • Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. 
  • Studies on bromobenzene-induced hepatotoxicity using in vivo MR microscopy with surgically implanted RF coils. 
  • Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. 
  • Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages. 
  • Surface morphology of normal and neoplastic rat cells. 
  • Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. 
  • Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome. 
  • Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models. 
  • Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats. 
  • Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. 
  • The effect of choline supplementation on hepatic steatosis in the parenterally fed rat. 
  • The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. 
  • The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. 
  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. 
  • The effect of levofloxacin on the lung microbiota of laboratory rats. 
  • The effect of nicotinamide & hyperoxic gases on blood glucose. 
  • The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. 
  • The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization. 
  • The effects of hyperoxic and hypercarbic gases on tumour blood flow. 
  • The fine structure of intracranial neoplasms induced by the inoculation of avian sarcoma virus in neonatal and adult rats. 
  • The induction of intractranial neoplasms by the inoculation of avian sarcoma virus in perinatal and adult rats. 
  • The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. 
  • The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. 
  • The pervasive presence of fluctuating oxygenation in tumors. 
  • The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. 
  • The role of soluble and insoluble gastric fluid components in the pathogenesis of obliterative bronchiolitis in rat lung allografts. 
  • The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks. 
  • Thin-film enhanced nerve guidance channels for peripheral nerve repair. 
  • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. 
  • Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates. 
  • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. 
  • Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. 
  • Tomographic digital subtraction angiography for lung perfusion estimation in rodents. 
  • Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain. 
  • Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Transplantation of multipotent progenitors from the adult olfactory epithelium. 
  • Treatment of autochthonous rat brain tumors with steroid plus heparin: a brief report. 
  • Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. 
  • Tumor resistance in rats immunized to fetal tissues. 
  • Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing. 
  • Turnover rates of amino acid neurotransmitters in regions of rat cerebellum. 
  • Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations. 
  • Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. 
  • Use of lung toxicity and lung particle clearance to estimate the maximum tolerated dose (MTD) for a fiber glass chronic inhalation study in the rat. 
  • Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers. 
  • Variability in blood flow and pO2 in tumors in response to carbogen breathing. 
  • Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. 
  • Ventilation/perfusion imaging in a rat model of airway obstruction. 
  • Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid. 
  • [Using Hsp70 promoter to regulate target gene expression in tumor]. 
  • alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. 
• 

  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering