Rats, Inbred Lew

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  Subject Areas on Research

  • A new approach for assessing early osteoarthritis in the rat. 
  • A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model. 
  • Adenovirus-mediated gene transfer into rat cardiac allografts. Comparison of direct injection and perfusion. 
  • Adult adipose-derived stem cell attachment to biomaterials. 
  • Allogeneic small bowel transplantation with cyclosporine and donor whole-body irradiation. 
  • Angiogenesis in tissue-engineered small intestine. 
  • Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. 
  • Antisense to transforming growth factor-beta(1) facilitates the apoptosis of macrophages in rat vein grafts. 
  • Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. 
  • Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats. 
  • Bilateral native nephrectomy improves renal isograft function in rats. 
  • Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants. 
  • Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum. 
  • Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. 
  • Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation. 
  • CD62-PSGL-1 interactions regulate cytokine chemokine and apoptotic networks in cardiac allograft recipients. 
  • Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. 
  • Characteristics of alloreactive rat T cell lines established from low and high rejecting orthotopic liver transplants. 
  • Characteristics of corneal xenograft rejection in a discordant species combination. 
  • Characterization of a composite injury model of severe lower limb bone and nerve trauma. 
  • Characterization of ventral incisional hernia and repair using shear wave elastography. 
  • Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. 
  • Combined total lymphoid irradiation and cyclosporine promote xenograft survival. 
  • Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. 
  • Corneal neovascularization induced by xenografts or chemical cautery. Inhibition by cyclosporin A. 
  • Creation and properties of histocompatibility antigen-cell conjugates. I. Preparation and immunological properties of rat histocompatibility antigens. 
  • Creation and properties of histocompatibility antigen-cell conjugates. II. Antibody tolerance after treatment with donor histocompatibility antigen chemically coupled to recipient spleen cells. 
  • Cyclosporine and experimental skin allografts. II. Indefinite survival and development of specific immunologic unresponsiveness. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice™ mesh in a rodent ventral hernia model. 
  • Determination of optimal duration of mechanical unloading for failing hearts to achieve bridge to recovery in a rat heterotopic heart transplantation model. 
  • Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms. 
  • Echocardiographic assessment of cardiac morphology and function in mutant dwarf rats. 
  • Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. 
  • Effect of modulating macrophage phenotype on peripheral nerve repair. 
  • Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection. 
  • Effects of donor splenocytes treated with mitomycin C on rat hepatic, cardiac, and intestinal allografts. 
  • Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors. 
  • Evaluation of selective liver denervation methods. 
  • Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow. 
  • Experimental allergic encephalomyelitis in Lewis rats bearing avian sarcoma virus-induced brain tumors. 
  • Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. 
  • Facilitatory effects of 4-aminopyridine on normal neuromuscular transmission. 
  • Functional activity of anti-C6 antibodies elicited in C6-deficient rats reconstituted by liver allografts. Ability to inhibit hyperacute rejection of discordant cardiac xenografts. 
  • Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface. 
  • Further electrophysiological studies of neuromuscular transmission in an animal model of myasthenia gravis. 
  • Gene therapy in transplantation. 
  • Gene transfer and expression in rat cardiac transplants. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus. 
  • Graft-versus-leukemia in the rat--the antileukemic efficacy of syngeneic and allogeneic graft-versus-host disease. 
  • Hepatic allograft-derived Kupffer cells regulate T cell response in rats. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. 
  • High-resolution imaging of progressive articular cartilage degeneration. 
  • Histopathologic features of rejecting orthotopic corneal xenografts. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. 
  • Humoral rejection of rat hepatic transplants by passive transfer of serum. 
  • Hyperacute rejection of liver transplants in rats. 
  • IFATS collection: Adipose-derived stromal cells improve the foreign body response. 
  • Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model. 
  • Importance of an intact growth hormone/insulin-like growth factor 1 axis for normal post-infarction healing: studies in dwarf rats. 
  • In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. 
  • In vivo and in vitro effects of acute graft-versus-host serum in the rat. 
  • In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. 
  • Increased IL-4 production and attenuated proliferative and pro-inflammatory responses of splenocytes from wild-caught rats (Rattus norvegicus). 
  • Induction of anti-myelin antibodies in EAE and their possible role in demyelination. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. 
  • Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance. 
  • Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. 
  • Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes. 
  • Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. 
  • Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes. 
  • Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation. 
  • Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression. 
  • Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. 
  • Isoflurane alters the kinetics of oral cyclosporine. 
  • Killing of Cryptococcus neoformans by rat alveolar macrophages. 
  • Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. 
  • LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. 
  • Lambert-Eaton myasthenic syndrome: the lack of short-term in vitro effects of serum factors on neuromuscular transmission. 
  • Localization of mesenchymal stem cells grafted with a hyaluronan-based scaffold in the infarcted heart. 
  • Lymphangiogenesis in tissue-engineered small intestine. 
  • Macrophage migration into hepatic xenografts in the hamster-to-rat combination. 
  • Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel. 
  • Medial smooth muscle cell loss in arterial allografts occurs by cytolytic cell induced apoptosis. 
  • Mitochondrial DNA damage as a peripheral biomarker for mitochondrial toxin exposure in rats. 
  • Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. 
  • Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo. 
  • Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium. 
  • Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. 
  • Molecular sequelae of topographically guided peripheral nerve repair. 
  • Near-infrared lymphography as a minimally invasive modality for imaging lymphatic reconstitution in a rat orthotopic hind limb transplantation model. 
  • Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats. 
  • Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity. 
  • Paramagnetic polymerized liposomes as new recirculating MR contrast agents. 
  • Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. 
  • Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum. 
  • Phagocytosis of Cryptococcus neoformans by rat alveolar macrophages. 
  • Pharmacological stimulation of the cholinergic antiinflammatory pathway. 
  • Phenotype and patterns of inflammatory cell infiltration associated with rejection or acceptance of rat liver allografts. 
  • Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model. 
  • Platelet rich plasma enhances tissue incorporation of biologic mesh. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction. 
  • Prolonged survival of hepatic xenografts in the hamster to rat combination: efficacy of cyclosporine in combination with splenectomy. 
  • Protective effect of an inhibitor of interleukin-8 (meraxin) from ischemia and reperfusion injury in a rat model of kidney transplantation. 
  • Rapamycin suppression of host-versus-graft and graft-versus-host disease in MHC-mismatched rats. 
  • Rapid translocation of bacteria in small bowel transplantation. 
  • Rat strain differences in complement activity correlate with hyperacute rejection of guinea pig cardiac xenografts. 
  • Recipient Kupffer cell influx into xenografted liver. 
  • Recruitment of host progenitor cells in rat liver transplants. 
  • Regenerative scaffold electrodes for peripheral nerve interfacing. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Reinnervation of adult rat gastrocnemius muscle by embryonic motoneurons transplanted into the axotomized tibial nerve. 
  • Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. 
  • SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. 
  • Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy. 
  • Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts. 
  • Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. 
  • Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Suppression of hepatic allograft rejection in the rat by mitomycin C-treated donor splenocytes: analysis of the immune status. 
  • Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats. 
  • Synchronous intestinal transplantation inhibits post resection adaptation. 
  • The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. 
  • The azaspirane SKF 105685 ameliorates renal allograft rejection in rats. 
  • The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival. 
  • The effect of TLI and cyclosporine on xenograft survival. 
  • The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection. 
  • The effect of pretreatment with class I major histocompatibility complex (MHC) antigens on hepatic or cardiac allograft survival in the rat. 
  • The effect of soluble complement receptor type 1 on hyperacute allograft rejection. 
  • The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. 
  • The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. 
  • The influence of RS-61443 on antibody-mediated rejection. 
  • The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model. 
  • The microsurgical triple clamp: a technique for microvascular grafting of short interposition grafts. 
  • The mutual benefit role of liver and pancreas in combined transplantation. 
  • The role of RT1.a major histocompatibility antigens in prolonging the survival of hepatic allografts in the rat. 
  • The role of class I antigens in hyperacute rejection of hepatic allografts in rats. 
  • The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury. 
  • Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. 
  • Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. 
  • Tissue-engineered small intestine: ontogeny of the immune system. 
  • Total lymphoid irradiation and cyclosporine prolongs cardiac allograft survival in the sensitized rat model. 
  • Transplantation of rat insulinoma allografts with cyclosporin A. 
  • Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation. 
  • Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 
  • Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP). 
  • Use of donor serum to prevent passive transfer of hyperacute rejection. 
  • Use of tissue blood flow and high energy phosphate content to predict small bowel graft survival. 
  • Variable allograft responses to pretreatment with donor splenocytes treated with mitomycin C in the rat. 
  • Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine. 
  • [Lymphocyte subpopulations in spleen and blood after early wound debridement and acute/chronic treatment with hyperbaric oxygen].