Receptors, Androgen

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  Subject Areas on Research

  • A role for the androgen receptor in the treatment of male breast cancer. 
  • A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes. 
  • Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. 
  • Actions of steroids in mitochondria. 
  • Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. 
  • Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. 
  • Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta). 
  • Androgen receptor activation by G(s) signaling in prostate cancer cells. 
  • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. 
  • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. 
  • Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. 
  • Androgen receptor-cofactor interactions as targets for new drug discovery. 
  • Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer. 
  • CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. 
  • CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Characterization of androgen receptor in Sertoli cell-enriched testis. 
  • Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity. 
  • Clinical Utility of Circulating Tumor Cells in Advanced Prostate Cancer. 
  • Cloning of human androgen receptor complementary DNA and localization to the X chromosome. 
  • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. 
  • Controversies in the treatment of prostate cancer with maximal androgen deprivation. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. 
  • Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors. 
  • Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. 
  • Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. 
  • Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor. 
  • Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. 
  • Evaluation and treatment of male and female pattern hair loss. 
  • Evaluation of ligand-dependent changes in AR structure using peptide probes. 
  • Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer. 
  • Expression of androgen and estrogen related proteins in normal weight and obese prostate cancer patients. 
  • Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. 
  • Genetic alterations in prostate adenocarcinoma. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. 
  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. 
  • Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. 
  • Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. 
  • Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. 
  • Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. 
  • Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB. 
  • Molecular implications of the antiandrogen withdrawal syndrome. 
  • New treatment options in castration-resistant prostate cancer. 
  • Novel chemotherapies in development for management of castration-resistant prostate cancer. 
  • Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. 
  • Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. 
  • Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic Breast Cancer. 
  • Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. 
  • Properties of an intermediate-sized androgen receptor: association with RNA. 
  • Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men. 
  • Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. 
  • Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site. 
  • Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. 
  • Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP). 
  • Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials). 
  • The Molecular Taxonomy of Primary Prostate Cancer. 
  • The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The production of androgen binding protein by Sertoli Cells. 
  • The urology perspective on expanding androgen-targeted treatments for men with castration-resistant prostate cancer. 
  • Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. 
  • Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
  • Using circulating tumor cells to inform on prostate cancer biology and clinical utility. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute