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Subject Areas on Research
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(3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors.
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125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.
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A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy.
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A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor.
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A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.
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A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.
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A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
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Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.
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Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release.
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Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines.
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Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization.
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Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding.
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Adrenergic receptors in the heart.
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Adrenergic receptors.
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Adrenergic receptors.
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Adrenergic receptors. Models for regulation of signal transduction processes.
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Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.
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Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications.
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Adrenergic receptors: molecular mechanisms of clinically relevant regulation.
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Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
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Adrenoceptors, uncoupling proteins, and energy expenditure.
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Affinity chromatography of adrenergic receptors and binding proteins.
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Affinity chromatography of human platelet alpha 2-adrenergic receptors.
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Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations.
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Affinity chromatography of the beta-adrenergic receptor.
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Age-associated loss of beta adrenergic receptors from human lymphocytes in vivo [proceedings].
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Agonist interactions with alpha-adrenergic receptors.
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Agonist versus antagonist binding to alpha-adrenergic receptors.
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Agonist-induced increase in apparent beta-adrenergic receptor size.
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Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.
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Agonist-promoted high affinity state of the beta-adrenergic receptor in human neutrophils: modulation by corticosteroids.
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Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors.
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Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.
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Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets.
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Alpha 2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: direct demonstration by radioligand binding.
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Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens.
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Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding.
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Alpha-adrenergic receptor subtypes.
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Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding.
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Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands.
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Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.
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Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands.
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An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine.
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Anomalous equilibrium binding properties of high-affinity racemic radioligands.
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Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands.
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Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.
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Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans.
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Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.
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Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation.
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Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia.
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Beta adrenergic receptors in lymphocyte subpopulations.
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Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism.
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Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes.
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Beta-adrenergic receptor binding: synaptic localization in rat brain.
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Beta-adrenergic receptors: evidence for negative cooperativity.
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Beta-adrenergic receptors: recognition and regulation.
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Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants.
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Binding of catecholamines to receptors in cultured myocardial cells.
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Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies.
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Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte.
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Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
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Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.
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Catecholamine binding to the beta-adrenergic receptor.
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Catecholamine receptors: structure, function, and regulation.
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Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number.
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Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
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Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.
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Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.
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Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex.
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Chronic guanethidine treatment increases cardiac beta-adrenergic receptors.
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Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
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Clinical physiology of adrenergic receptor regulation.
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Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report.
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Comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic receptors.
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Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.
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Corticosteroid-induced differential regulation of beta-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes.
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Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels.
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Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.
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Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.
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Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands.
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Development of adrenergic receptor binding sites in brain regions of the neonatal rat: effects of prenatal or postnatal exposure to methylmercury.
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Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain.
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Development of the linkage of beta-adrenergic receptors to cardiac hypertrophy and heart rate control: neonatal sympathectomy with 6-hydroxydopamine.
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Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization.
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Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors.
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Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling.
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Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes.
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Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides.
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Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.
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Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle.
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Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications.
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Direct identification and characterisation of beta-adrenergic receptors in rat brain.
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Direct studies of beta-adrenergic receptors intact frog erythrocytes.
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Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.
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Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
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Editorial: Selectivity in beta-adrenergic responses: clinical implications.
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Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice.
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Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and on beta-adrenergic receptors.
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Elevated beta-adrenergic receptor number after chronic propranolol treatment.
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Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats.
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Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.
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Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity.
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Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors.
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Functional consequences of altering myocardial adrenergic receptor signaling.
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Functional integrity of desensitized beta-adrenergic receptors.
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Functional selectivity in adrenergic and angiotensin signaling systems.
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Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.
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Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity.
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Guanine nucleotides and alpha 1 adrenergic receptors in the heart.
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Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine.
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Hepatic fibrogenesis requires sympathetic neurotransmitters.
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Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors.
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Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.
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Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes.
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Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition.
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Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding.
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Hypothermia: role of alpha 1- and alpha 2-noradrenergic receptors in the hypothalamus of the cat.
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Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.
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Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in hog pial membranes.
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Identification and regulation of alpha- and beta-adrenergic receptors.
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Identification and regulation of beta-adrenergic receptors.
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Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists.
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Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding.
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Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding.
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Identification of beta adrenergic receptors in rat hypothalamus.
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Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.
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Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding.
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Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography.
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In situ hybridization of adrenergic receptor mRNA in brain.
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In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids.
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Inhibition of epinephrine-induced vasospasm with adrenoreceptor blockade in the rat cremaster muscle.
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Interaction of signals influencing renin release.
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Interactions of agonists with platelet alpha 2-adrenergic receptors.
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International Union of Pharmacology nomenclature of adrenoceptors.
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Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines.
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Isolated hormone receptors: physiologic and clinical implications.
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Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands.
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Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
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Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes.
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Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.
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Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody.
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Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors.
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Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.
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Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.
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Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase.
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Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.
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Modulation of hepatic adrenergic receptor ontogeny by thyroid hormone.
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Molecular and regulatory properties of adrenergic receptors.
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Molecular biology of adrenergic receptors in the rat and frog central nervous system.
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Molecular characterization of the beta-adrenergic receptor of frog erythrocytes.
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Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors.
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Molecular mechanisms of beta-adrenergic receptor desensitization.
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Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors.
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Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations.
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Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes.
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Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors.
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Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired formation of high-affinity agonist-receptor complexes.
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NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis.
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Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.
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Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation.
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Network integration of the adrenergic system in cardiac hypertrophy.
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Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase.
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Neurobiological mechanisms in generalized anxiety disorder.
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New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance.
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Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium.
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Ontogeny of rat hepatic adrenoceptors.
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Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid.
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Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells.
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Peripheral alpha-adrenergic receptor subtypes.
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Pharmacological characterizations of adrenergic receptors in human adipocytes.
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Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.
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Photoaffinity labeling of the beta-adrenergic receptor.
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Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity.
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Physical conditioning and membrane receptors for cardioregulatory hormones.
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Physiological receptors as physicochemical entities.
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Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase.
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Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment.
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Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.
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Postnatal nutritional status influences development of cardiac adrenergic receptor binding sites.
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Potent beta-adrenergic antagonist possessing chemically reactive group.
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Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets.
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Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges.
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Production of adrenergic receptors in yeast.
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Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.
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Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique.
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Race, common genetic variation, and therapeutic response disparities in heart failure.
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Radioligand binding studies of adrenergic receptors: new insights into molecular and physiological regulation.
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Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.
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Reduced beta-adrenergic receptor concentrations in ageing man.
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Regulation of G protein-coupled receptor signaling by scaffold proteins.
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Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines.
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Regulation of adenylate cyclase coupled beta-adrenergic receptors.
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Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro.
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Regulation of adrenergic receptor function by phosphorylation.
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Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.
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Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes.
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Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.
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Regulation of beta-adrenergic receptors by phospholipid methylation.
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Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone.
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Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids.
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Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.
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Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.
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Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes.
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Role of phosphorylation in desensitization of the beta-adrenoceptor.
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Role of receptor mechanisms in the adaptive response to habitual exercise.
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Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization.
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Selective alterations of regional beta-adrenergic receptor binding in the kindling model of epilepsy.
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Selectivity of dobutamine for adrenergic receptor subtypes: in vitro analysis by radioligand binding.
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Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography.
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Seven-transmembrane-spanning receptors and heart function.
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Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.
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Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.
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Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase.
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Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors.
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Structure and function of the adrenergic receptor family.
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Structure of the adrenergic and related receptors.
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Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.
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Subclassification of alpha-adrenergic receptors by direct binding studies.
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Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.
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Subtype specificity of alpha-adrenergic receptors in rat heart.
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Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe.
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Techniques for the study of the biochemical basis of drug action.
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Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors.
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The Gordon Wilson lecture. Adrenergic receptors: regulation at the biochemical, physiological and clinical levels.
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The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.
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The beta-adrenergic receptor and adenylate cyclase.
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The beta-adrenergic receptor.
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The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.
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The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.
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The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters.
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The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations.
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The identification of adrenergic receptors in human pial membranes.
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The impact of aging on adrenergic receptor function: clinical and biochemical aspects.
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The mammalian beta-adrenergic receptors.
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Thyroid hormone modulation of agonist--beta-adrenergic receptor interactions in the rat heart.
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Thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium.
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Thyroid hormone regulation of beta-adrenergic receptor number.
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Thyroxine and propylthiouracil effects on alpha- and beta-adrenergic receptor number, ATPase activities, and sialic acid content of rat cardiac membrane vesicles.
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Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts.
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Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases.
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Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions.
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Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes.
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Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.
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[3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes.
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[3H]WB4101--caution about its role as an alpha-adrenergic subtype selective radioligand.
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[3H]dihydroergocryptine binding in rat brain.
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alpha-Adrenergic receptors in human adipocyte membranes: direct determination by [3H]yohimbine binding.
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alpha-Adrenergic receptors in rat parotid cells. I. Correlation of [3H]dihydroergocryptine binding and catecholamine-stimulated potassium efflux.
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alpha-Adrenergic receptors in rat parotid cells. II. Desensitization of receptor binding sites and potassium release.
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beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.
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beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.
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beta-adrenergic receptors in brown adipose tissue: identification by (-)[3H]dihydroalprenolol binding.
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